Novel electrochemical biosensor for serotonin detection based on gold nanorattles decorated reduced graphene oxide in biological fluids and in vitro model

Mahato, Kuldeep; Purohit, Buddhadev; Bhardwaj, Keshav; Jaiswal, Amit; Chandra, Pranjal

doi:10.1016/j.bios.2019.111502

Cited by 109 publications

(34 citation statements)

References 27 publications

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“…Hence, a mediator, which facilitated electron transfer, is necessary at the interface of heterojunction. AuNPs can be a candidate intermediate owing to their large specific surface area, the ability of the charge separation promotion, and the antibody’s easy immobilization [ 48 ]. Hence, g-C 3 N 4 /Au/WO 3 composite both integrates substantial benefits and efficiently facilitates electron transport, thereby resulting in the development of a sensitive immunosensor.…”

Section: Resultsmentioning

confidence: 99%

Sensitive sandwich-type electrochemical SARS-CoV‑2 nucleocapsid protein immunosensor

et al. 2021

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Section: Resultsmentioning

confidence: 99%

Sensitive sandwich-type electrochemical SARS-CoV‑2 nucleocapsid protein immunosensor

et al. 2021

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“…Electrochemical biosensors measure the signal based on any minute difference in potential, conductance, current, or field effect that occurs because of the binding between the BRE and the analyte [ 51 , 52 ]. These systems are preferred over others because of their selectivity, sensitivity, and operational details [ 53 , 54 , 55 , 56 ]. The three electrodes typically used in an electrochemical system include; the working electrode (e.g., glassy carbon electrode functions as the transducing element); the auxiliary/counter electrode (e.g., Pt electrode, acts to complete the circuit); and the reference electrode (e.g., Ag/AgCl electrode, important for creating a steady potential) [ 24 , 57 , 58 , 59 ].…”

Section: Label and Label-free Aptasensorsmentioning

confidence: 99%

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

et al. 2022

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Viral infections are becoming the foremost driver of morbidity, mortality and economic loss all around the world. Treatment for diseases associated to some deadly viruses are challenging tasks, due to lack of infrastructure, finance and availability of rapid, accurate and easy-to-use detection methods or devices. The emergence of biosensors has proven to be a success in the field of diagnosis to overcome the challenges associated with traditional methods. Furthermore, the incorporation of aptamers as bio-recognition elements in the design of biosensors has paved a way towards rapid, cost-effective, and specific detection devices which are insensitive to changes in the environment. In the last decade, aptamers have emerged to be suitable and efficient biorecognition elements for the detection of different kinds of analytes, such as metal ions, small and macro molecules, and even cells. The signal generation in the detection process depends on different parameters; one such parameter is whether the labelled molecule is incorporated or not for monitoring the sensing process. Based on the labelling, biosensors are classified as label or label-free; both have their significant advantages and disadvantages. Here, we have primarily reviewed the advantages for using aptamers in the transduction system of sensing devices. Furthermore, the labelled and label-free opto-electrochemical aptasensors for the detection of various kinds of viruses have been discussed. Moreover, numerous globally developed aptasensors for the sensing of different types of viruses have been illustrated and explained in tabulated form.

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“…Thus, it is a crucial need indeed to develop a system that can sense and diagnose the SARS-CoV-2 infection as well by targeting it's specified-potent biomarkers in a label-free format. Electrochemical biosensors with a nano-engineered surface in recent years have become a critical area of research interest [ [13] , [14] , [15] ]. Scientists from all over the world are focusing on the exceptional atomic and molecular properties of engineered nanomaterials and their composites for better biological/diagnostic applications [ [16] , [17] , [18] , [19] ].…”

Section: The Need For Rapid Diagnosis and Point-of-care (Poc) Detectimentioning

confidence: 99%

Miniaturized label-free smartphone assisted electrochemical sensing approach for personalized COVID-19 diagnosis

Chandra

2020

Sensors International

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The COVID-19, coronavirus disease is an infectious disease caused by a novel virus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). By March 2020 the novel coronavirus known to cause a pandemic has infected nearly about 119 thousand people and killed more than 4,300 around 114 countries. Apart from the current controversial opinions about the origin, spreading, and sociological impact, it is much more imperative to put a halt to this current situation. Understanding, testing, and early to rapid diagnosis may be now the only key that can contain COVID-19 by “flattening the curve”. Biosensing is the platform that allows rapid, highly sensitive, and selective detection of analytes which in turn can serve the purpose for fast and precise detection of COVID-19. In this article, based on recently reported miniaturized sensing strategies, we hereby propose a promising personalized smartphone assisted electrochemical sensing platform for diagnosis of COVID-19.

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Novel electrochemical biosensor for serotonin detection based on gold nanorattles decorated reduced graphene oxide in biological fluids and in vitro model

Cited by 109 publications

References 27 publications

Sensitive sandwich-type electrochemical SARS-CoV‑2 nucleocapsid protein immunosensor

Sensitive sandwich-type electrochemical SARS-CoV‑2 nucleocapsid protein immunosensor

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

Miniaturized label-free smartphone assisted electrochemical sensing approach for personalized COVID-19 diagnosis

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