Nonenzymatic Glucose Sensing Using Ni₆₀Nb₄₀Nanoglass

Abstract

Despite being researched for nearly five decades, chemical application of metallic glass is scarcely explored. Here we show electrochemical nonenzymatic glucose-sensing ability of nickel–niobium (Ni60Nb40) amorphous alloys in alkaline medium. Three different Ni60Nb40 systems with the same elemental composition, but varying microstructures are created following different synthetic routes and tested for their glucose-sensing performance. Among melt-spun ribbon, nanoglass, and amorphous–crystalline nanocomposite materials, nanoglass showed the best performance in terms of high anodic current density, sensitivity (20 mA cm–2 mM–1), limit of detection (100 nM glucose), stability, reproducibility (above 5000 cycles), and sensing accuracy among nonenzymatic glucose sensors involving amorphous alloys. When annealed under vacuum, only the heat-treated nanoglass retained a similar electrochemical-sensing property, while the other materials failed to yield desired results. In nanoglass, a network of glassy interfaces, compared to melt-spun ribbon, is plausibly responsible for the enhanced sensitivity.

Electrochemical non-enzymatic glucose sensors: recent progress and perspectives

“…Soumabha et al used Ni 60 Nb 40 nanoglass to construct an electrochemical sensor with a linear range of 0.0001-10 mM. 217 Wu et al fabricated a glucose sensor based on NiCo/NiCoO x hybrid nanoclusters with a linear range of 0.001-8 mM. 57 Yuan et al constructed a sensor with the linear range of 2-14 mM using a platinum-nanotubule array.…”

Recent advances in biomedical, biosensor and clinical measurement devices for use in humans and the potential application of these technologies for the study of physiology and disease in wild animals

“…Enzymes lose activity over time and this is a key limitation on wearable glucose monitors (to circumvent this issue, replacement sensors are used every few months). Recent examples of non-enzymatic glucose biosensors include: a system on a glass substrate composed of hydrothermally grown CuO nanorods decorated with Au nanoparticles and used to detect glucose levels in saliva [71]; the development of a metal oxide sensor induced by an electrical potential to non-enzymatically detect glucose in artificial tears via wireless connection [72]; and use of a Ni 60 Nb 40 amorphous nanoglass composite to non-enzymatically detect glucose with 100 nM sensitivies, opening up the potential of using nickel-based nanoglasses in wearable sensors [73]. All of these systems are offering the sensitivity and selectivity required to measure glucose in blood, sweat and interstitial fluid and so it seems inevitable that products based on this approach will reach the blood glucose monitoring market.…”

Silica‐Templated Metal Organic Framework‐Derived Hierarchically Porous Cobalt Oxide in Nitrogen‐Doped Carbon Nanomaterials for Electrochemical Glucose Sensing

“…Though GOD‐based biosensors have been investigated to operate in a wide pH range, the lifetime of these enzymatic sensors is still severely limited by the instability of the enzyme affected by temperature [7] . Based on these shortcomings, researches have begun to focus on the establishment of non‐enzymatic sensors, which usually combine nanostructured materials with conductive support materials to improve the sensing performance, thus achieving a lower initial potential, higher sensitivity and stability [8,9] . Besides, in the past few decades, non‐enzymatic sensors have been fully studied and reported to be based on different transducers, such as photothermal, [10,11] acoustic, [12] magnetic, [13] electrochemical, [14] etc.…”