Electrochemical non-enzymatic glucose sensors: recent progress and perspectives

Wei, Mu-Xin; Qiao, Yanxia; Zhao, Haitao; Liang, Jie; Li, Tingshuai; Luo, Yonglan; Lu, Siyu; Shi, Xifeng; Lu, Wenbo

doi:10.1039/d0cc05650b

Cited by 314 publications

(183 citation statements)

References 218 publications

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“…[ 2,3 ] On the whole, NLRs can transduce both concentration and type information of metal ions into color signals, achieving non‐enzymatic biosensing. [ 62–64 ] By processing these signals, the detection of trace Fe 2+ was achieved with remarkable performance (Figure S17, Supporting Information), indicating the feasibility of NLRs as the element for signal transduction. Furthermore, OPD and ABTS were used as the signal molecules as well ( Figure a–c).…”

Section: Resultsmentioning

confidence: 99%

Defect‐Engineered Nanozyme‐Linked Receptors

Wen

et al. 2021

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Though nanozymes are successfully applied in various areas, the increasing demands facilitate the exploitation of nanozymes possessing higher activity and more functions. Natural enzyme‐linked receptors (ELRs) are critical components for signal transductions in vivo by expressing activity variations after binding with ligands. Inspired by this, the defect‐engineered carbon nitrides (DCN) are reported to serve as nanozyme‐linked receptors (NLRs). For one thing, cyano defects increase the enzyme‐like activity by a factor of 109.5. For another, DCN‐based NLRs are constructed by employing cyano groups as receptors, and variable outputs are ensued upon the addition of ion ligands. Significantly, both the cascade effect and electronic effect are demonstrated to contribute to this phenomenon. Finally, NLRs are used for pattern recognition of metal ions, indicating the signal transduction ability of NLRs as well. This work not only provides great promise of defect engineering in nanozymes, but also contributes to the design of artificial ELRs.

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Section: Resultsmentioning

confidence: 99%

Defect‐Engineered Nanozyme‐Linked Receptors

Wen

et al. 2021

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“…To the best of our knowledge, this article is the first to analyze and summarize such phenomena. This article pays great attention to the interface modulation of nucleic acids to nanozymes: modification, binding, immobilization, and the resulting major changes in interface components in the structure of nanozymes, which lead to an increase or decrease in enzyme catalytic activity [46][47][48][49][50]. The controllability and accuracy of modulation technology is an important force for promoting the progress of social civilization.…”

Section: Nucleic Acid Modulation For Functional Nanozymementioning

confidence: 99%

Recent Advances in Nucleic Acid Modulation for Functional Nanozyme

Wang

Cheng

et al. 2021

Catalysts

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Nanozymes have the potential to replace natural enzymes, so they are widely used in energy conversion technologies such as biosensors and signal transduction (converting biological signals of a target into optical, electrical, or metabolic signals). The participation of nucleic acids leads nanozymes to produce richer interface effects and gives energy conversion events more attractive characteristics, creating what are called “functional nanozymes”. Since different nanozymes have different internal structures and external morphological characteristics, functional modulation needs to be compatible with these properties, and attention needs to be paid to the influence of nucleic acids on nanozyme activity. In this review, “functional nanozymes” are divided into three categories, (nanozyme precursor ion)/ (nucleic acid) self-assembly, nanozyme-nucleic acid irreversible binding, and nanozyme-nucleic acid reversible binding, and the effects of nucleic acids on modulation principles are summarized. Then, the latest developments of nucleic acid-modulated nanozymes are reviewed in terms of their use in energy conversion technology, and their conversion mechanisms are critically discussed. Finally, we outline the advantages and limitations of “functional nanozymes” and discuss the future development prospects and challenges in this field.

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“…Among them, electrochemical methods are widely anticipated because of the facile preparation, fast response, low signal‐to‐noise and cost. In this context, electrochemical sensors based on non‐enzymatic nanomaterials for efficient glucose detection have attracted widespread attention [15,16] …”

Section: Figurementioning

confidence: 99%

Silica‐Templated Metal Organic Framework‐Derived Hierarchically Porous Cobalt Oxide in Nitrogen‐Doped Carbon Nanomaterials for Electrochemical Glucose Sensing

et al. 2021

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As glucose molecules are well recognized to supplement the main energy source of living cells as the intermediate product of metabolism in human body, it is of great importance to develop a convenient and quantitative glucose sensor with high selectivity, high sensitivity, and high accuracy. In this work, a simple and novel strategy has been developed to obtain a high‐performance non‐enzymatic glucose sensor by constructing hierarchically porous Co3O4 embedded into the metal organic framework (MOF)‐derived N‐doped carbon matrix based on a SiO2 template, denoted as ST‐Co3O4. The removal of the SiO2 template creates abundant voids and a large specific surface for the obtained layered mesoporous ST‐Co3O4 composite, which enhances the electron transfer kinetics and the ability to adsorb biomolecules, further greatly improving the surface reaction efficiency and promoting the improvement of its catalytic performance. Compared with pure Co3O4 nanoparticles from ZIF‐67 without a silica template, as‐obtained ST‐Co3O4 shows a good mesoporous environment, provides more active sites, and makes the non‐enzymatic glucose sensor exhibit high sensitivity (2860 μA mM−1 cm−2) and fast response time (<1 s) over a wide linear glucose concentration range of 1.0–1300.0 μM. Additionally, the ST‐Co3O4/CC electrode demonstrates good anti‐interference, high repeatability, and robust stability (>3000 s), which can repeatedly detect the glucose species in real human serum (RSD<9.69 %, n=3), and shows broad prospects in non‐enzymatic sensors.

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Electrochemical non-enzymatic glucose sensors: recent progress and perspectives

Abstract: The detection of glucose has important significance in clinical medicine and food industry, especially in the diagnosis of diabetes. In recent years, electrochemical non-enzymatic glucose sensors have attracted intensive attention...

Cited by 314 publications

References 218 publications

Defect‐Engineered Nanozyme‐Linked Receptors

Defect‐Engineered Nanozyme‐Linked Receptors

Recent Advances in Nucleic Acid Modulation for Functional Nanozyme

Silica‐Templated Metal Organic Framework‐Derived Hierarchically Porous Cobalt Oxide in Nitrogen‐Doped Carbon Nanomaterials for Electrochemical Glucose Sensing

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