Novel Bletilla striata polysaccharide microneedles: Fabrication, characterization, and in vitro transcutaneous drug delivery

Hu, Lingli; Liao, Zhencheng; Hu, Qi-Qi; Maffucci, Katherine G.; Qu, Yan

doi:10.1016/j.ijbiomac.2018.05.097

Cited by 64 publications

(28 citation statements)

References 41 publications

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“…The BSP has good pharmacological activities, such as promoting wound healing, antibacterial, antitumor, antifibrotic, and so on [13, 14]. Simultaneously, the BSP has great potential and application prospects in biological delivery systems, wound dressings, and other biomaterials because of its great biodegradability and biocompatibility [15–17]. In our previous study, the BSP has been found to play a nontrivial role in promoting oral ulcer healing as a component in buccoadhesive wafers [11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Polysaccharides from Bletilla striata on the Healing of Dermal Wounds in Mice

Zhang

Chen

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Bletilla striata has been largely used in traditional folk medicine in China as a wound healing agent and to treat gastritis and several other health problems. Some studies have shown that plant polysaccharides may have the ability to promote wound healing. The aim of this work was to evaluate the wound healing activity of the polysaccharide extracted from Bletilla striata. Firstly, a Bletilla striata polysaccharide was extracted by water extraction and alcohol precipitation and characterized by Fourier transform infrared spectroscopy. The Bletilla striata polysaccharide was then tested for cell migration and proliferation using the mouse fibroblast cell line. Then, the Bletilla striata hydrogel was fabricated for acute wound health care of the mouse full-thickness excision. The results showed that the BSP enhanced the proliferation and migration of L929 cells. The superior wound healing capacity of the BSP hydrogel was demonstrated that it significantly accelerated the wound healing process in vivo in full-thickness skin defect wounded models. Compared to the saline group, the BSP hydrogel could accelerate wound healing and promote re-epithelialization and collagen deposition by means of TGF-β/Smad signal pathway activation. Taken together, BSP hydrogel would be a useful pharmaceutic candidate for acute cutaneous wound health care.

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Section: Introductionmentioning

confidence: 99%

Effect of Polysaccharides from Bletilla striata on the Healing of Dermal Wounds in Mice

Zhang

Chen

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Confocal laser scanning microscopy signified the dissolution of the microneedle and the release of molecules into the skin. Thus, this study has highlighted the prospect of novel polysaccharides in tailoring dissolving microneedles [146]. Panax Noto ginseng is another herbal-based polysaccharide investigated for the preparation of a dissolving microneedle for transdermal drug delivery [147].…”

Section: Bletilla Striata (Bs)-based Microneedlementioning

confidence: 99%

Microneedle-Based Natural Polysaccharide for Drug Delivery Systems (DDS): Progress and Challenges

et al. 2022

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In this focused progress review, the most widely accepted methods of transdermal drug delivery are hypodermic needles, transdermal patches and topical creams. However, microneedles (MNs) (or microneedle arrays) are low-invasive 3D biomedical constructs that bypass the skin barrier and produce systemic and localized pharmacological effects. In the past, biomaterials such as carbohydrates, due to their physicochemical properties, have been extensively used to manufacture microneedles (MNs). Due to their wide range of functional groups, carbohydrates enable the design and development of tunable properties and functionalities. In recent years, numerous microneedle products have emerged on the market, although much research needs to be undertaken to overcome the various challenges before the successful introduction of microneedles into the market. As a result, carbohydrate-based microarrays have a high potential to achieve a future step in sensing, drug delivery, and biologics restitution. In this review, a comprehensive overview of carbohydrates such as hyaluronic acid, chitin, chitosan, chondroitin sulfate, cellulose and starch is discussed systematically. It also discusses the various drug delivery strategies and mechanical properties of biomaterial-based MNs, the progress made so far in the clinical translation of carbohydrate-based MNs, and the promotional opportunities for their commercialization. In conclusion, the article summarizes the future perspectives of carbohydrate-based MNs, which are considered as the new class of topical drug delivery systems.

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“…It is probably shattered and left as biohazardous sharp waste in the skin. A dissolving MNs made of BSP [ 94 ] breached the skin barrier of the stratum corneum painlessly, enhanced skin permeability and thereby improved transdermal drug delivery effect. After being inserted into the skin, the dissolving MNs gradually dissolved in the interstitial fluid, without sharps waste.…”

Section: Promoting Drug Absorption and Crossing Biologic Barriersmentioning

confidence: 99%

A review on the applications of Traditional Chinese medicine polysaccharides in drug delivery systems

Wang

Xiong

et al. 2022

Chin Med

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Traditional Chinese medicine polysaccharides (TCMPs) are plentiful and renewable resources with properties such as biocompatibility, hydrophilicity, biodegradability, and low cytotoxicity. Because the polysaccharide molecular chain contains a variety of active groups, different polysaccharide derivatives can be easily produced through chemical modification. They have been increasingly used in drug delivery systems (DDS). However, the potential of polysaccharides is usually ignored due to their structural complexity, poor stability or ambiguity of mechanisms of actions. This review summarized the applications of TCMPs in DDS around four main aspects. The general characteristics of TCMPs as drug delivery carriers, as well as the relationships between structure and function of them were summarized. Meanwhile, the direction of preparing multifunctional drug delivery materials with synergistic effect by using TCMPs was discussed. This review aims to become a reference for further research of TCMPs and their derivatives, especially applications of them as carriers in pharmaceutical preparation industry.

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Novel Bletilla striata polysaccharide microneedles: Fabrication, characterization, and in vitro transcutaneous drug delivery

Cited by 64 publications

References 41 publications

Effect of Polysaccharides from Bletilla striata on the Healing of Dermal Wounds in Mice

Effect of Polysaccharides from Bletilla striata on the Healing of Dermal Wounds in Mice

Microneedle-Based Natural Polysaccharide for Drug Delivery Systems (DDS): Progress and Challenges

A review on the applications of Traditional Chinese medicine polysaccharides in drug delivery systems

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