Novel Antiplatelet Constituents from Formosan Moraceous Plants

Lin, Chun‐Nan; Lu, Chai-Ming; Lin, Hsien-Cheng; Fang, Song-Chwan; Shieh, Bor‐Jinn; Hsu, Mei‐Feng; Wang, Jin-Pyang; Ko, Feng‐Nien; Teng, Che-Ming

doi:10.1021/np960376j

Cited by 80 publications

(40 citation statements)

References 8 publications

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“…The following report also demonstrated that several preny- lated flavonoids including kuwanons and sanggenon D were COX inhibitors (27). Several prenylated flavonoids such as cycloheterophyllin, broussochalcone A, broussoaurone A, and broussoflavonol F inhibited platelet aggregation and inhibited COX from ram seminal vesicle (IC 50 of 17.5 -26.1 mg/ ml) (28). Recently, some other prenylated flavonoids including kuraridin, kurarinone, and sophoraflavanone G were found to possess potent COX-1 inhibitory activity from bovine platelet homogenate at micromolar concentrations (IC 50 = 0.1 -1 mM), being comparable to indomethacin (IC 50 = 0.9 m M) (29).…”

Section: Cellular Action Mechanismsmentioning

confidence: 65%

Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms

et al. 2004

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Abstract. Plant flavonoids show anti-inflammatory activity in vitro and in vivo. Although not fully understood, several action mechanisms are proposed to explain in vivo anti-inflammatory action. One of the important mechanisms is an inhibition of eicosanoid generating enzymes including phospholipase A 2 , cyclooxygenases, and lipoxygenases, thereby reducing the concentrations of prostanoids and leukotrienes. Recent studies have also shown that certain flavonoids, especially flavone derivatives, express their anti-inflammatory activity at least in part by modulation of proinflammatory gene expression such as cyclooxygenase-2, inducible nitric oxide synthase, and several pivotal cytokines. Due to these unique action mechanisms and significant in vivo activity, flavonoids are considered to be reasonable candidates for new anti-inflammatory drugs. To clearly establish the therapeutic value in inflammatory disorders, in vivo anti-inflammatory activity, and action mechanism of varieties of flavonoids need to be further elucidated. This review summarizes the effect of flavonoids on eicosanoid and nitric oxide generating enzymes and the effect on expression of proinflammatory genes. In vivo anti-inflammatory activity is also discussed. As natural modulators of proinflammatory gene expression, certain flavonoids have a potential for new anti-inflammatory agents.

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Section: Cellular Action Mechanismsmentioning

confidence: 65%

Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms

et al. 2004

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“…Several previous studies reported the characterization of prenylflavonoids from A. heterophyllus [7 -9] and their anti-inflammatory [10], antioxidant [11,12], melanin-biosynthesis inhibitory [13], and antiplatelet [14] activities. In addition, extract of the wood of A. heterophyllus was reported to inhibit tyrosinase activity [15,16].…”

Section: Introductionmentioning

confidence: 99%

Isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as antibrowning agent

Zheng

Cheng

et al. 2008

Molecular Nutrition Food Res

118

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A new furanoflavone, 7-(2,4-dihydroxyphenyl)-4-hydroxy-2-(2-hydroxy propan-2-yl)-2, 3-dihydrofuro(3, 2-g)chromen-5-one (artocarpfuranol, 1), together with 14 known compounds, dihydromorin (2), steppogenin (3), norartocarpetin (4), artocarpanone (5), artocarpesin (6), artocarpin (7), cycloartocarpin (8), cycloartocarpesin (9), artocarpetin (10), brosimone I (11), cudraflavone B (12), carpachromene (13), isoartocarpesin (14), and cyanomaclurin (15) were isolated from the wood of Artocarpus heterophyllus. Their structures were identified by interpretation of MS,( 1)H-NMR,( 13)C-NMR, HMQC, and HMBC spectroscopic data. Among them, compounds 1-6 and 14 showed strong mushroom tyrosinase inhibitory activity with IC(50) values lower than 50 microM, more potent than kojic acid (IC(50) = 71.6 microM), a well-known tyrosinase inhibitor. In addition, extract of A. heterophyllus was evaluated for its antibrowning effect on fresh-cut apple slices. It was discovered that fresh-cut apple slices treated by dipping in solution of 0.03 or 0.05% of A. heterophyllus extract with 0.5% ascorbic acid did not undergo any substantial browning reaction after storage at room temperature for 24 h. The antibrowning effect was significantly better than samples treated with the extract (0.03 or 0.05%) or ascorbic acid (0.5%) alone. The results provide preliminary evidence supporting the potential of this natural extract as antibrowning agent in food systems.

