Nonionic Surfactant Vesicles (Niosomes) of Cytarabine Hydrochloride for Effective Treatment of Leukemias: Encapsulation, Storage, and In Vitro Release

Ruckmani, K.; Jayakar, B.; Ghosal, Sanjoy

doi:10.1081/ddc-100100348

Cited by 81 publications

(38 citation statements)

References 13 publications

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“…Upon incorporation of DCP, increase in cholesterol molar ratio from 0.5 to 1 (F7 and F8) showed increase in vesicle permeability It is to be noted that the in vitro release results are consistent with those of the entrapment efficiency, as the niosomes composed of Tween 60, cholesterol and DCP (1:1:0.1) molar ratio with the highest entrapment efficiency (92.02%) showed the lowest drug release percent after 8 h (Q 8h =66.29%). The comparative release data indicate that, by encapsulation of drug into niosomes, it is possible to sustain and control the release of the drug for a longer duration (22). …”

Section: Determination Of Vesicle Sizementioning

confidence: 99%

Niosome-Encapsulated Gentamicin for Ophthalmic Controlled Delivery

2008

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Abstract. The objective of the present research was to investigate the feasibility of using non-ionic surfactant vesicles (niosomes) as carriers for the ophthalmic controlled delivery of a water soluble local antibiotic; gentamicin sulphate. Niosomal formulations were prepared using various surfactants (Tween 60, Tween 80 or Brij 35), in the presence of cholesterol and a negative charge inducer dicetyl phosphate (DCP) in different molar ratios and by employing a thin film hydration technique. The ability of these vesicles to entrap the studied drug was evaluated by determining the entrapment efficiency %EE after centrifugation and separation of the formed vesicles. Photomicroscopy and transmission electron microscopy as well as particle size analysis were used to study the formation, morphology and size of the drug loaded niosomes. Results showed a substantial change in the release rate and an alteration in the %EE of gentamicin sulphate from niosomal formulations upon varying type of surfactant, cholesterol content and presence or absence of DCP. In-vitro drug release results confirmed that niosomal formulations have exhibited a high retention of gentamicin sulphate inside the vesicles such that their in vitro release was slower compared to the drug solution. A preparation with 1:1:0.1 molar ratio of Tween 60, cholesterol and DCP gave the most advantageous entrapment (92.02%±1.43) and release results (Q 8h =66.29%±1.33) as compared to other compositions. Ocular irritancy test performed on albino rabbits, showed no sign of irritation for all tested niosomal formulations.

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Section: Determination Of Vesicle Sizementioning

confidence: 99%

Niosome-Encapsulated Gentamicin for Ophthalmic Controlled Delivery

2008

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“…Encapsulation of drug in niosomal formulations reduces the toxicity in various therapies and applications and also prolongs the encapsulated drug circulation time and changes drug distribution in the body (Azmin et al, 1985;Baillie et al, 1985;Ruckmani et al, 2002). Drug delivery through niosomes has been studied using different methods of administration (Blazek-Welsh & Rhodes, 2001b), including intravenous (i.v.)…”

Section: Proniosomes As Drug Carriersmentioning

confidence: 99%

A review on novel vesicular drug delivery: proniosomes

et al. 2013

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Nanotechnology has brought a revolution in the field of science, which has subsequently lead to development of novel dosage forms such as niosomes, liposomes and proniosomes. Proniosomes overcome the demerits involved with niosomal and liposomal drug delivery systems. Proniosomes are liquid crystalline compact niosome hybrids which upon hydration form niosomes. They help in reducing physical stability problems involved with niosomes such as leaking, fusion, aggregation and provide convenience in dosing, distribution, transportation and storage showing improved results than conventional niosomes. This review focuses on different aspects of proniosome such as preparation, characterization, drug release, applications, merits, demerits, present scenario in market and future trends.

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“…Niosomes have been successfully used in drug targeting to various organs such as skin (Agarwal et al, 2001), brain (Abdelkader et al, 2012), liver (Baillie et al, 1986;Lala et al, 2004), lung (Desai et al, 2002;Abd-Elbary et al, 2008) ocular systems (Pugeat et al, 1991;Abdelkader et al, 2012), tumor (Ruckmani et al, 2000;Shi et al, 2005) etc. Niosomes show a higher bioavailability than conventional dosage forms (Raja Naresh et al, 1994).…”

Section: Application Of Niosomementioning

confidence: 99%