Novel Evidence-Based Combination of Plant Extracts with Multitarget Mechanisms of Action for the Elimination of Hot Flashes during Menopause

Tsoumani, Maria; Nikolaou, Panagiota; Argyropoulou, Aikaterini; Tseti, Ioulia; Mitakou, Sofia; Andreadou, Ioanna

doi:10.3390/molecules27041221

Cited by 4 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, hot flashes are a common stressful symptom for individuals with cancer and other diseases (34). Therefore, studies in pathophysiology and treatment of hot flashes are becoming prevalent (35)(36)(37).…”

Section: Related Symptoms Like Hot Flashesmentioning

confidence: 99%

Global hotspots and prospects of perimenopausal depression: A bibliometric analysis via CiteSpace

et al. 2022

View full text Add to dashboard Cite

BackgroundPerimenopausal depression (PMD) is characterized by affective symptoms as well as menopause-specific somatic complaints and has attracted increasing attention over the past few decades. Using a bibliometric tool, this study aims to evaluate the origin, current hotspots, and research trends on PMD.MethodsArticles with research on PMD were retrieved from Web of Science Core Collection (WoSCC). We used the bibliometric method to analyze publication years, journals, countries, institutions, authors, research hotspots, and trends. We plotted the reference co-citation network and used keywords to analyze the research hotspots and trends.ResultsA total of 209 publications related to PMD were identified from WoSCC on May 8, 2022. The number of publications concerning PMD every year shows an upward trend. Further analysis indicated that 209 articles were contributed by 45 countries, 288 institutions, and 501 authors. The United States contributed the most significant number of publications, followed by China. Harvard University is the core institution of PMD research, and Cohen’s work has had an important impact on another research. The occurrence and pathological mechanisms of depression during the menopausal transition from the knowledge base of PMD. All of them belong to the category of gynecology and psychosis, which reflects the focus of the research topics. Major depression, postmenopausal women, symptoms like hot flashes, and prevalence and risk factors are research hotspots in the PMD field. The frontiers in PMD field that will impact future research are anxiety, meta-analysis, association, and Beck Depression Inventory-II (BDI-II).ConclusionThese findings provide us with the core countries, institutions, and authors in PMD research and point out the direction of attention in this field. The current research focuses on depression, postmenopausal women, hot flashes, and other symptoms, as well as the prevalence and risk factors. The frontiers will be anxiety, meta-analysis, related factors, and depression assessment in future research.

show abstract

Section: Related Symptoms Like Hot Flashesmentioning

confidence: 99%

Global hotspots and prospects of perimenopausal depression: A bibliometric analysis via CiteSpace

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Menopausal symptoms resulting from ovarian failure commonly cause menopausal women to consult their physicians (hot flashes, bone mass loss, urinary complaints, vaginal dryness, and dyspareunia caused by vaginal atrophy) [ 1 , 4 ]. This period is characterized by the loss of hormonal function of the ovaries that dramatically affects the female reproductive system, inducing changes in uterus, vagina, and vulva structure, microbiome, local immunity, and functioning [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Effects on the Reproductive System in Ovariectomized Rats: Deciphering Possible Mechanisms

et al. 2022

View full text Add to dashboard Cite

Phytoestrogen resveratrol (R) has been demonstrated to benefit human reproductive health. However, R bioavailability and pharmacokinetics are still problematic under oral supplementation. We used an experimental vaginal gel with R and hyaluronic acid (HA) to improve bioavailability and pharmacokinetic properties. The study aimed to assess the impact of vaginal R-HA gel on the reproductive system in ovariectomized rats. Methods: The study was carried out on Wistar female rats. It investigated the body weight, tail temperature, vaginal pH, estrogen and progesterone blood levels, and immunohistochemical biomarkers (COX2, Casp-3, Bcl-2, and VEGF). Animals were divided into control animals; ovariectomized rats (OVX); and OVX group treated with vaginal 0.5% R-HA gel (0.5%, 0.1 mL, daily 28 days). Results: The R-HA gel’s therapeutic effect was manifested by slowing weight gain by 17% (p < 0.001), less pronounced symptom of fever at the root of the tail by 9% (p < 0.001) and lowering the vaginal pH to 4.4–4.5 compared with OVX rats. The anti-inflammatory effect and the reduction of COX-2 expression in vagina were accompanied by antiapoptotic impact of RA-H on endometrium, associated with the decreased Casp-3 expression (p < 0.001) and elevated Bcl-2 score in endometrial glands (p = 0.01). Together with enhanced VEGF expression in endometrial glands (p < 0.001) and stromal cells (p = 0.007), these changes prevented endometrial atrophy (p < 0.001) after ovariectomy. Thus, this study substantiates the feasibility of developing an innovative topical drug with R and HA for treating hypoestrogenic disorders.

show abstract

Protective effect of vaginal resveratrol administration on joint tissues in ovariectomized rats: Targeting mTOR and сaspase 3

Zaychenko

Бєленічев

Hnatiuk

et al. 2023

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

Novel Evidence-Based Combination of Plant Extracts with Multitarget Mechanisms of Action for the Elimination of Hot Flashes during Menopause

Cited by 4 publications

References 44 publications

Global hotspots and prospects of perimenopausal depression: A bibliometric analysis via CiteSpace

Global hotspots and prospects of perimenopausal depression: A bibliometric analysis via CiteSpace

Resveratrol Effects on the Reproductive System in Ovariectomized Rats: Deciphering Possible Mechanisms

Protective effect of vaginal resveratrol administration on joint tissues in ovariectomized rats: Targeting mTOR and сaspase 3

Contact Info

Product

Resources

About