Novel cyclodehydration reaction of hydroxyphenols. An alternative to the Mitsunobu reaction

A Mild and Efficient One‐Pot Preparation of 1,2,4‐Oxadiazoles from Nitriles and Carboxylic Acids Using Vilsmeier Reagent

“…Vilsmeier reagent offers several advantages such as broad functional group tolerance, easy workup due to water‐soluble by‐products and high yield and purity of products. Although Vilsmeier reagent has been primarily used as formylating agent, a new applications have been recently developed for this reagent, for example, coupling reagent in the synthesis of esters, amides, acid chlorides, β‐sultams, β‐lactams, diacylhydrazines, 1,3,4‐oxadiazoles, 1,3,4‐thiadiazoles, oxazolones and Erlenmeyer azlactones . It is easily prepared by reaction of DMF and oxalyl chloride or thionyl chloride in dry dichloromethane …”

Synthesis of Novel β‐Lactams from Phenothiazin‐10‐ylacetic Acid

“…Chloromethylenedimethylammonium chloride (Vilsmeier reagent) 2 has been mostly used as an acid activator for the synthesis of esters , amides , β‐sultams , diacylhydrazines , 1,3,4‐oxadiazoles , and β‐lactams .…”

Synthesis of Thiazolinethione-5-Carbaldehydes by Vilsmeier-Haack formylation and transformation into Imines Chromophores

“…6 It has been extensively used for formylation of activated compounds and fully conjugated carboxylic system. 7,8 In this work we report the synthesis and the reactivity studies of thiazolcarboxaldehyde by Vilsmeier-Haack reaction from Δ-4-thiazolinethione 1a-b as starting materials. These resulting carboxaldehydes 3a-b have been used as synthones for the production of new classes of Schiff bases chromophores 6a-d.…”