Note: A gel based imaging technique of the iridocorneal angle for evaluation of angle-closure glaucoma

Abstract

Noninvasive medical imaging techniques have high potential in the field of ocular imaging research. Angle closure glaucoma is a major disease causing blindness and a possible way of detection is the examination of the anterior chamber angle in eyes. Here, a simple optical method for the evaluation of angle-closure glaucoma is proposed and illustrated. The light propagation from the region associated with the iridocorneal angle to the exterior of eye is considered analytically. The design of the gel assisted probe prototype is carried out and the imaging of iridocorneal angle is performed on an eye model.

Preclinical imaging of iridocorneal angle and fundus using a modified integrated flexible handheld probe

“…The phenomenon of total internal reflection (TIR) has to be taken into account when considering light transmission from the iridocorneal angle region, through the cornea, to the outside medium. 30 Under normal conditions, light from the iridocorneal angle region is incident onto the tear-air interface at an angle smaller than the critical angle, and hence all of it will be reflected. A schematic illustration of light transmission from iridocorneal angle to air is shown in Fig.…”

Fluorescence Resonance Energy Transfer (FRET)-Based ThT Free Sensing of Beta-Amyloid Fibrillation by Carbon Dot-Ag Composites

“…Imaging techniques are highly significant in various medical applications 15,16 . Brain imaging and study of the concentration of proteins in cerebrospinal fluid and blood using biomarkers are performed normally to identify AD [17][18][19][20][21] .…”

Integrated flexible handheld probe for imaging and evaluation of iridocorneal angle

“…The probe can be attached to a slit lamp, providing the flexibility to be used by a nontechnical person. 25 In this context, we propose a miniaturized integrated chargecoupled diode (CCD) camera and light-emitting diode (LED) light source-based probe system, which enables evaluation of the iridocorneal region inside the eye. Full details of the probe configuration and methodology are given in the following sections.…”