Normal axonal ion channel function in large peripheral nerve fibers following chronic ciguatera sensitization

Vucic, Steve; Kiernan, Matthew C.

doi:10.1002/mus.20906

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…Obviously, the presentation of all the pollen at once and the visitation rate is sufficient for fruiting. This high efficiency of pollination has also been observed in many other plant species (Vaughton and Ramsey 2008). In Melampyrum roseum var.…”

Section: Discussionsupporting

confidence: 74%

Slow stamen movement in a perennial herb decreases male–male and male–female interference

Wang

et al. 2017

AoB PLANTS

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This study suggested that slow stamen movement in Lychnis cognata presents pollen gradually to pollinators, representing an adaptation to decrease interference between dehisced and dehiscing anthers and pistils that could promote pollen export and deposits. Adaptations that decrease both male-male sexual interference and male-female sexual interference should be recognized as important selective forces in floral evolution. This study also proposed that other selective pressures, including pollen dispensing mechanisms, pollen longevity, pollinator behavior and weather, might contribute to floral evolution.

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Section: Discussionsupporting

confidence: 74%

Slow stamen movement in a perennial herb decreases male–male and male–female interference

Wang

et al. 2017

AoB PLANTS

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“…The frequency of cases of so-called chronic ciguatera (i.e., chronic symptoms after acute exposure to CTX) has been estimated to be 5%–20% [ 88 , 89 ] but reached 34% in one study [ 90 ]. These symptoms persist intermittently without any particular triggering factor and/or reappear after the consumption of certain drinks or foods, especially alcohol but also peanuts, nonciguateric seafood, pork or poultry [ 64 , 66 , 91 ]. Occurring long after the incriminated meal, they make the diagnosis difficult, in particular for physicians unfamiliar with CFP.…”

Section: Clinical Features Of Ciguateramentioning

confidence: 99%

“…An interesting axonal excitability study was performed in two patients presenting with relapsing sensory disturbances many years after the acute phase of CFP [ 91 ]. The results obtained by stimulating the median nerve revealed no abnormalities of axonal Na v functions in both motor and sensory nerves.…”

Section: Pathophysiological Basis Of Ciguatera Neurological Disturmentioning

confidence: 99%

Neurological Disturbances of Ciguatera Poisoning: Clinical Features and Pathophysiological Basis

L’Hérondelle

Talagas

Mignen

et al. 2020

Cells

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Ciguatera fish poisoning (CFP), the most prevalent seafood poisoning worldwide, is caused by the consumption of tropical and subtropical fish contaminated with potent neurotoxins called ciguatoxins (CTXs). Ciguatera is a complex clinical syndrome in which peripheral neurological signs predominate in the acute phase of the intoxication but also persist or reoccur long afterward. Their recognition is of particular importance in establishing the diagnosis, which is clinically-based and can be a challenge for physicians unfamiliar with CFP. To date, no specific treatment exists. Physiopathologically, the primary targets of CTXs are well identified, as are the secondary events that may contribute to CFP symptomatology. This review describes the clinical features, focusing on the sensory disturbances, and then reports on the neuronal targets and effects of CTXs, as well as the neurophysiological and histological studies that have contributed to existing knowledge of CFP neuropathophysiology at the molecular, neurocellular and nerve levels.

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“…Mechanisms of neurotoxicity are diverse but include progressive axonal damage as well as acute modulation of ion channel function. Assessment of nerve excitability provides useful information about mechanisms of neurotoxicity in toxic neuropathy, with studies already completed in marine toxicology ( Kiernan et al, 2005a; Vucic and Kiernan, 2008 ) and chemotherapy‐induced neurotoxicity ( Krishnan et al, 2005c; 2006c; Kiernan and Krishnan, 2006 ).…”

Section: Toxic Neuropathymentioning

confidence: 99%

Assessment of nerve excitability in toxic and metabolic neuropathies

Krishnan

Lin

Park

et al. 2008

J Peripheral Nervous Sys

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Measurement of nerve excitability by threshold tracking provides complementary information to conventional nerve conduction studies and may be used to infer the activity of a variety of ion channels, energy-dependent pumps, and ion exchange processes activated during the process of impulse conduction. This review highlights recent clinical excitability studies that have suggested mechanisms for nerve involvement in a range of metabolic and toxic neuropathies. While clinical nerve excitability studies are still in their infancy, and it is too early to know whether they have diagnostic value, there is growing evidence of their utility to provide novel insights into the pathophysiological mechanisms involved in a variety of neuropathic disturbances.

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Normal axonal ion channel function in large peripheral nerve fibers following chronic ciguatera sensitization

Cited by 6 publications

References 10 publications

Slow stamen movement in a perennial herb decreases male–male and male–female interference

Slow stamen movement in a perennial herb decreases male–male and male–female interference

Neurological Disturbances of Ciguatera Poisoning: Clinical Features and Pathophysiological Basis

Assessment of nerve excitability in toxic and metabolic neuropathies

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