Novel drug delivery systems based on triaxial electrospinning based nanofibers

Ghosal, Kajal; Augustine, Robin; Zaszczyńska, Angelika; Barman, Mrinmoy; Jain, Amrita; Hasan, Anwarul; Kalarikkal, Nandakumar; Sajkiewicz, Paweł; Thomas, Sabu

doi:10.1016/j.reactfunctpolym.2021.104895

Cited by 92 publications

(51 citation statements)

References 80 publications

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“…Recently, novel varieties of the electrospinning technique were developed in order to generate more complex nanostructures with desired features such as coaxial electrospinning [9], side-by-side [10] and tri-axial [11] electrospinning, and other multiple fluid processes. Such methods of fabrication can lead to composite structures such as coreshell, Janus, tri-layer core-shell, and other complex structures.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Polymer-Fungicide Nanocomposites for Grapevine Protection

et al. 2021

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Nowadays, diseases in plants are a worldwide problem. Fungi represent the largest number of plant pathogens and are responsible for a range of serious plant diseases. Esca is a grapevine disease caused mainly by fungal pathogens Phaeomoniella chlamydospora (P. chlamydospora) and Phaeoacremonium aleophilum (P. aleophilum). The currently proposed methods to fight esca are not curative. In this study, polymer composites based on biodegradable polymer containing chemical fungicides with antifungal activity were successfully prepared by electrospinning. The obtained materials were hydrophobic with good mechanical properties. In vitro studies demonstrated that the fungicide release was higher from PLLA/K5N8Q fibrous mats (ca. 72% for 50 h) compared to the released drug amount from PLLA/5-Cl8Q materials (ca. 52% for 50 h), which is due to the better water-solubility of the salt. The antifungal activity of the fibrous materials against P. chlamydospora and P. aleophilum was studied as well. The incorporation of the fungicide in the biodegradable fibers resulted in the inhibition of fungal growth. The obtained materials are perspective candidates for the protection of vines from the penetration and growth of fungal pathogens.

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Section: Introductionmentioning

confidence: 99%

Electrospun Polymer-Fungicide Nanocomposites for Grapevine Protection

et al. 2021

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“…Then, the polymer jet is ejected from the Taylor cone when the electric field exceeds the polymer liquid's surface tension, followed by various instabilities including bending instability of the jet due to repulsion of the electric charges on the jet surface. By modifying some parameters of the electrospinning process, of the materials, and of external conditions, such as the solution flow rate, spinneret-collector distance, the rotational speed of the collector, voltage, polymer concentration, polymer molecular weight, humidity, and temperature, the morphology and architecture of the scaffold can be dramatically changed according to the desired application [25]. Phase separation is another traditional method to produce complex and high-porosity three-dimensional scaffolds.…”

Section: Conventional Te Scaffold Fabrication Techniques Vs 3d Printing Techniquesmentioning

confidence: 99%

Advances in 3D Printing for Tissue Engineering

et al. 2021

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Tissue engineering (TE) scaffolds have enormous significance for the possibility of regeneration of complex tissue structures or even whole organs. Three-dimensional (3D) printing techniques allow fabricating TE scaffolds, having an extremely complex structure, in a repeatable and precise manner. Moreover, they enable the easy application of computer-assisted methods to TE scaffold design. The latest additive manufacturing techniques open up opportunities not otherwise available. This study aimed to summarize the state-of-art field of 3D printing techniques in applications for tissue engineering with a focus on the latest advancements. The following topics are discussed: systematics of the available 3D printing techniques applied for TE scaffold fabrication; overview of 3D printable biomaterials and advancements in 3D-printing-assisted tissue engineering.

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“…Since electrospun nanofibers could withstand contractile forces, they are attractive support as adhesion sites for cells [177,178]. Above all, the hydrogel/nanofiber composite material provides the environment that entirely mimics the structure of proteoglycans and collagen fibers in the native ECM [179].…”

Section: Hydrogels and Electrospun Nanofibersmentioning

confidence: 99%

Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering

2021

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Injuries of the bone/cartilage and central nervous system are still a serious socio-economic problem. They are an effect of diversified, difficult-to-access tissue structures as well as complex regeneration mechanisms. Currently, commercially available materials partially solve this problem, but they do not fulfill all of the bone/cartilage and neural tissue engineering requirements such as mechanical properties, biochemical cues or adequate biodegradation. There are still many things to do to provide complete restoration of injured tissues. Recent reports in bone/cartilage and neural tissue engineering give high hopes in designing scaffolds for complete tissue regeneration. This review thoroughly discusses the advantages and disadvantages of currently available commercial scaffolds and sheds new light on the designing of novel polymeric scaffolds composed of hydrogels, electrospun nanofibers, or hydrogels loaded with nano-additives.

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Novel drug delivery systems based on triaxial electrospinning based nanofibers

Cited by 92 publications

References 80 publications

Electrospun Polymer-Fungicide Nanocomposites for Grapevine Protection

Electrospun Polymer-Fungicide Nanocomposites for Grapevine Protection

Advances in 3D Printing for Tissue Engineering

Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering

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