Novel biosynthesized gold nanoparticles as anti-cancer agents against breast cancer: Synthesis, biological evaluation, molecular modelling studies

Vemuri, Satish Kumar; Banala, Rajkiran Reddy; Mukherjee, Sudip; Purushotham, Uppula; Gpv, Subbaiah; Reddy, A V Gurava; Malarvilli, T

doi:10.1016/j.msec.2019.01.123

Cited by 97 publications

(48 citation statements)

References 37 publications

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“…Green synthesized of AuNPs (10 -42 nm) can induce the apoptosis activating the caspase-3 and 9 in human cervical cancer cells (Baharara et al, 2016) and the citrate-coated AuNPs (8 nm) promoted apoptosis eliciting BAX translocation and cytochrome c release in human liver (HL7702) cells (Gao et al, 2011). In agreement with literature findings (Sun et al, 2018;Vemuri et al, 2019), Au@PT cytotoxic effects elicited significant changes in survival and proliferation (AKT/PI3K and ERK pathways, respectively) as well as apoptotic process (pro-apoptotic BAX, anti-apoptotic BCL-xL, respectively) (Figure 5B). AKT and ERK activation levels were significantly reduced in the treatment with 2.5Au@PT and 5Au@PT than with control (Figures 5Ba-c), with a slight decrease after the incubation with 5Au@PT.…”

Section: Her Targeting: Evaluation Of Morphology Viability and Intrasupporting

confidence: 83%

“…Chattopadhyay et al (2010) showed that Trastuzumab-PEG-AuNPs (30 nm) in combination with 300 kVp X-rays enhanced DNA double strand breaks (DSBs) in SKBR-3 cells. Mechanistic studies performed by Vemuri et al (2019) revealed that the functionalization of naturally derived phytochemicals, such as Quercetin and Paclitaxel, to AuNPs were significantly effective in inhibiting cell proliferation, apoptosis, angiogenesis, colony formation and spheroid formation. AuNPs principally trigger apoptosis through intrinsic pathways, including mitochondria-and ER-related pathways.…”

Section: Her Targeting: Evaluation Of Morphology Viability and Intramentioning

confidence: 99%

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Extra-Small Gold Nanospheres Decorated With a Thiol Functionalized Biodegradable and Biocompatible Linear Polyamidoamine as Nanovectors of Anticancer Molecules

Bloise

Massironi

Pina

et al. 2020

Front. Bioeng. Biotechnol.

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Section: Her Targeting: Evaluation Of Morphology Viability and Intrasupporting

confidence: 83%

Section: Her Targeting: Evaluation Of Morphology Viability and Intramentioning

confidence: 99%

Extra-Small Gold Nanospheres Decorated With a Thiol Functionalized Biodegradable and Biocompatible Linear Polyamidoamine as Nanovectors of Anticancer Molecules

Bloise

Massironi

Pina

et al. 2020

Front. Bioeng. Biotechnol.

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“…The human embryonic kidney 293T (HEK293T) cell line is used as a normal human cell line in various biological experiments (Chen et al, 2016;Vemuri et al, 2019). In this study, we investigated the in vitro cytotoxic effect of styryllactones (concentration ranging from 0 and 100 mM) against HEK293T cells (Figure 4).…”

Section: Cytotoxic Effect Of Styryllactones Against the Human Normal mentioning

confidence: 99%

Hydroxypropyl-β-Cyclodextrin Complexes of Styryllactones Enhance the Anti-Tumor Effect in SW1116 Cell Line

Chen

et al. 2020

Front. Pharmacol.

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Styryllactones, a class of compounds obtained from the genus Goniothalamus (Annonaceae), have demonstrated in vitro antitumor activity. However, the aqueous solubility of these compounds is poor. In this study, we identified the absolute configurations of the previously isolated compounds, which were first isolated in our laboratory, by single-crystal X-ray diffraction analysis using Cu Ka radiation. Subsequently, the antitumor activities of the compounds were evaluated by 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide staining in four tumor cell lines. The induced apoptosis activity of leiocarpin E-7ʹ-Monoacetate was studied by an annexin V fluorescein isothiocyanate/propidium iodide double-staining experiment, and the caspase activity was tested in the SW1116 cell line. The results demonstrated that the antitumor activities of cheliensisin A and goniodiol-7-monoacetate were limited by their poor water solubility. To address this issue, hydroxypropyl-b-cyclodextrin (HP-b-CD) complexes of the compounds were synthesized by the saturated aqueous method. The complexes were then analyzed using a differential scanning calorimeter. The IC 50 of cheliensisin A was reduced by 45% and 58% against SW1116 and SMMC-7721 cell lines, respectively. Similarly, the IC 50 of goniodiol-7-monoacetate was reduced by 55% and 34% against the two tumor cell lines, respectively. To further evaluate whether the styryllactones and complexes possessed selectivity against cancer cell lines and normal cell lines, toxicity against human normal cell line (HEK293T) was evaluated. The results demonstrated that the HP-b-CD complexes displayed more cytotoxicity than the respective pristine compounds against the HEK293T cell line. However, there existed a therapeutic window when the complexes were applied against cancer cell lines. In summary, the synthesis of several styryllactone compounds complexed with HP-b-CD was reported for the first time. These complexes could significantly enhance the cytotoxic effects of styryllactone compounds.

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“…Compared with free curcumin, Cur-AuNPs showed significantly increased cytotoxicity to colon and breast cancer cells. The conjugated nanoparticles showed no toxicity to normal kidney cells, exhibiting excellent biocompatibility [ 285 , 286 ]. Compared with other nanoparticles, gold nanoparticles are composed of a small number of atoms, and fluoresce under visible light (550 nm) irradiation.…”

Section: Nanoformulations For Loading and Delivery Of Polyphenolsmentioning

confidence: 99%

Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

et al. 2020

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Polyphenols are micronutrients that are widely present in human daily diets. Numerous studies have demonstrated their potential as antioxidants and anti-inflammatory agents, and for cancer prevention, heart protection and the treatment of neurodegenerative diseases. However, due to their vulnerability to environmental conditions and low bioavailability, their application in the food and medical fields is greatly limited. Nanoformulations, as excellent drug delivery systems, can overcome these limitations and maximize the pharmacological effects of polyphenols. In this review, we summarize the biological activities of polyphenols, together with systems for their delivery, including phospholipid complexes, lipid-based nanoparticles, protein-based nanoparticles, niosomes, polymers, micelles, emulsions and metal nanoparticles. The application of polyphenol nanoparticles in food and medicine is also discussed. Although loading into nanoparticles solves the main limitation to application of polyphenolic compounds, there are some concerns about their toxicological safety after entry into the human body. It is therefore necessary to conduct toxicity studies and residue analysis on the carrier.

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Novel biosynthesized gold nanoparticles as anti-cancer agents against breast cancer: Synthesis, biological evaluation, molecular modelling studies

Cited by 97 publications

References 37 publications

Extra-Small Gold Nanospheres Decorated With a Thiol Functionalized Biodegradable and Biocompatible Linear Polyamidoamine as Nanovectors of Anticancer Molecules

Extra-Small Gold Nanospheres Decorated With a Thiol Functionalized Biodegradable and Biocompatible Linear Polyamidoamine as Nanovectors of Anticancer Molecules

Hydroxypropyl-β-Cyclodextrin Complexes of Styryllactones Enhance the Anti-Tumor Effect in SW1116 Cell Line

Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

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