Novel Active Constituents of Momordica Charantia L.

Zhang, Y.; Cui, Jiucheng; Cao, Jian; Pan, H.; Zhao, Yuanchen

doi:10.1055/s-2009-1216432

Cited by 4 publications

(4 citation statements)

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“…[61]. This extract also showed the presence of two anticancer compounds namely Bluemenol A and xestoaminol C [62, 63].…”

Section: Resultsmentioning

confidence: 99%

Biological activities and metabolic profile of endophyticBacillus haynesiifromMomordica charantia

Sharma,

Agarwal,

Bhardwaj

et al. 2024

Preprint

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Endophytes share a complex intimate relationship due to which they are capable of synthesizing metabolites that are either similar or derivative of host bioactive compounds. Such endophytes especially from medicinal plants can be prospected for commercial-scale production of the therapeutic compound. Thus, the study evaluates the antioxidant and anti-inflammatory potential of Momordica charantia fruit endophyte Bacillus haynesii R2MCFF61, and determines its metabolite profile through LC-Q-TOF-MS for the bioactive compounds produced. B. haynesii R2MCFF61 showed significant antioxidant and anti-inflammatory potential with increased DPPH scavenging activity in the standard compound and inhibition of protein denaturation respectively. The metabolic profile of this endophyte showed 23 compounds, mostly consisting of metabolites from lipid, phenylpropanoid and triterpenoid pathways. B. haynesii R2MCFF61 showed production of cucurbitane-triterpenoids namely Momordicoside K, 19-dimethoxycucurbita-5(10),6,22(E),24-tetraen-3β-ol and 23(E)-7β-methoxycucurbita-5,23,25-trien-3β-ol. These compounds are mainly produced by M. charantia fruit and their production by its endophyte is reported for the first time. Thus, these results indicate the promising therapeutic potential of B. haynesii R2MCFF61 which can be utilized as a low-cost sustainable source of these bioactive compounds.

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“…[61]. This extract also showed the presence of two anticancer compounds namely Bluemenol A and xestoaminol C [62, 63].…”

Section: Resultsmentioning

confidence: 99%

Biological activities and metabolic profile of endophyticBacillus haynesiifromMomordica charantia

Sharma,

Agarwal,

Bhardwaj

et al. 2024

Preprint

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show abstract

“…Finally, they also estimated the upper and lower bounds of the blow-up time by some differential inequality techniques. For more recent references on Kirchhoff-type problems, we refer to [6,7,8,12,13,14,26,27,28,32,33,35,36,37,39,41].…”

Section: Introductionmentioning

confidence: 99%

Global solutions and blow-up for a Kirchhoff-type problem on a geodesic ball of the Poincare ball model

Ding¹,

Zhou²

2022

ejde

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This article concerns a Kirchhoff-type parabolic problem on a geodesic ball of hyperbolic space. Firstly, we obtain conditions for finite time blow-up, and for the existence of global solutions for \(J(u_0)\leq d\), where \(J(u_0)\) denotes the initial energy and d denotes the depth of the potential well. Secondly, we estimate the upper and lower bounds of the blow-up time. In addition, we derive the growth rate of the blow-up solution and the decay rate of the global solution. Thirdly, we establish a new finite time blow-up condition which is independent of d and prove that the solution can blow up in finite time with arbitrary high initial energy, by using this blow-up condition. Finally, we present some equivalent conditions for the solution existing globally or blowing up in finite time.

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“…Previously, three cucurbitane-type triterpenoids, charantagenins A, B, and C, were isolated from the alcohol extract of the dried fruit of Chinese M. charantia, which is commonly called "charantagenins". 10 The continued study on the triterpenoid constituents of the alcohol extract of M. charantia fruit now lead to the isolation of two new cucurbitane-type triterpenoids, named charantagenins D (1) and E (2) and one new sterol, 7-oxostigmasta-5,25-diene-3-O-β-D-glucopyranoside (3) together with eight known compounds [charantoside VI (4) 23 kuguaglycoside C (5), 24 momordicoside K (6), 25 goyaglycoside d ( 7), 26 goyaglycoside b (8) 26 stigmasta-7,25(27)-dien-3β-ol (9), 27 charantadiol A (10), 28 and 3β,25-dihydroxy-5β,19epoxycucurbita-6(23E)-diene (11) 29 ] (Figure 1). Besides the isolation and structure elucidation of the new compounds, the cytotoxic effects of the compounds (1−3, 5−7, 9−11) against three cancer cell lines (A549, U87, and Hep3B) were also evaluated using the MTT assay in the present study.…”

Section: ■ Introductionmentioning

confidence: 99%

Structures of New Triterpenoids and Cytotoxicity Activities of the Isolated Major Compounds from the Fruit of Momordica charantia L.

Wang

Sun

Cao

et al. 2012

J. Agric. Food Chem.

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Two new cucurbitane-type triterpene glycosides, charantagenins D (1) and E (2), and one new sterol, 7-oxo-stigmasta-5,25-diene-3-O-β-d-glucopyranoside (3), were isolated from the fruit of Momordica charantia L. together with another eight known compounds. Their structures were determined on the basis of spectral analysis. Cytotoxicity activities of the isolated major compounds were evaluated against lung cancer cell line A549, glioblastoma cell line U87, and hepatoma carcinoma cell line Hep3B by using a 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) in vitro assay. Results showed compounds 1 and 7 (goyaglycoside d) with an -OMe substituent group in the side chain exhibited significant cytotoxic activities against cancer cells. Impressively, the IC(50) values of the new compound 1 to A549, U87, and Hep3B were 1.07, 1.08, and 14.01 μmol/L, respectively, which were much lower than those of other tested compounds.

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Novel Active Constituents of Momordica Charantia L.

Cited by 4 publications

References 0 publications

Biological activities and metabolic profile of endophyticBacillus haynesiifromMomordica charantia

Biological activities and metabolic profile of endophyticBacillus haynesiifromMomordica charantia

Global solutions and blow-up for a Kirchhoff-type problem on a geodesic ball of the Poincare ball model

Structures of New Triterpenoids and Cytotoxicity Activities of the Isolated Major Compounds from the Fruit of Momordica charantia L.

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