Non‐steroidal anti‐inflammatory drugs inhibit Helicobacter pylori‐induced human neutrophil reactive oxygen metabolite production in vitro

Abstract

Several NSAIDs attenuate H. pylori-induced neutrophil reactive oxygen metabolites production in vitro. This may be relevant to a potential chemopreventative role in gastric cancer and to a possible lack of synergy between H. pylori and NSAID use regarding peptic ulceration.

Influence of smoking and alcohol on gastric chemokine mRNA expression in patients with Helicobacter pylori infection

“…6 8 Active H pylori gastritis is characterised histologically by an infiltration of PMNs, 10 which are a major source of oxygen derived free radicals. 11 In our previous study, the expression of mRNA encoding the C-X-C chemokines, GRO and ENA-78, positively correlated with PMN infiltration in H pylori positive gastric mucosa. 5 The increased expression of C-X-C chemokine mRNA in smokers could account for the increased PMN infiltration in their gastric mucosa.…”

Non‐steroidal anti‐inflammatory drugs have bacteriostatic and bactericidal activity against Helicobacter pylori

“… 20,21 Moreover, H. pylori ‐associated gastric carcinogenesis in mice has been significantly decreased by long‐term treatment with the anti‐inflammatory drug nimesulide 22 . Because distal gastric cancer is strongly associated with H. pylori, 23,24 it is also conceivable that NSAIDs may provide some protection against gastric cancer by inhibiting H. pylori ‐induced neutrophil reactive oxygen metabolite production 25 or even by directly inhibiting the viability and/or growth of H. pylori 26,27 …”

Production of Reactive Oxygen Species in Peripheral Blood is Increased in Individuals with Helicobacter pylori Infection and Decreased after its Eradication

“…Thus, the effects of infection and/or inflammation caused by pathogens other than H. pylori were negligible in these three patients. It is known that ROS generation by neutrophils is affected by various factors, such as age [25], sex [26], smoking [27], alcohol ingestion [28], and use of medications [29]. We therefore examined the correlations between ROS production and these factors (Fig.…”