Novel endodontic sealer with dual strategies of dimethylaminohexadecyl methacrylate and nanoparticles of silver to inhibit root canal biofilms

Baras, Bashayer H.; Melo, Mary Anne S.; Sun, Jirun; Oates, Thomas W.; Weir, Michael D.; Xie, Xianju; Bai, Yuxing; Xu, Hockin H.K.

doi:10.1016/j.dental.2019.05.014

Cited by 34 publications

(32 citation statements)

References 66 publications

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“…Modifications to root canal sealers have been made to improve their antimicrobial properties and promote the longevity of root canal therapy. These efforts have mainly focused on the incorporations of soluble bioactive, antibacterial additives like silver, or through the copolymerization of antibacterial agents like Quaternary Ammonium Compounds (QACs) within polymeric materials to produce long lasting effects, which have gained a wide-spread interest [24][25][26][27].…”

Section: Resin-based Root Canal Sealers As Carriers For Bioactive Addmentioning

confidence: 99%

“…One possible explanation could be that the incompatible mixing of the methacrylate-based NAg into the epoxy resin-based AH Plus sealer resulted in the complete depletion of silver at day 1. When another study incorporated DMAHDM and NAg into a methacrylate-resin based experimental sealer, 0.15% NAg was able to achieve a 2 log CFU reduction against E. faecalis biofilm grown on saliva-coated resin disks, when compared to experimental control group without NAg [26]. Combining 0.15% NAg and 5% DMAHDM resulted in a 6 log CFU reduction [26].…”

Section: Silver and Silver Nanoparticlesmentioning

confidence: 99%

“…When another study incorporated DMAHDM and NAg into a methacrylate-resin based experimental sealer, 0.15% NAg was able to achieve a 2 log CFU reduction against E. faecalis biofilm grown on saliva-coated resin disks, when compared to experimental control group without NAg [26]. Combining 0.15% NAg and 5% DMAHDM resulted in a 6 log CFU reduction [26]. Sealer with 0.15% NAg was also able to significantly reduce biofilm polysaccharide production [26].…”

Section: Silver and Silver Nanoparticlesmentioning

confidence: 99%

“…Sealer with 0.15% NAg was also able to significantly reduce biofilm polysaccharide production [26]. When resin disks with NAg were observed under an epifluorescence microscope after being subjected to live/dead staining, they showed less live bacteria and more dead bacteria when compared to control resin disks without NAg [26].…”

Section: Silver and Silver Nanoparticlesmentioning

confidence: 99%

“…This can compromise the sealer-dentin bond and result in micro-gaps that can act as a source for micro-leakage [22,23]. For these specific reasons, efforts have been made to improve the bond and antibacterial properties of methacrylate-resin based root canal sealers [24][25][26][27].…”

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confidence: 99%

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Novel Bioactive and Therapeutic Root Canal Sealers with Antibacterial and Remineralization Properties

et al. 2020

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According to the American Dental Association Survey of Dental Services Rendered (published in 2007), 15 million root canal treatment procedures are performed annually. Endodontic therapy relies mainly on biomechanical preparation, chemical irrigation and intracanal medicaments which play an important role in eliminating bacteria in the root canal. Furthermore, adequate obturation is essential to confine any residual bacteria within the root canal and deprive them of nutrients. However, numerous studies have shown that complete elimination of bacteria is not achieved due to the complex anatomy of the root canal system. There are several conventional antibiotic materials available in the market for endodontic use. However, the majority of these antibiotics and antiseptics provide short-term antibacterial effects, and they impose a risk of developing antibacterial resistance. The root canal is a dynamic environment, and antibacterial and antibiofilm materials with long-term effects and nonspecific mechanisms of action are highly desirable in such environments. In addition, the application of acidic solutions to the root canal wall can alter the dentin structure, resulting in a weaker and more brittle dentin. Root canal sealers with bioactive properties come in direct contact with the dentin wall and can play a positive role in bacterial elimination and strengthening of the root structure. The new generation of nanostructured, bioactive, antibacterial and remineralizing additives into polymeric resin-based root canal sealers are discussed in this review. The effects of these novel bioactive additives on the physical and sealing properties, as well as their biocompatibility, are all important factors that are presented in this article.

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Section: Resin-based Root Canal Sealers As Carriers For Bioactive Addmentioning

confidence: 99%

Section: Silver and Silver Nanoparticlesmentioning

confidence: 99%

Section: Silver and Silver Nanoparticlesmentioning

confidence: 99%

Section: Silver and Silver Nanoparticlesmentioning

confidence: 99%

mentioning

confidence: 99%

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Novel Bioactive and Therapeutic Root Canal Sealers with Antibacterial and Remineralization Properties

et al. 2020

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Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

et al. 2021

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The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally-administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow. For systemically-administered medications, drug resistance and adverse side-effects are issues that need to be resolved. New strategies for drug delivery have been investigated over the last decade to overcome these obstacles. Synthesis of nanoparticle-containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues. Micro/nanoencapsulants with unique structures and properties function as more favorable drug-release platforms than conventional treatment approaches. The present review provides an overview of newly-developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine.

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Bio-based Nanomaterials in Dentistry

Omid,

Banakar,

Mousavi

et al. 2024

Biobased Nanomaterials

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Novel endodontic sealer with dual strategies of dimethylaminohexadecyl methacrylate and nanoparticles of silver to inhibit root canal biofilms

Cited by 34 publications

References 66 publications

Novel Bioactive and Therapeutic Root Canal Sealers with Antibacterial and Remineralization Properties

Novel Bioactive and Therapeutic Root Canal Sealers with Antibacterial and Remineralization Properties

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

Bio-based Nanomaterials in Dentistry

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