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“…In addition, artocarpin (2) also showed antioxidant activities by reducing the level of reactive oxygen species and lipid peroxidation, and exhibited anti-inflammatory activity by decreasing the levels of pro-inflammatory cytokines, such as tumor necrosis factor a and interleukin 1b (Lee et al, 2013) and inhibited lipopolysaccharide-induced nitric oxide (NO) production (Han et al, 2006). In addition, it also possessed some antiplatelet activity (Lin et al, 1996). Cyanomaclurin (4) inhibited mushroom tyrosinase activity with an IC 50 value of 68.7 mM (Zheng et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

“…A variety of flavonoids and prenylflavonoids have been isolated from this plant (Chung et al, 1995;Lin et al, 1995). Their biological effects have also been reported, including anti-inflammatory (Wei et al, 2005) (Zheng et al, 2008), cytotoxicity (Arung et al, 2010), antiplatelet (Lin et al, 1996), and antibacterial activities .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial assay-guided isolation of active compounds fromArtocarpus heterophyllusheartwoods

Septama¹,

Panichayupakaranant²

2015

Pharmaceutical Biology

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Context: Preparations from Artocarpus heterophyllus Lam. (Moraceae) heartwoods are used in the traditional folk medicine for the treatment of inflammation, malarial fever, and to prevent bacterial and fungal infections. Objective: The objective of this study was to isolate pure antibacterial compounds from A. heterophyllus heartwoods. Materials and methods: The dried and powdered A. heterophyllus heartwoods were successively extracted with the following solvents: hexane, ethyl acetate, and methanol. Each of the extracts was screened for their antibacterial activities using a disc diffusion method (10 mg/disc). Their minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) were determined using a broth microdilution method. The extract that showed the strongest antibacterial activities was fractionated to isolate the active compounds by an antibacterial assay-guided isolation process. Results and discussion: The ethyl acetate extract exhibited the strongest antibacterial activities against Streptococcus mutans, S. pyogenes, and Bacillus subtilis with MIC values of 78, 39, and 9.8 mg/mL, respectively. Based on an antibacterial assay-guided isolation, four antibacterial compounds: cycloartocarpin (1), artocarpin (2), artocarpanone (3), and cyanomaclurin (4) were purified. Among these isolated compounds, artocarpin exhibited the strongest antibacterial activity against Gram-positive bacteria, including S. mutans, S. pyogenes, B. subtilis, Staphylococcus aureus, and S. epidermidis with MICs of 4. 4, 4.4, 17.8, 8.9, and 8.9 mM, respectively, and MBCs of 8.9, 8.9, 17.8, 8.9, and 8.9 mM, respectively, while artocarpanone showed the strongest activity against Escherichia coli, a Gram-negative bacteria with MIC and MBC values of 12.9 and 25.8 mM, respectively. Only artocarpin showed inhibitory activity against Pseudomonas aeruginosa with an MIC of 286.4 mM.

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Novel Antiplatelet Constituents from Formosan Moraceous Plants

Cited by 80 publications

References 8 publications

Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms

Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms

Isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as antibrowning agent

Antibacterial assay-guided isolation of active compounds fromArtocarpus heterophyllusheartwoods

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