Nosocomial viral ventilator-associated pneumonia in the intensive care unit: a prospective cohort study

Daubin, Cédric; Vincent, Sophie; Vabret, Astrid; Cheyron, Damien du; Parienti, Jean‐Jacques; Ramakers, Michel; Freymuth, F.; Charbonneau, P.

doi:10.1007/s00134-005-2706-1

Cited by 63 publications

(54 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, HSV-2 was not detected in any of the patients. In comparison to previous reports that estimated lower prevalence of HHVs at the intensive care unit (ICU) (less than 5%) (37)(38)(39), there was a notably greater prevalence of HHVs at the PICU in our study.…”

Section: Discussioncontrasting

confidence: 99%

Prevalence of Human Herpes Viruses in Bronchoalveolar Lavage of Critically Ill Children Undergoing Mechanical Ventilation at a Pediatric Intensive Care Unit

Amanati

Karimi

Fahimzad

et al. 2018

Arch Pediatr Infect Dis

View full text Add to dashboard Cite

Background: Critically ill children at the intensive care unit frequently develop hospital-acquired pneumonia (HAP). Human herpes viruses (HHVs), primarily or by reactivation may cause bronchopneumonitis in mechanically ventilated patients. The exact prevalence and role of HHVs in morbidity and mortality of pediatric patients undergoing mechanical ventilation is unclear. The current study was conducted to evaluate the prevalence of 5 Herpes viruses by polymerase chain reaction (PCR) method in bronchoalveolar lavage (BAL) samples in critically ill children at a pediatric intensive care unit (PICU). Methods: Overall, 140 bronchoalveolar lavage samples from 83 mechanically ventilated cases were studied. Samples were taken via the mini-BAL technique. Samples were analyzed by qualitative PCR for detection of herpes simplex virus type 1 and 2 (HSV1/HSV2), human herpes virus type 6 and 7 (HHV6/HHV7), Ebstein-Barr virus (EBV), and cytomegalovirus (CMV).

show abstract

Section: Discussioncontrasting

confidence: 99%

Prevalence of Human Herpes Viruses in Bronchoalveolar Lavage of Critically Ill Children Undergoing Mechanical Ventilation at a Pediatric Intensive Care Unit

Amanati

Karimi

Fahimzad

et al. 2018

Arch Pediatr Infect Dis

View full text Add to dashboard Cite

show abstract

“…Third, nonbacterial causes of pneumonia. It has been seen recently that herpes simplex virus and cytomegalovirus could be the potential causes of VAP (38)(39)(40)(41). We did not search for viruses in our samples.…”

Section: Discussionmentioning

confidence: 57%

ICU-Acquired Pneumonia With or Without Etiologic Diagnosis

Giunta

Ferrer

Esperatti

et al. 2013

Critical Care Medicine

View full text Add to dashboard Cite

Although the possible influence of previous intubation in mortality of both groups is not completely discarded, negative microbiologic findings in clinically suspected ICU-acquired pneumonia are associated with less frequent previous intubation, shorter duration of antimicrobial treatment, and better survival. Future studies should corroborate the presence of pneumonia in patients with suspected ICU-acquired pneumonia and negative microbiology.

show abstract

“…However, data on viral nosocomial pneumonia are scarce, and the role of respiratory viruses as a cause of nosocomial pneumonia is probably limited. Daubin et al [36], in a prospective study on 139 mechanically ventilated patients, showed that only two out of 39 patients suspected of having developed VAP had a respiratory sample (tracheal aspirate) positive for respiratory viruses (one enterovirus and one influenza). Notably, in this study, 12 patients (31%) had a sample positive for HSV and one for cytomegalovirus [36].…”

Section: Respiratory Virusesmentioning

confidence: 99%

Viral infections in the ICU

Luyt

Combes

Nieszkowska

et al. 2008

Current Opinion in Critical Care

View full text Add to dashboard Cite

Respiratory viruses are responsible for 10% of community-acquired pneumonia cases but do not cause nosocomial pneumonia. Herpesviridae, mainly herpes simplex virus and cytomegalovirus, are commonly detected in the respiratory tract of nonimmunocompromised, mechanically ventilated patients. Although their detection usually reflects viral reactivation without lung parenchymal involvement, in a particular subset of patients, viral lung disease (bronchopneumonitis) occurs. This bronchopneumonitis seems to have a true impact on outcome, but only interventional studies will be able to determine its real impact. Whether other viruses, such as mimivirus, are responsible for nosocomial pneumonia in mechanically ventilated patients requires additional studies.

show abstract

Nosocomial viral ventilator-associated pneumonia in the intensive care unit: a prospective cohort study

Abstract: We found a high incidence of HSV-1 infection in VAP patients; however, nosocomial viral VAP is likely to be rare in ICU, as assessed by the absence of respiratory virus-induced VAP identified in this prospective cohort study.

Cited by 63 publications

References 33 publications

Prevalence of Human Herpes Viruses in Bronchoalveolar Lavage of Critically Ill Children Undergoing Mechanical Ventilation at a Pediatric Intensive Care Unit

Prevalence of Human Herpes Viruses in Bronchoalveolar Lavage of Critically Ill Children Undergoing Mechanical Ventilation at a Pediatric Intensive Care Unit

ICU-Acquired Pneumonia With or Without Etiologic Diagnosis

Viral infections in the ICU

Contact Info

Product

Resources

About