Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells

Abstract

Human hair follicle dermal papilla cells (DPCs) are a specialized population of cells located in the hair follicles and regulate hair growth and development, particularly by releasing numerous growth factors in response to various physiological conditions. In the present study, we aimed to test whether nonanal, a scent compound from plants, stimulated growth factors in DPCs and to delineate the underlying mechanisms involved. We found that nonanal promoted DPC proliferation in a dose-dependent manner. Meanwhile, it also increased the intracellular cyclic adenosine monophosphate (cAMP) levels and the expression of various growth factor genes such as vascular endothelial growth factor, keratinocyte growth factor, and insulin-like growth factor 1. Furthermore, nonanal treatment stimulated DPC migration. Notably, the benefits of nonanal use were abrogated by cAMP inhibition. Our results reveal the potential of nonanal in preventing hair loss and suggest that its effects are cAMP-mediated in DPCs.

Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism

“…S2, A to C). On the basis of the previous studies, we measured metabolites that promote hair follicle growth, including gallic acid, α-ketoglutarate, inosine, inosine monophosphate, spermidine, and spermine ( 27 – 30 ). Likewise, we found that these metabolites did not exhibit a significantly consistent trend with the bacterial load of the skin at any tested time point (fig.…”

Chemical Composition of Miscanthus sinensis var. purpurascens Flower Absolute and Its Beneficial Effects on Skin Wound Healing and Melanogenesis‐Related Cell Activities

“…Of the six identified peaks, the largest GC peak was assigned to dotriacontanol (peak 6, 48.72 %), followed in descending order by nonadecane (peak 3, 21.84 %), tridecanal (peak 2, 10.69 %), 2‐octyl‐1‐dodecanol (peak 5, 10.40 %), 1,2‐epoxyoctadecane (peak 4, 5.12 %), and nonanal (peak 1, 3.22 %) ( Figure 1 and Table 1). Of these compounds, nonanal has been reported to induce the migration and proliferation of human hair follicle dermal papilla cells, [16] but other compounds are not known about their bioactivities on dermal cell types. These observations imply that MSPFAb may influence the migratory and/or proliferative activities of dermal cell types such as keratinocytes.…”

Chemical Composition of Salix koreensis Anderss Flower Absolute and Its Skin Wound Healing Activities In Vitro

“…Several of the compounds identified were associated with migratory or proliferative activity against various types of cells. For example, a literature search revealed that one of these components, nonanal, enhanced proliferative and migratory activities and upregulated growth factor genes, such as keratinocyte growth factor in human hair follicle dermal papilla cells [ 31 ]. Verbenone had an antiproliferative effect on ovarian carcinoma cells [ 32 ].…”