Nonenzymatic electrochemical sensors via Cu native oxides (CuNOx) for sweat glucose monitoring

Alam, Maksud M.; Howlader, M. M. R.

doi:10.1016/j.sbsr.2021.100453

Cited by 21 publications

(35 citation statements)

References 101 publications

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“…In the calibration curve shown in Figure 10 B, it can be seen that the sensor exhibits a linear range of up to 2 mM glucose, with R 2 = 0.9979, a sensitivity of 21.02 µA/mM·cm −2 , and a limit of detection (LOD) of 5.2 µM, values calculated based on the 3σ/slope equation, where σ represents the standard deviation of the blank. Actually, the LOD reported in this work is lower than that of other copper-based glucose sensors, such as Cu(II)/rGO/SPCE (65 µM) [ 17 ], Cu nanobelts (10 µM) [ 10 ], Cu-DA (20 µM) [ 39 ], Cu 2 O/PtE (26 µM) [ 40 ], Cu 2 O/Cu microstructures (37 µM) [ 33 ], CuNOx thin films (94.21 µM) [ 41 ], CuO nanowires (10 µM) [ 2 ], CuO nanorods/Nafion/GCE (23 µM) [ 12 ], and CuO nanoplatelets/Nafion/GCE (29 µM) [ 12 ]. Copper-based glucose sensors with an LOD lower than 5.2 µM have been reported in other works [ 9 , 15 , 35 ]; however, more often, their synthesis involves laborious processes and the use of hazardous products or elevated temperatures, not suitable for mass production, compared to DC sputtering, which is a clean and easy-to-scale-up method.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Copper Nanostructures for Non-Enzymatic Glucose Sensors via Direct-Current Magnetron Sputtering

et al. 2022

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In this paper, Cu nanocolumnar structure electrodes are synthetized using a clean and easy-to-scale-up direct-current magnetron sputtering (DC-MS) technique for non-enzymatic glucose sensing. The nanocolumnar structure increases the active surface area of the deposit, with the nanocolumns showing a mean size diameter of 121.0 nm ± 27.2 and a length of 2.52 µm ± 0.23. A scanning transmission electron (STEM) analysis shows the presence of Cu and a small amount of Cu2O. The behavior of the electrodes in alkaline environments and the electrochemical affinity of the Cu nanocolumns (CuNCs) towards the electro-oxidation of glucose are investigated using cyclic voltammetry (CV). After performing CV in NaOH solution, the columnar structures present corrosion products containing Cu2O, as revealed by STEM and X-ray diffraction (XRD) analyses. The amperometric responses of the CuNCs to the successive addition of glucose show a linear range up to 2 mM and a limit of detection of 5.2 µM. Furthermore, the electrodes are free from chloride poisoning, and they are insensitive to dopamine, uric acid, ascorbic acid, and acetaminophen at their physiological concentrations.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Copper Nanostructures for Non-Enzymatic Glucose Sensors via Direct-Current Magnetron Sputtering

et al. 2022

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“…Wearable electrochemical sensors for

-THC and CBD require further research and development to create POC devices. These devices typically require sensing electrodes, microfluidic and filtering systems, electronics, and wireless communication for data transmission [ 62 , 63 , 64 , 65 , 66 ]. However, integrating all of these components to create small, non-invasive platforms is not easy [ 62 , 65 , 66 , 67 , 68 ].…”

Section: Research Challenges and Future Perspectivesmentioning

confidence: 99%

Nanomaterials-Based Electrochemical Δ9-THC and CBD Sensors for Chronic Pain

2023

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Chronic pain is now included in the designation of chronic diseases, such as cancer, diabetes, and cardiovascular disease, which can impair quality of life and are major causes of death and disability worldwide. Pain can be treated using cannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) due to their wide range of therapeutic benefits, particularly as sedatives, analgesics, neuroprotective agents, or anti-cancer medicines. While little is known about the pharmacokinetics of these compounds, there is increasing interest in the scientific understanding of the benefits and clinical applications of cannabinoids. In this review, we study the use of nanomaterial-based electrochemical sensing for detecting Δ9-THC and CBD. We investigate how nanomaterials can be functionalized to obtain highly sensitive and selective electrochemical sensors for detecting Δ9-THC and CBD. Additionally, we discuss the impacts of sensor pretreatment at fixed potentials and physiochemical parameters of the sensing medium, such as pH, on the electrochemical performance of Δ9-THC and CBD sensors. We believe this review will serve as a guideline for developing Δ9-THC and CBD electrochemical sensors for point-of-care applications.

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“…Sweat glucose analysis is probably the most interesting noninvasive method, as it is the base of wearable glucose sensors intended for continuous glucose level monitoring. Alam and Howlader (2021) invented a non-enzymatic glucose sensor based on native copper oxide on copper foil (41). A glucose sensor based on a glassy carbon electrode with low-density polyethylene and covalently immobilized glucose oxidase was designed for the analysis of sweat glucose by Fabregat and co-authors (2021) (42).…”

Section: Non-invasive and Portable Glucose Biosensorsmentioning

confidence: 99%

The latest trends in the design of electrochemical biosensors for the diagnosis and monitoring of diabetes mellitus

Valkova¹,

Pohanka²

2022

BLL

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AIMS: This review article focuses on electrochemical biosensors in the diagnosis of diabetes mellitus and their latest trends and advances. In particular, non-enzymatic, non-invasive, wearable, and non-glucose biosensors are described. METHODS: The current literature was searched and recent works on this matter were cited and discussed in the text of this paper. RESULTS: The overworld health problem, the incurable disease, the global burden on health insurers and society, and above all one of the leading causes of death -all characterize diabetes mellitus, a lifelong chronic disease that affects hundreds of millions of people around the world. The new types of biosensors bring new opportunities in the care of diabetic patients and improve current methods. The practical relevance of the recent fi ndings is expected in medicine in next years. CONCLUSIONS: The authors summarized the modern possibilities of biosensing, their pros and cons, and their perspectives for the future. The discussion outcome from the current literature (Tab. 4, Fig. 1, Ref. 63).

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Nonenzymatic electrochemical sensors via Cu native oxides (CuNOx) for sweat glucose monitoring

Cited by 21 publications

References 101 publications

Synthesis of Copper Nanostructures for Non-Enzymatic Glucose Sensors via Direct-Current Magnetron Sputtering

Synthesis of Copper Nanostructures for Non-Enzymatic Glucose Sensors via Direct-Current Magnetron Sputtering

Nanomaterials-Based Electrochemical Δ9-THC and CBD Sensors for Chronic Pain

The latest trends in the design of electrochemical biosensors for the diagnosis and monitoring of diabetes mellitus

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