Novel graphene oxide-containing antibacterial mesoporous bioactive glass

Shih, Shao‐Ju; Hong, Bo-Jiang; Lin, Yueqiang

doi:10.1016/j.ceramint.2017.05.197

Cited by 16 publications

(10 citation statements)

References 35 publications

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“…As shown in Figure 8(c), MBN sample showed a very high formation of calcite as in vitro bioactivity (i.e., IP-O/ISi-O-Si) decreased at 5 days, and HAp was formed at 30 days as formation of calcite (i.e., ICalcite/IMBN) was gradually degraded with increasing in vitro bioactivity [25,26]. The data of Figure 8(c) suggest the correlation between HAp formation and the degradation of calcite in the in vitro interaction of bioactive glass with SBF.…”

Section: In Vitro Bioactivity and Hap Formation Process Of Mbn And Mbmentioning

confidence: 89%

“…In the FESEM image, calcite appeared in the form of clusters on the surface of the bioactive glass particles, and hydroxyapatite was observed in the form of flakes or needle shape. As shown in Figure 9, SEM images of MBN specimens showed that calcite appears to As shown in Figure 8c, MBN sample showed a very high formation of calcite as in vitro bioactivity (i.e., I P-O /I Si -O -Si ) decreased at 5 days, and HAp was formed at 30 days as formation of calcite (i.e., I Calcite /I MBN ) was gradually degraded with increasing in vitro bioactivity [25,26]. The data of Figure 8c suggest the correlation between HAp formation and the degradation of calcite in the in vitro interaction of bioactive glass with SBF.…”

Section: In Vitro Bioactivity and Hap Formation Process Of Mbn And Mbmentioning

confidence: 89%

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Mesoporous Bioactive Glass Combined with Graphene Oxide Quantum Dot as a New Material for a New Treatment Option for Dentin Hypersensitivity

et al. 2020

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Dentin hypersensitivity is one of the most common clinical conditions usually associated with exposed dentinal tubules. The purpose of this study was to identify the potential of a graphene oxide quantum dot coating for mesoporous bioactive glass nanoparticles as a new material for the treatment of dentin hypersensitivity by investigating its mineralization activity and dentinal tubules sealing. Mesoporous bioactive glass nanoparticle was fabricated by modified sol-gel synthesis. X-ray diffraction was performed to characterize the synthesized nanoparticle Fourier transform infra-red spectroscopy investigated the functionalized surfaces. The distribution of the specific surface area and the pore size was measure by Pore size analysis. The morphology of sample was observed by Field Emission Scanning Electron Microscope (FESEM) and Field Emission Transmission Electron Microscope (FETEM). After disk-shaped specimens of mesoporous bioactive glass nanoparticles and graphene oxide quantum dot coated mesoporous bioactive glass nanoparticles (n = 3) were soaked in the simulated body fluid for 0, 1, 5, 10,and 30 days, the amount of ions released was observed to confirm the ionic elution for mineralization. Sensitive tooth model discs (n = 20) were applied with two samples and evaluated the dentinal tubule sealing ability. The spherical mesoporous bioactive glass nanoparticles and graphene oxide quantum dot coated mesoporous bioactive glass nanoparticles with a diameter of about 500 nm were identified through FESEM and FETEM. The ion release capacity of both samples appeared to be very similar. The amount of ion released and in vitro mineralization tests confirmed that graphene oxide quantum dot coating of mesoporous bioactive glass nanoparticles did not inhibit the release of calcium, silicon and phosphate ions, but rather that graphene oxide quantum dot promoted hydroxyapatite formation. In the FESEM image of the sensitive tooth disc surface, it was observed that graphene oxide quantum dot coated mesoporous bioactive glass nanoparticles sealed tightly the dentinal tubules. The graphene oxide quantum dot coating of mesoporous bioactive glass nanoparticles not only showed the excellent dentinal sealing ability but also rapidly promoted mineralization while minimizing the size increase by coating the mesoporous bioactive glass nanoparticles.

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Section: In Vitro Bioactivity and Hap Formation Process Of Mbn And Mbmentioning

confidence: 89%

Section: In Vitro Bioactivity and Hap Formation Process Of Mbn And Mbmentioning

confidence: 89%

Mesoporous Bioactive Glass Combined with Graphene Oxide Quantum Dot as a New Material for a New Treatment Option for Dentin Hypersensitivity

et al. 2020

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“…[111] Bioactive and antibacterial properties of GMs and GM-based nanocomposites are also promising for dental applications. In two recent studies, [115,116] Shih et al have demonstrated that nitrogen-doped GO-containing bioglass exhibits enhanced antibacterial activity against E. coli, relative to both the GO-containing and bare bioglasses. [112] Another group tested the potential of GMs as antibacterial additives for bone-mimicking ceramic materials, bioactive glasses.…”

Section: Functionalization Of Medical Device Surfacesmentioning

confidence: 99%

Graphene Materials in Antimicrobial Nanomedicine: Current Status and Future Perspectives

