Notch signaling in gastrointestinal tract (Review)

Katoh, Masuko; Katoh, Masaru

doi:10.3892/ijo.30.1.247

Cited by 140 publications

(164 citation statements)

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“…Notch receptor-mediated induction of HES2 by membrane-bound ligand Dll4 has been reported (40), and several reports indicate an active role of HES2 in proliferative processes, such as spontaneous malignant transformation of stem cells (41) and various tumors, e.g. of the gastrointestinal tract (42) and Ras-transformed astrocytes (43). YB-1 knock-out mice exhibit neural tube defects with abnormal patterns of cell proliferation within the neuroepithelium (44).…”

Section: Discussionmentioning

confidence: 99%

YB-1 Acts as a Ligand for Notch-3 Receptors and Modulates Receptor Activation

Rauen

Raffetseder

Frye

et al. 2009

Journal of Biological Chemistry

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Y-box (YB) protein-1 is secreted by mesangial and immune cells after cytokine challenge, but extracellular functions are unknown. Here, we demonstrate that extracellular YB-1 associates with outer cell membrane components and interacts with extracellular Notch-3 receptor domains. The interaction appears to be specific for Notch-3, as YB-1-green fluorescent protein binds to the extracellular domains and full-length forms of Notch-3 but not to Notch-1. YB-1-green fluorescent protein and Notch-3 proteins co-localize at cell membranes, and extracellular YB-1 activates Notch-3 signaling, resulting in nuclear translocation of the Notch-3 intracellular domain and up-regulation of Notch target genes. The YB-1/Notch-3 interaction may be of particular relevance for inflammatory mesangioproliferative disease, as both proteins co-localize in an experimental nephritis model and receptor activation temporally and spatially correlates with YB-1 expression.

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Section: Discussionmentioning

confidence: 99%

YB-1 Acts as a Ligand for Notch-3 Receptors and Modulates Receptor Activation

Rauen

Raffetseder

Frye

et al. 2009

Journal of Biological Chemistry

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“…Mammals consist of four Notch genes and each one encodes a single-pass transmembrane receptor (Notch 1-4). The interaction between Notch receptors and their ligands (Jagged 1 and 2 and Delta-like 1, 3 and 4) results in proteolytic cleavage of Notch by a γ-secretase, which releases the Notch intracellular domain (NICD) from the plasma membrane, initiating a subsequent nuclear forms a complex with one of three transcriptional regulators, including CSL [collectively referring to C-promoter binding factor (CBF)-1, Suppressor of Hairless in Drosophila, and Lag-1 in Caenorhabditis elegans also known as recombination signal-binding protein Jκ(RBP-Jκ)], mastermind (MAML)-1 and p300/CBP, followed by transcriptional activation of a set of target genes, including the hairy enhancer-of-split (Hes) gene family (Iso et al, 2003;Katoh and Katoh, 2007). Since Hes-1 is a transcriptional repressor, Notch signaling negatively regulates the Krüppel-like factor 4 (KLF4) through its activation of Hes-1 expression (Ghaleb et al, 2008).…”

Section: Notch Signaling and Colon Cancermentioning

confidence: 99%

Dietary Non-nutritive Factors in Targeting of Regulatory Molecules in Colorectal Cancer: An Update

Pandurangan

Esa²

2013

Asian Pacific Journal of Cancer Prevention

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Colorectal cancer (CRC), a complex multi-step process involving progressive disruption of homeostatic mechanisms controlling intestinal epithelial proliferation/inflammation, differentiation, and programmed cell death, is the third most common malignant neoplasm worldwide. A number of promising targets such as inducible nitric acid (iNOS), cyclooxygenase (COX)-2, NF-E2-related factor 2 (Nrf2), Wnt/β-catenin, Notch and apoptotic signaling have been identified by researchers as useful targets to prevent or therapeutically inhibit colon cancer development. In this review article, we aimed to explore the current targets available to eliminate colon cancer with an update of dietary and non-nutritional compounds that could be of potential use for interaction with regulatory molecules to prevent CRC.

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“…Notch signalling is known as an evolutionarily conserved mechanism involved in cell proliferation, differentiation and apoptosis (Katoh and Katoh, 2007;Hansson et al, 2004). Nowadays, it has been studied as an important factor in multiple contexts such as organ development (Hansson et al, 2004), tissue regeneration (Lovschall et al, 2005) and carcinogenesis (Liao et al, 2007;Maliekal et al, 2008;Talora et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays, it has been studied as an important factor in multiple contexts such as organ development (Hansson et al, 2004), tissue regeneration (Lovschall et al, 2005) and carcinogenesis (Liao et al, 2007;Maliekal et al, 2008;Talora et al, 2008). Briefly, it serves a fundamental role in many cell fate decisions, maintaining the balance between cell differentiation and proliferation (Katoh and Katoh, 2007).…”

Section: Introductionmentioning

confidence: 99%