We compute the production of quark-antiquark pairs in high energy collisions between a small and a large projectile, as in proton-nucleus collisions, in the framework of the Color Glass Condensate. We derive a general expression for quark pair-production, which is not k ⊥ -factorizable. However, k ⊥ -factorization is recovered in the limit of large mass pairs or large quark-anti-quark momenta. Our results are amenable to a simple interpretation and suggest how multi-parton correlations at small x can be quantified in high-energy proton/deuteron-nucleus collisions.