Novel functions of S1P in chronic itchy and inflammatory skin diseases

Gray, Natalie; Limberg, Maren M.; Bräuer, Anja U.; Raap, Ulrike

doi:10.1111/jdv.17764

Cited by 11 publications

(6 citation statements)

References 72 publications

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“…Our group recently discovered that isolated basophils of atopic patients exhibited decreased S1PR1 expression, and possessed intracellular S1P in isolated basophils ( 31 ). Furthermore, in the stratum corneum of AD patients, the lipid is decreased, which might alleviate colonization with Staphylococcus aureus ( 69 ). The lipid, as well as mRNA expression of the S1P receptors (S1PR) S1PR1, S1PR2, S1PR3 and S1PR4, have been observed in human basophils ( Figure 1 ) ( 31 ).…”

Section: Atopic Dermatitismentioning

confidence: 99%

Basophils in pruritic skin diseases

et al. 2023

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Basophils are rare cells in the peripheral blood which have the capability to infiltrate into the skin. Invasion of basophils has been detected in pruritic skin diseases, including atopic dermatitis, bullous pemphigoid, chronic spontaneous urticaria and contact dermatitis. In the skin, basophils are important players of the inflammatory immune response, as they release Th2 cytokines, including interleukin (IL)-4 and IL-13, subsequently inducing the early activation of T-cells. Further, basophils release a multitude of mediators, such as histamine and IL-31, which both play an important role in the initiation of the pruritic response via activation of sensory nerves. Chronic pruritus significantly affects the quality of life and the working capability of patients, though its mechanisms are not fully elucidated yet. Since basophils and neurons share many receptors and channels, bidirectional interaction mechanisms, which drive the sensation of itch, are highlighted in this review.

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Section: Atopic Dermatitismentioning

confidence: 99%

Basophils in pruritic skin diseases

et al. 2023

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“…Although many effects of S1P signaling in the human organism have been discovered, the full extent of its functions has not been elucidated yet. It is now becoming clear that dysfunction or imbalance of the S1P axis is a contributing factor in inflammatory skin diseases such as atopic dermatitis and psoriasis [ 67 ].…”

Section: S1p-s1pr Signaling and Skin Diseasesmentioning

confidence: 99%

Sphingosine 1-Phosphate Signaling at the Skin Barrier Interface

Masuda-Kuroki

Nardo

2022

Biology

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Sphingosine 1-phosphate (S1P) is a product of membrane sphingolipid metabolism. S1P is secreted and acts via G-protein-coupled receptors, S1PR1-5, and is involved in diverse cellular functions, including cell proliferation, immune suppression, and cardiovascular functions. Recent studies have shown that the effects of S1P signaling are extended further by coupling the different S1P receptors and their respective downstream signaling pathways. Our group has recently reported that S1P inhibits cell proliferation and induces differentiation in human keratinocytes. There is a growing understanding of the connection between S1P signaling, skin barrier function, and skin diseases. For example, the activation of S1PR1 and S1PR2 during bacterial invasion regulates the synthesis of inflammatory cytokines in human keratinocytes. Moreover, S1P-S1PR2 signaling is involved in the production of inflammatory cytokines and can be triggered by epidermal mechanical stress and bacterial invasion. This review highlights how S1P affects human keratinocyte proliferation, differentiation, immunoreaction, and mast cell immune response, in addition to its effects on the skin barrier interface. Finally, studies targeting S1P-S1PR signaling involved in inflammatory skin diseases are also presented.

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“…In recent years, lipid metabolism dysfunction in patients with PSO has been reported [ [4] , [5] , [6] ]. Studies have shown a significant increase in the concentration of sphingosine-1-phosphate (S1P), a type of sphingolipid, in the serum of patients with PSO [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Xiaoyin Jiedu Granules may alleviate psoriasis-like skin diseases in mice by regulating sphingosine 1-phosphate receptor expression and reducing Th17 cells

Wang,

Zhang,

Zhang

et al. 2023

Heliyon

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Novel functions of S1P in chronic itchy and inflammatory skin diseases

Cited by 11 publications

References 72 publications

Basophils in pruritic skin diseases

Basophils in pruritic skin diseases

Sphingosine 1-Phosphate Signaling at the Skin Barrier Interface

Xiaoyin Jiedu Granules may alleviate psoriasis-like skin diseases in mice by regulating sphingosine 1-phosphate receptor expression and reducing Th17 cells

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