Norditerpene furan glycosides from Tinospora cordifolia

Gangan, Vijay D.

doi:10.1016/0031-9422(95)00115-n

Cited by 33 publications

(20 citation statements)

References 3 publications

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“…A variety of constituents are present in TC plant belonging to different classes such as alkaloids, diterpenoid lactones, glycosides, steroids, sesquiterpenoid, phenolics, aliphatic compounds and polysaccharides. Water soluble isoquinoline alkaloids, namely, jatrorrhizine, palamatine, berberine, tembetarine, magnoflorine, choline, tinosporine, isocolumbine and hydrastine are present (Bisset & Nwaiwu, 1983;Gangan, Pradhan, Sipahimalani, & Banerji, 1994;Kumar, Verma, Pande, & Srivastava, 2000;Pachaly & Schneider, 1981;Padhya, 1986;Qudrat-I-Khuda, Khaleque, & Ray, 1964;Sarma, Khosa, & Sahai, 1995;Sarma, Padma, & Khosa, 1998). Since majority of the hypoglycemic activity of TC has been carried out on its aqueous extract, the present studies were undertaken to evaluate TC alkaloid, for their a-glucosidase inhibitory activity in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 94%

Magnoflorine from Tinospora cordifolia stem inhibits α-glucosidase and is antiglycemic in rats

Patel

Mishra

2012

Journal of Functional Foods

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A B S T R A C TAntidiabetic potential of Tinospora cordifolia stem is well proven. In the course of screening of useful a-glucosidase inhibitors, we prepared alkaloid fraction (AFTC) and isolated three isoquinoline alkaloids, namely, jatrorrhizine, palmatine and magnoflorine as active candidates for a-glucosidase inhibition. The enzyme kinetics was studied using sucrose and maltose as substrates. Michaelis-Menten constant (K m ) and maximal velocity (V max ) values were estimated. A significant decrease in V max and unaltered K m was observed in case of jatrorrhizine and palmatine (non-competitive inhibition). Magnoflorine was found to increase apparent K m and shown to be reversible, competitive inhibition. The IC 50 value as sucrase inhibitor was 36.25, 23.46 and 9.8 lg/mL for jatrorrhizine, palmatine and magnoflorine, respectively, and as maltase inhibitor was 22.05, 38.42 and 7.6 lg/mL for jatrorrhizine, palmatine and magnoflorine, respectively. In vivo studies were conducted on rats to determine oral glucose tolerance test (OGTT), using different substrates: glucose, sucrose and maltose. The increase in plasma glucose level was significantly suppressed (P < 0.01) by all the three alkaloids at 20 mg/kg b.w. Magnoflorine possessed the most potential activity as a-glucosidase inhibitor in vitro and in vivo.

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Section: Introductionmentioning

confidence: 94%

Magnoflorine from Tinospora cordifolia stem inhibits α-glucosidase and is antiglycemic in rats

Patel

Mishra

2012

Journal of Functional Foods

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“…Several low and high molecular weight constituents from the aqueous and alcoholic Tc stem extracts have been well characterized [8][9][10][11][12][13]. The aqueous extract of the Tc stem displayed a concentration dependent polyclonal mitogenic activity against murine spleen cells and lymph node cells [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

G1-4 A, an arabinogalactan polysaccharide from Tinospora cordifolia increases dendritic cell immunogenicity in a murine lymphoma model

Pandey

Shankar

Sainis

2012

International Immunopharmacology

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“…The major isolated compounds include the norditerpene furan glycosides cordiofolisides A, B, and C [21] the daucanetype sesquiterpenes tinocordifolin and tinocordifolioside [22,23]. In addition, syringin, cordiol, cordioside, and the phenylpropene disaccharides cordifoliosides A and B were identified as the active principles with anticomplement and immunomodulatory activities.…”

Section: A D Chougale Et Almentioning

confidence: 99%