Nonhuman Primates and other Animal Models in Diabetes Research

Harwood, H. James; Listrani, Paul; Wagner, Janice D.

doi:10.1177/193229681200600304

Cited by 74 publications

(80 citation statements)

References 159 publications

(247 reference statements)

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“…Estos modelos se clasifican mayoritariamente en base al tipo de diaebetes que padecen, o en la manera en la que esta se produce, siendo los dos grupos mayores de clasificación los modelos espontáneos o inducidos [92,[103][104][105][106][107][108].…”

Section: Patogénesis De La Dm1unclassified

Study of the pathogenesis and treatment of diabetes mellitus through animal models

Brito‐Casillas

Melián

Wägner

2016

Endocrinología y Nutrición

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Section: Patogénesis De La Dm1unclassified

Study of the pathogenesis and treatment of diabetes mellitus through animal models

Brito‐Casillas

Melián

Wägner

2016

Endocrinología y Nutrición

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“…Citation: Wang X, Wang B, Sun G, Wu J, Liu Y, et al (2015) This article introduces the characteristics of one NHP diabetic model, naturally occurring diabetes, which has been highly valuable for research and treatment of dyslipidemia and dysglycemia [14][15][16][17]. Other NHP models, such as diet-induced dyslipidemia and dysglycemia and streptozocin-induced diabetes, developed in our facility will be introduced lately via other manuscripts.…”

Section: Journal Of Diabetes and Metabolismmentioning

confidence: 99%

“…Typically, animal models have excellent predictive validity whereby drug-induced weight loss subsequently translates to weight loss in man [12,13]. Currently, more studies related to obesity/diabetes research are moving toward using non-human primates (NHPs) which have better patho-physiological metabolism similarities to humans [14,15]. NHP models also play an important role in the screening of novel compounds for regulation of food intake, blood glucose and/or body weight, which can result in discovery and validation of new mechanism and therapeutic strategy or target [16,17].…”

Section: Introductionmentioning

confidence: 99%

Dysglycemia and Dyslipidemia Models in Nonhuman Primates: Part I. Model of Naturally Occurring Diabetes

Wang¹,

Wang²,

Sun³

et al. 2015

J Diabetes Metab

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Insulin-resistant diabetes (Type 2 diabetes mellitus, T2DM) is one of the main comorbidities of obesity and is the most common form of diabetes. T2DM and obesity dynamically influence each other and often escalate patients' other health issues. Cardiovascular, renal and other health consequences of obesity and diabetes have been studied for several decades. However, the underlying precise mechanisms and interactions of obesity and insulin-resistant diabetes have yet to be elucidated further. It has been recognized that sustained greater energy intake than expenditure is the main cause of obesity that can potentially lead to insulin resistance and diabetes due to excessive fat accumulation. To better understand the pathophysiology of human obesity and diabetes, nonhuman primate (NHP) models have been used for research to delineate molecular and cellular mechanisms because of the similarity of the metabolic diseases between NHP and humans. Also, NHP models have been well used for testing new novel therapies, which provides critical pre-clinic information for drug discovery. This article summarizes the data collected from a large scale of the naturally occurring diabetes monkeys housed in our facility. Manuscripts for other NHP models, such as diet-induced dyslipidemia and dysglycemia and streptozocin-induced diabetes, developed in our facility will follow lately. Dysglycemia and Dyslipidemia Models in Journal of Diabetes and MetabolismCitation: Wang X, Wang B, Sun G, Wu J, Liu Y, et al. (2015) This article introduces the characteristics of one NHP diabetic model, naturally occurring diabetes, which has been highly valuable for research and treatment of dyslipidemia and dysglycemia [14][15][16][17]. Other NHP models, such as diet-induced dyslipidemia and dysglycemia and streptozocin-induced diabetes, developed in our facility will be introduced lately via other manuscripts. While no single model is necessarily applicable to every dysmetabolic research program and drug discovery, it has been suggested that certain models have great validity. Therefore, if possible, selectively using of those preferable models to achieve the best potential outcome is recommended in order to address the very challenging diseases, obesity and diabetes. Normal and obese/diabetic monkeys housed in our animal center are collected periodically from the monkey farms in China and then raised in our own facility with a normal calorie monkey chow (Beijing Keao Xieli Feed Co., LTD, Beijing, China) enriched with seasonal fruits and vegetables in accordance with the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) regulations and guidelines [18][19][20]. All the procedures for sample or data collection used in this study were approved by the Institutional Animal Care and Use Committee (IACUC) (Crown Bioscience, Inc., Taicang, Jiangsu province, The People's Republic of China) [18][19][20]. Animal grouping and their general characteristicsAs humans and other great apes (Hominoidea) diverged from Old World m...

