Nonalcoholic fatty liver disease is an independent risk factor for atherosclerosis in young adult men

Öztürk, Kayhan; Uygun, Ahmet; Güler, Ahmet; Demirci, Hakan; Özdemir, Cafer; Çakır, Mehmet Volkan; Sakin, Yusuf Serdar; Türker, Türker; Sarı, Sebahattin; Demirbaş, Şeref; Karslioğlu, Yıldırım; Sağlam, Mutlu

doi:10.1016/j.atherosclerosis.2015.04.009

Cited by 71 publications

(44 citation statements)

References 38 publications

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“…However, almost all previous studies used ultrasonography to diagnose NAFLD and none used TE to detect advanced liver fibrosis. Of note, only two previous cross‐sectional studies included patients with biopsy‐proven NAFLD, with opposite results: the first one showed positive independent associations between histological liver fibrosis score and cf‐PWV in 100 patients, whereas the second one did not demonstrate any association between liver fibrosis and arterial stiffness in 61 patients with NAFLD. Our results corroborate with the first study results .…”

Section: Discussionmentioning

confidence: 90%

“…Some previous studies have demonstrated significant and independent associations between the presence of NAFLD and increased arterial stiffness ; the largest of them with 8632 individuals from a Chinese population‐based sample. All of them demonstrated that individuals with NAFLD had increased arterial stiffness than their counterparts without NAFLD, and that this association was independent of traditional cardiovascular risk factors, particularly of metabolic syndrome or of its isolated components.…”

Section: Discussionmentioning

confidence: 99%

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Increasing aortic stiffness is predictive of advanced liver fibrosis in patients with type 2 diabetes: the Rio‐T2DM cohort study

Leite

Villela-Nogueira

Ferreira

et al. 2015

Liver International

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Increasing aortic stiffness is predictive of advanced liver fibrosis in patients with type 2 diabetes: the Rio‐T2DM cohort study

Leite

Villela-Nogueira

Ferreira

et al. 2015

Liver International

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“…In addition, NAFLD is an independent risk factor for atherosclerosis. The presence of NAFLD leads to an increased risk of endothelial dysfunction,16 and further to cardiovascular disease and cerebrovascular diseases. The presence of NAFLD will exacerbate the progression of physical diseases such as cirrhosis, hepatic carcinoma, cardiovascular disease, and cerebrovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

The prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease

Yan¹,

Hou²,

Liang³

2017

NDT

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ObjectiveIn this study, we compared the prevalence rate of non-alcoholic fatty liver disease (NAFLD) between young males with schizophrenia and the general young males as the control group, and we also investigated the risk factors of NAFLD in young males with schizophrenia.Materials and methodsThis is a large cross-sectional study consisting of the study group and parallel control group. The study group comprises 202 cases of young males with schizophrenia recruited from Liaoning province Demobilized Soldiers Kangning Hospital, and 149 healthy young males were recruited as the control group. The clinical evaluation included Positive and Negative Syndrome Scale (PANSS), basic information, disease-related information, and physical examination information. The laboratory tests included fasting blood glucose, total cholesterol, triglyceride, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). The physical examination included liver ultrasonography.ResultsNo statistical difference was observed between the study and control groups regarding age (30.5±3.9 vs 30.7±3.6), body mass index (BMI), blood pressure, fasting glucose level, and total cholesterol. NAFLD was observed in both the study and control groups. The prevalence of NAFLD was 49.5% (100/202) in the study group, and 20.1% (30/149) in the control group. The study group was further divided into NAFLD group and non-NAFLD group. There were significant differences in medication combination, drug dosage, negative factor score in PANSS (14.1±4.0 vs 12.7±4.5), BMI, fasting glucose level, total cholesterol, triglyceride, ALT, and AST between NAFLD group and non-NAFLD group. According to the results of the multiple-factor analysis, the onset of NAFLD among young males with schizophrenia was significantly correlated with the following factors: triglyceride, BMI, medication combination, drug dosage, and negative factor score in PANSS.ConclusionThe prevalence of NAFLD in the study group was significantly higher than that in the control group. Multivariate analysis indicated that, triglyceride, BMI, medication combination, drug dosage, and negative factor score in PANSS were significantly related to NAFLD in patients with schizophrenia.

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“…Non-alcoholic fatty liver disease is considered a multisystem disease [6], backed up by the fact that the most common cause of mortality in NAFLD is cardiovascular mortality [7,8]. Evidence has accumulated suggesting a strong association between NAFLD and cardiovascular disease (CVD), for example different manifestations of subclinical atherosclerosis such as increased carotid intima-media thickness and carotid atherosclerosis [9,10], endothelial dysfunction [11], arterial stiffness [12], impaired left ventricular function [13], and coronary calcification [9,14]. In addition, increased serum levels of common markers of liver injury (γ-glutamyltransferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AP), and bilirubin) are associated with greater risk of CVD events [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Liver parameters as part of a non-invasive model for prediction of all-cause mortality after myocardial infarction

Baars

Sowa

Neumann

et al. 2020

aoms

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Introduction: Liver parameters are associated with cardiovascular disease risk and severity of stenosis. It is unclear whether liver parameters could predict the long-term outcome of patients after acute myocardial infarction (AMI). We performed an unbiased analysis of the predictive value of serum parameters for long-term prognosis after AMI. Material and methods: In a retrospective, observational, single-center, cohort study, 569 patients after AMI were enrolled and followed up until 6 years for major adverse cardiovascular events, including cardiac death. Patients were classified into non-survivors (n = 156) and survivors (n = 413). Demographic and laboratory data were analyzed using ensemble feature selection (EFS) and logistic regression. Correlations were performed for serum parameters.

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Nonalcoholic fatty liver disease is an independent risk factor for atherosclerosis in young adult men

Cited by 71 publications

References 38 publications

Increasing aortic stiffness is predictive of advanced liver fibrosis in patients with type 2 diabetes: the Rio‐T2DM cohort study

Increasing aortic stiffness is predictive of advanced liver fibrosis in patients with type 2 diabetes: the Rio‐T2DM cohort study

The prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease

Liver parameters as part of a non-invasive model for prediction of all-cause mortality after myocardial infarction

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