Nonpathogenic Simian Immunodeficiency Virus Infections

Klatt, Nichole R.; Silvestri, Guido; Hirsch, Vanessa M.

doi:10.1101/cshperspect.a007153

Cited by 62 publications

(51 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, it identifies another striking similarity between VNPs and naturally SIVsmm-infected SMs, who also experience a non-pathogenic, immunologically benign infection despite chronic virus replication [20]. Our observation that T CM and T SCM in VNPs harbor less HIV DNA as opposed to PPs is also consistent with another recent report suggesting that VNPs tend to have lower T cell activation than progressors in peripheral blood, yet higher T cell activation in the rectal mucosa, where a much higher proportion of CD4+ T cell have an effector phenotype [18].…”

Section: Discussionmentioning

confidence: 90%

Limited HIV Infection of Central Memory and Stem Cell Memory CD4+ T Cells Is Associated with Lack of Progression in Viremic Individuals

et al. 2014

View full text Add to dashboard Cite

A rare subset of HIV-infected individuals, designated viremic non-progressors (VNP), remain asymptomatic and maintain normal levels of CD4+ T-cells despite persistently high viremia. To identify mechanisms potentially responsible for the VNP phenotype, we compared VNPs (average >9 years of HIV infection) to HIV-infected individuals who have similar CD4+ T-cell counts and viral load, but who are likely to progress if left untreated (“putative progressors”, PP), thus avoiding the confounding effect of differences related to substantial CD4+ T cell depletion. We found that VNPs, compared to PPs, had preserved levels of CD4+ stem cell memory cells (TSCM (p<0.0001), which was associated with decreased HIV infection of these cells in VNPs (r = −0.649, p = 0.019). In addition, VNPs had decreased HIV infection in CD4+ central memory (TCM) cells (p = 0.035), and the total number of TCM cells was associated with increased proliferation of memory CD4+ T cells (r = 0.733, p = 0.01). Our results suggest that, in HIV-infected VNPs, decreased infection of CD4+ TCM and TSCM, cells are involved in preservation of CD4+ T cell homeostasis and lack of disease progression despite high viremia.

show abstract

Section: Discussionmentioning

confidence: 90%

Limited HIV Infection of Central Memory and Stem Cell Memory CD4+ T Cells Is Associated with Lack of Progression in Viremic Individuals

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Thus, our understanding of the evolutionary history of primate lentiviruses is still incomplete. To date, serological evidence of SIV infection has been reported for over 40 primate species, and molecular data have been obtained for most of these (also see Klatt et al 2011). The latter studies have shown that the great majority of primate species harbor a single "type" or "strain" of SIV.…”

Section: Primate Lentivirusesmentioning

confidence: 98%

Origins of HIV and the AIDS Pandemic

Sharp¹,

Hahn²

2011

Cold Spring Harbor Perspectives in Medicine

1,072

810

View full text Add to dashboard Cite

“…Nonhuman primates (NHP), whether naturally or experimentally infected with simian immunodeficiency viruses (SIVs), display phenotypic variation on multiple levels, including differences in relative susceptibility to infection, variability in both acute and long-term viral replication levels, differing rates of disease progression, and differences in degree of pathogenesis (see Klatt et al 2011;Lifson and Haigwood 2011). NHP populations, including both wild populations and captive-bred colonies, comprise genetically variable, outbred individuals, and it is reasonable to assume that variation in virological phenotypes reflects, in part, host genetic variation.…”

Section: Primate Geneticsmentioning

confidence: 99%