Nonparametric Diagnostic Test for Conditional Logistic Regression

Goodman, Melody S.; Li, Yang

doi:10.4172/2155-6180.1000136

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Model discrimination and calibration were assessed using standard logistic regression methods, since current statistical software is unable to calculate diagnostic measures that account for the matched design. 30,31 All statistical analyses were performed using SAS version 9.4 (SAS Institute, USA), and hypothesis testing was two-sided.…”

Section: Methodsmentioning

confidence: 99%

Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade and Postoperative Pulmonary Complications (STRONGER)

et al. 2020

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Background Five percent of adult patients undergoing noncardiac inpatient surgery experience a major pulmonary complication. The authors hypothesized that the choice of neuromuscular blockade reversal (neostigmine vs. sugammadex) may be associated with a lower incidence of major pulmonary complications. Methods Twelve U.S. Multicenter Perioperative Outcomes Group hospitals were included in a multicenter observational matched-cohort study of surgical cases between January 2014 and August 2018. Adult patients undergoing elective inpatient noncardiac surgical procedures with general anesthesia and endotracheal intubation receiving a nondepolarizing neuromuscular blockade agent and reversal were included. Exact matching criteria included institution, sex, age, comorbidities, obesity, surgical procedure type, and neuromuscular blockade agent (rocuronium vs. vecuronium). Other preoperative and intraoperative factors were compared and adjusted in the case of residual imbalance. The composite primary outcome was major postoperative pulmonary complications, defined as pneumonia, respiratory failure, or other pulmonary complications (including pneumonitis; pulmonary congestion; iatrogenic pulmonary embolism, infarction, or pneumothorax). Secondary outcomes focused on the components of pneumonia and respiratory failure. Results Of 30,026 patients receiving sugammadex, 22,856 were matched to 22,856 patients receiving neostigmine. Out of 45,712 patients studied, 1,892 (4.1%) were diagnosed with the composite primary outcome (3.5% sugammadex vs. 4.8% neostigmine). A total of 796 (1.7%) patients had pneumonia (1.3% vs. 2.2%), and 582 (1.3%) respiratory failure (0.8% vs. 1.7%). In multivariable analysis, sugammadex administration was associated with a 30% reduced risk of pulmonary complications (adjusted odds ratio, 0.70; 95% CI, 0.63 to 0.77), 47% reduced risk of pneumonia (adjusted odds ratio, 0.53; 95% CI, 0.44 to 0.62), and 55% reduced risk of respiratory failure (adjusted odds ratio, 0.45; 95% CI, 0.37 to 0.56), compared to neostigmine. Conclusions Among a generalizable cohort of adult patients undergoing inpatient surgery at U.S. hospitals, the use of sugammadex was associated with a clinically and statistically significant lower incidence of major pulmonary complications. Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New

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Section: Methodsmentioning

confidence: 99%

Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade and Postoperative Pulmonary Complications (STRONGER)

et al. 2020

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“…The criteria for selecting variables into the multivariable model were p-value of 0.1 and less while exclusion criteria was p = 0.05. The goodness of fit of the model was monitored by increase in the value of the log likelihood and p-values of the coefficients because available common standard statistical packages do not have diagnostic statistics for matched designs [ 30 ]. Item non-response was nil for most of the key variables and very minimal (<2%) where it existed.…”

Section: Methodsmentioning

confidence: 99%

Factors Associated with Injuries among Commercial Motorcyclists: Evidence from a Matched Case Control Study in Kampala City, Uganda

2016

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IntroductionRoad traffic injuries are the eighth leading cause of death globally and the most affected are young people aged 15–29. By 2030 road traffic deaths will become the fifth leading cause of death unless urgent action is taken. Motorcyclists are among the most vulnerable road users and in Uganda they contribute 41% of all road traffic injuries. This paper establishes factors associated with the injuries of commercial motorcycle riders also known as boda-boda riders in Kampala, Uganda’s capital city.MethodsThe study was matched case-control with a case being a boda-boda rider that was seen at one of the 5 major city hospitals with a road traffic injury while a control was a boda-boda rider that was at the parking stage where the case operated from before the injury. The sample size was 289 riders per arm and data collection took 7 months. A structured questionnaire was used to collect data on background and exposing factors. Being matched case-control data conditional logistic regression was used in the analysis.ResultsFactors independently associated with injury among motorcyclists were younger age group, being a current alcohol drinker (OR = 2.30, 95%CI: 1.19–4.45), lower engine capacity (<100cc)(OR = 5.03, 95%CI: 2.91–8.70), riding experience of less than 3 years, not changing a motorcycle in past 1 year (OR = 2.04, 95%CI: 1.19–3.52), riding for a longer time in a day (OR = 6.05, 95%CI: 2.58–14.18) and sharing a motorcycle (OR = 8.25, 95%CI:2.62–25.9). Other factors associated with injury were low level of knowledge of traffic rules, being stopped by police for checks on condition of motorcycle/license/insurance, working till late.RecommendationsMore road safety sensitization is required among riders to raise awareness against sharing motorcycles, working for a longer time and alcohol consumption. Police enforcement of drink-driving laws should include riders of commercial motorcycles. Investigate the validity of motorcycle riding licenses and test the riding competency of all who got licenses in last 3 years.

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“…Due to the lack of statistical software available to calculate diagnostic statistics for conditional logistic regression, model diagnostics were performed using standard logistic regression diagnostics. 31 …”

Section: Methodsmentioning

confidence: 99%

Emergency Department Utilization Among Assault-Injured Youth

Benedict¹,

Amanullah²,

Linakis³

et al. 2017

Pediatr Emer Care

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Objective Assault is a common cause of youth emergency department (ED) visits. Little is known about prior ED utilization patterns among assault-injured youth. This study’s objectives were to determine whether, and how, prior ED visit history distinguishes assault-injured youth from unintentionally injured youth. Methods A five-year retrospective, case-control study was conducted using a hospital-billing database. Youth ages 13 to 24 years presenting to the ED of an urban Level I Trauma center in 2011 with an E-code of physical assault-or weapon-related injuries were compared 1:1 to randomly assigned, age- and sex- matched controls with an E-code corresponding to unintentional injury. Bivariate, t-test, Wilcoxon rank sum tests, and conditional logistic regression were performed to determine how previous ED visits distinguished assault-injured youth from unintentionally injured youth. Results In 2011, 964 patients presented with assault-related injuries. Over the previous five years, assault-injured youth had a median of 1 prior ED visit (Interquartile range (IQR): 0 – 3); unintentionally injured youth had a median of zero prior ED visits (IQR: 0 – 2). Assault-injured youth had significantly higher median numbers of previous psychiatric and assault-related ED visits when compared to unintentionally injured youth. Youth with one previous psychiatric ED visit had a four-fold increased odds (AOR 4.05, 95% CI 2.41–6.83) of having a 2011 assault-related ED visit compared to unintentionally injured youth. Conclusion Assault-injured youth are more likely to have had prior ED use particularly for psychiatric illnesses and assault-related injury. Targeted youth violence screening may be appropriate for such patients.

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Nonparametric Diagnostic Test for Conditional Logistic Regression

Cited by 3 publications

References 14 publications

Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade and Postoperative Pulmonary Complications (STRONGER)

Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade and Postoperative Pulmonary Complications (STRONGER)

Factors Associated with Injuries among Commercial Motorcyclists: Evidence from a Matched Case Control Study in Kampala City, Uganda

Emergency Department Utilization Among Assault-Injured Youth

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