a b s t r a c tWe study a multivariate ultrastructural measurement error (MUME) model with more than one response variable. This model is a synthesis of multivariate functional and structural models. Three consistent estimators of regression coefficients, satisfying the exact linear restrictions have been proposed. Their asymptotic distributions are derived under the assumption of a non-normal measurement error and random error components. A simulation study is carried out to investigate the small sample properties of the estimators. The effect of departure from normality of the measurement errors on the estimators is assessed.