Karahan

Wiraja

et al. 2018

Adv Healthcare Materials

183

142

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Graphene materials (GMs), such as graphene, graphene oxide (GO), reduced GO (rGO), and graphene quantum dots (GQDs), are rapidly emerging as a new class of broad-spectrum antimicrobial agents. This report describes their state-of-the-art and potential future covering both fundamental aspects and biomedical applications. First, the current understanding of the antimicrobial mechanisms of GMs is illustrated, and the complex picture of underlying structure-property-activity relationships is sketched. Next, the different modes of utilization of antimicrobial GMs are explained, which include their use as colloidal dispersions, surface coatings, and photothermal/photodynamic therapy agents. Due to their practical relevance, the examples where GMs function as synergistic agents or release platforms for metal ions and/or antibiotic drugs are also discussed. Later, the applicability of GMs in the design of wound dressings, infection-protective coatings, and antibiotic-like formulations ("nanoantibiotics") is assessed. Notably, to support our assessments, the existing clinical applications of conventional carbon materials are also evaluated. Finally, the key hurdles of the field are highlighted, and several possible directions for future investigations are proposed. We hope that the roadmap provided here will encourage researchers to tackle remaining challenges toward clinical translation of promising research findings and help realize the potential of GMs in antimicrobial nanomedicine.

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“…Previous studies have loaded MBG with copper, silver (Ag), and graphene oxide as antibacterial agents. These materials release ions to bond with the cell membrane, causing membrane rupture and cell apoptosis due to surface charge imbalance (Asharani et al, 2009;Mcshan et al, 2014;Shih et al, 2017). In osseointegrated applications, low concentrations of strontium (Sr) ions can induce osteocalcin, bone sialoprotein, and osteoblast proliferation with high expression of alkaline phosphatase (ALP) to avoid osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Angiogenesis, Osseointegration, and Antibacterial Applications of Polyelectrolyte Multilayer Coatings Incorporated With Silver/Strontium Containing Mesoporous Bioactive Glass on 316L Stainless Steel

Kuo

Chen

Dash

et al. 2022

Front. Bioeng. Biotechnol.

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The main causes for failure in implant surgery are prolonged exposure of implants or wound and tissue ischemia. Bacterial infection caused by the surrounding medical environment and equipment is also a major risk factor. The medical risk would be greatly reduced if we could develop an implant coating to guide tissue growth and promote antibacterial activity. Mesoporous bioactive glasses are mainly silicates with good osteoinductivity and have been used in medical dentistry and orthopedics for several decades. Strontium ions and silver ions could plausibly be incorporated into bioactive glass to achieve the required function. Strontium ions are trace elements in human bone that have been proposed to promote osseointegration and angiogenesis. Silver ions can cause bacterial apoptosis through surface charge imbalance after bonding to the cell membrane. In this study, functional polyelectrolyte multilayer (PEM) coatings were adhered to 316L stainless steel (SS) by spin coating. The multilayer film was composed of biocompatible and biodegradable collagen as a positively charged layer, γ-polyglutamic acid (γ-PGA) as a negatively charged layer. Chitosan was incorporated to the 11th positively charged layer as a stabilizing barrier. Spray pyrolysis prepared mesoporous bioactive glass incorporated with silver and strontium (AgSrMBG) was added to each negatively charged layer. The PEM/AgSrMBG coating was well hydrophilic with a contact angle of 37.09°, hardness of 0.29 ± 0.09 GPa, Young’s modulus of 5.35 ± 1.55 GPa, and roughness of 374.78 ± 22.27 nm, as observed through nano-indention and white light interferometry. The coating’s antibacterial activity was sustained for 1 month through the inhibition zone test, and was biocompatible with rat bone marrow mesenchymal stem cells (rBMSCs) and human umbilical vein endothelial cells (HUVECs), as observed in the MTT assay. There was more hydroxyapatite precipitation on the PEM/AgSrMBG surface after being soaked in simulated body fluid (SBF), as observed by scanning electron microscopy (SEM) and X-ray diffraction (XRD). In both in vitro and in vivo tests, the PEM/AgSrMBG coating promoted angiogenesis, osseointegration, and antibacterial activity due to the sustained release of silver and strontium ions.

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Novel graphene oxide-containing antibacterial mesoporous bioactive glass

Cited by 16 publications

References 35 publications

Mesoporous Bioactive Glass Combined with Graphene Oxide Quantum Dot as a New Material for a New Treatment Option for Dentin Hypersensitivity

Mesoporous Bioactive Glass Combined with Graphene Oxide Quantum Dot as a New Material for a New Treatment Option for Dentin Hypersensitivity

Graphene Materials in Antimicrobial Nanomedicine: Current Status and Future Perspectives

Angiogenesis, Osseointegration, and Antibacterial Applications of Polyelectrolyte Multilayer Coatings Incorporated With Silver/Strontium Containing Mesoporous Bioactive Glass on 316L Stainless Steel

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