Non-Skeletal Benefits of Vitamin D

Bhatt, Neeru; Ali, Amanat; Waly, Mostafa I.

doi:10.14206/canad.j.clin.nutr.2019.01.12

Cited by 6 publications

(7 citation statements)

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“…Vitamin D, a lipid-soluble vitamin, is well-known for regulating bone metabolism and calcium-phosphorus homeostasis [ 11 ]. However, it exerts a variety of non-skeletal benefits, mainly managing different chronic diseases as well [ 12 , 13 ]. Vitamin D deficiency is involved in abnormal glucose metabolism, altered insulin secretion and T2DM [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin D supplementation on type 2 diabetes biomarkers: an umbrella of interventional meta-analyses

Musazadeh

Kavyani

Mirhosseini

et al. 2023

Diabetol Metab Syndr

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Background Vitamin D supplementation exerts several supporting effects on improving glycemic status, however, results are inconclusive. Thus, in the present study, we aimed to conduct an umbrella of meta-analysis regarding the impact of vitamin D on type 2 diabetes (T2DM) biomarkers. Methods The Scopus, PubMed, Web of Science, Embase, and Google Scholar online databases were searched up to March 2022. All meta-analyses evaluating the impact of vitamin D supplementation on T2DM biomarkers were considered eligible. Overall, 37 meta-analyses were included in this umbrella meta-analysis. Results Our findings indicated that vitamin D supplementation significantly decreased fasting blood sugar (FBS) (WMD = − 3.08; 95% CI: − 3.97, − 2.19, p < 0.001, and SMD = − 0.26; 95% CI: − 0.38, − 0.14, p < 0.001), hemoglobin A1c (HbA1c) (WMD = − 0.05; 95% CI: − 0.10, − 0.01, p = 0.016, and SMD = − 0.16; 95% CI: − 0.27, − 0.05, p = 0.004), insulin concentrations (WMD = − 2.62; 95% CI: − 4.11, − 1.13; p < 0.001, and SMD = − 0.33; 95% CI: − 0.56, − 0.11, p = 0.004), and homeostatic model assessment for insulin resistance (HOMA-IR) (WMD = − 0.67; 95% CI: − 1.01, − 0.32, p < 0.001, and SMD = − 0.31; 95% CI: − 0.46, − 0.16, p < 0.001). Conclusion This umbrella meta-analysis proposed that vitamin D supplementation may improve T2DM biomarkers.

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Section: Introductionmentioning

confidence: 99%

Effect of vitamin D supplementation on type 2 diabetes biomarkers: an umbrella of interventional meta-analyses

Musazadeh

Kavyani

Mirhosseini

et al. 2023

Diabetol Metab Syndr

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“…1 Vitamin D has been known to maintaining bone health and mineral homeostasis for many decades, but recent research has shown that vitamin D receptors are present on a wide range of tissues, including the myocardium and the endothelium, proposing a much wider variety of physiological functions for vitamin. [2][3][4] Clinical and epidemiological evidence in the last decades has indicated an association between vitamin D and cardiovascular risk factors including blood pressure. 5,6 Evidence demonstrates that vitamin D may regulate blood pressure by direct vascular effect via vitamin D receptors on endothelial cells, 7 and regulating the renin-angiotensin system via effects on the juxtaglomerular apparatus.…”

Section: Introductionmentioning

confidence: 99%

<p>Association of Serum Levels of Vitamin D with Blood Pressure Status in Northern Iranian Population: The PERSIAN Guilan Cohort Study (PGCS)</p>

Joukar¹,

Naghipour²,

Hassanipour³

et al. 2020

IJGM

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Background: Evidence in the last decades has indicated an association between vitamin D and cardiovascular risk factors including blood pressure. The present study aimed to determine whether serum 25-hydroxyvitamin D is independently associated with blood pressure in a large population-based study. Methods: The study was based on subjects from PERSIAN Guilan Cohort Study (PGCS), a prospective, population-based cohort study in Guilan, Iran. In 9520 men and women, aged 35-70 years, serum 25-hydroxyvitamin D, systolic and diastolic blood pressure were measured. Multiple logistic and linear regression analyses were conducted with adjustments for demographic factors (age and gender), anthropometric characteristics (waist circumference and body mass index), lifestyle variables (physical activity, alcohol, and smoking consumption), and renal function (serum creatinine). Results: Fully adjusted linear regression analyses revealed a weak but statistically significant negative association between serum 25-hydroxyvitamin D levels and systolic blood pressure (β =-0.02, 95% CI= −0.052 to −0.0001, P-value=0.04), whereas vitamin D status was not significantly associated with diastolic blood pressure (β =-0.01, 95% CI= −0.026 to 0.009, P-value=0.3). Serum 25-hydroxyvitamin D status showed no significant association with the presence of hypertension (OR 1.09, 95% CI=0.94 to 1.25 for the lowest (25OHD <12 ng/mL) versus the highest (25OHD ≥20 ng/mL) category). Conclusion: Lower serum vitamin 25 (OH) D levels were associated with higher systolic blood pressure; however, it was not associated with diastolic blood pressure and presence of hypertension.

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“…Vitamin D is a vital element for absorption of calcium in the intestines and plays a significant role in the growth of bones along with mineral and Calcium homeostasis 9 . The commonly used indicator of Vitamin D status is serum 25 (OH) D concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D, once considered a Vitamin, is now being treated as a hormone. Many studies have demonstrated Vitamin D having effects on biological processes like calcium and phosphorus metabolism regulation as well as cell proliferation and differentiation, immune regulation and neurogenesis 9,10 . It is found to be associated with cardiovascular diseases, cancers, autoimmune and infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

Role of Vitamin D in Near Sightedness

Malik

Shabbir

et al. 2020

pak J Ophthalmol

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Purpose: To determine the levels of Vitamin D in children with myopia and to compare them with age matched controls. Study Design: Case control study. Place and Duration of Study: The study was conducted in Naseer Memorial Hospital, Dadhyal Azad Kashmir from March 2016 to March 2017. Material and Methods: Two hundred patients were selected using convenient sampling technique and were divided two groups (group I Myopic and group II control). Myopia was labeled if after subjective refraction a Spherical Equivalent (SE) of −0.50 diopters (D) or more was found. Vitamin D levels were measured by radioimmunoassay technique with Diasorin SR® kit following the user’s manual. Vitamin D levels less than 20 ng/ml were considered Vitamin D deficient following the standards of American academy of pediatrics. The collected data was entered in the statistical package for social sciences (SPSS) version 21 for analysis. Independent t–test was used to determine the significant difference of means between controls and patients. P-values less than 0.05 were considered significant. Results: Mean age of controls and myopes were 10.65 ± 3.9 and 10.20 ± 2.5 years respectively. Vitamin D levels in myopic children were found to be 14.95 ± 3.75 ng/ml and there was no significant difference in mean values of Vitamin D levels in myopic and control group. Conclusion: We found no difference in Vitamin D levels of myopic and non myopic children and concluded that Vitamin D has no role in development or progression of myopia.

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Non-Skeletal Benefits of Vitamin D

Cited by 6 publications

References 0 publications

Effect of vitamin D supplementation on type 2 diabetes biomarkers: an umbrella of interventional meta-analyses

Effect of vitamin D supplementation on type 2 diabetes biomarkers: an umbrella of interventional meta-analyses

<p>Association of Serum Levels of Vitamin D with Blood Pressure Status in Northern Iranian Population: The PERSIAN Guilan Cohort Study (PGCS)</p>

Role of Vitamin D in Near Sightedness

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