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“…This article introduces the characteristics of obesity models in our housed cynomolgus monkeys (Macaca fascicularis), naturally occurring and experimental induction, which have been highly valuable for research and treatment of dyslipidemia and dysglycemia [18][19][20][21]. Other NHP models, such as naturally occurring diabetes (see our recently published paper) and streptozocin-induced diabetes developed in our facility, are introduced elsewhere [22,23].…”

Section: Distribution and Correlation In Naturally Obese Monkeysmentioning

confidence: 99%

“…Currently, more studies related to obesity/diabetes research are moving toward using non-human primates (NHPs) which have better pathophysiological metabolism similarities to humans [18,19]. NHP models also play an important role in the screening of novel compounds for regulation of food intake, blood glucose and/or body weight, which can result in discovery and validation of new mechanism and therapeutic strategy or target [19][20][21]. Compared with humans, NHPs are more accessible and feasible for biopsy and histopathology if there are scientific needs with IACUC approval.…”

Section: Distribution and Correlation In Naturally Obese Monkeysmentioning

confidence: 99%

Dysglycemia and Dyslipidemia Models in Nonhuman Primates: Part II. Model of Naturally Occurring or Experimental Obesity

Wang¹,

Sun²

2015

J Diabetes Metab

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Obesity is viewed as one of the most serious public health issues of this century, which is likely due to economic growth, urbanization, modernization, life-style change and decreased physical activity. In 2013, the American Medical Association classified obesity as a disease. Sustained excessive accumulation of body fat to the extent, such as overweight or obesity, can reduce life expectancy and increase health risks, particularly heart disease and type 2 diabetes. Cardiovascular, diabetes and other health problems of obesity have been studied for many decades. Inflammation, mitochondrial dysfunction, hyperinsulinemia, lipotoxicity, medical and others, such as genetic background and aging, may result in obesity. However, the underlying precise mechanisms have yet to be elucidated further. Various obesity animal models have been used and induced for obesity research and therapy. To better understand the pathophysiology of human obesity, corpulent nonhuman primates (NHPs) are useful models due to resembling humans, not only physiologically but in eating habits (bored-eat). NHP obesity models have been developed and used for delineating molecular and cellular mechanisms and for testing new novel therapies, which provides critical pre-clinic information for drug discovery. We recently published the data obtained from naturally occurring diabetes NHPs. This article summarizes the data collected from a large scale of naturally occurring and high calorie (fat) diet (HCD)-induced obesity monkeys housed in our facility. Manuscript for another NHP model, streptozocin-induced diabetes, developed in our facility will follow lately.

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Nonhuman Primates and other Animal Models in Diabetes Research

Cited by 74 publications

References 159 publications

Study of the pathogenesis and treatment of diabetes mellitus through animal models

Study of the pathogenesis and treatment of diabetes mellitus through animal models

Dysglycemia and Dyslipidemia Models in Nonhuman Primates: Part I. Model of Naturally Occurring Diabetes

Dysglycemia and Dyslipidemia Models in Nonhuman Primates: Part II. Model of Naturally Occurring or Experimental Obesity

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