Novel indole-based melatonin analogues: Evaluation of antioxidant activity and protective effect against amyloid β-induced damage

Gürer-Orhan, Hande; Karaaslan, Çiğdem; Ozcan, Senem; Firuzi, Omidreza; Tavakkoli, Marjan; Saso, Luciano; Süzen, Síbel

doi:10.1016/j.bmc.2016.02.039

Cited by 49 publications

(26 citation statements)

References 35 publications

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“…Many antioxidants including resveratrol have been reported to inhibit the cytotoxicity of Aβ peptides (24)(25)(26). These findings are contradictory to our negative results of resveratrol ( Figure 4).…”

Section: Discussioncontrasting

confidence: 99%

Protection of Differentiating Neuronal Cells from Amyloid β Peptide-induced Injury by Alkaline Extract of Leaves of Sasa senanensis Rehder

Sakagami

Tsuji

Tomomura

et al. 2018

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Section: Discussioncontrasting

confidence: 99%

Protection of Differentiating Neuronal Cells from Amyloid β Peptide-induced Injury by Alkaline Extract of Leaves of Sasa senanensis Rehder

Sakagami

Tsuji

Tomomura

et al. 2018

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“…Suzen and co‐workers report the synthesis of a series of new indole‐based hydrazide/hydrazone derivatives 35 a – n and 36 (Figure ) and investigate their antioxidant activity in human erythrocytes by evaluating their reducing effect against oxidation of a redox‐sensitive fluorescent probe . Hydrazone derivatives 35 a , 35 b , and 35 c containing o ‐halophenyl substituents and 35 d with a 3,5‐difluorophenyl substituent show excellent antioxidant properties, whereas, 36 —the only hydrazide compound in the series—has a slight pro‐oxidant effect.…”

Section: Discussionmentioning

confidence: 99%

Benzofuran and Indole: Promising Scaffolds for Drug Development in Alzheimer's Disease

2018

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Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically accepted treatment to cure or halt its progression. The Food and Drug Administration has approved drugs (e.g., rivastigmine, donepezil, galantamine, and memantine) that at best provide marginal benefits, thus emphasizing the urgent need to explore other molecular entities as future drug candidates for AD. Looking at the wide pharmaceutical applications of heterocyclic compounds and particularly those containing benzofuran and indole ring systems, these molecular frameworks have drawn special attention from medicinal chemists for further evaluation in numerous diseases. This article focuses on the history and recent advances of benzofuran- and indole-based compounds as inhibitors of butyrylcholinesterase, acetylcholinesterase, γ-secretase, β-secretase, tau misfolding, and β-amyloid aggregation.

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“…Neurotoxicity induced by amyloid-β peptides are caused by mitochondrial dysfunction and oxidative stress (18), alteration of metal ion influx (19), endoplasmic reticulum stress (20) and impaired autophagy (21). Amyloid β-induced neuronal cell death may be partially alleviated by antioxidants (22)(23)(24). DHA, ALC, NAC and sodium ascorbate protected from neuronal toxicity, but only partially ( Figure 5).…”

Section: Discussionmentioning

confidence: 99%

Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants

Hara

Sakagami

Shi

et al. 2018

In Vivo

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Abstract. Background Paclitaxel is an anticancer drug that inhibits calcium-induced depolymerization of tubulin and thus blocks the progression of mitosis (1). It is clinically applied for the treatment of ovarian, breast, stomach and non-small cell lung cancer (2, 3). When used clinically, it causes severe side-effects such as leucopenia. thrombocytopenia, neutropenia and fatigue (4) and anorexia and constipation (5). Patients who received platinum treatment with a taxane were more likely to experience grade 2 to 4 neuropathy (6). Paclitaxel has been reported to induce oxidative stress in liver (slight, but no significant decrease in glutathione in liver) (7). Considering many beneficial effects of antioxidants under optimal conditions (usually achieved by adopting lower doses that stimulate growth) (8, 9), prevention of chemotherapeutic drug-induced neurotoxicity by antioxidants has been actively studied in recent years (10,11).In order to search for substances that reduce neurotoxicity induced by paclitaxel, we first investigated whether nerve growth factor (NGF)-induced differentiating rat neuronal cells (used as neuron model) are also very sensitive to paclitaxel, like malignant cells. The possible protective activity of four antioxidants, docosahexaenoic acid (DHA), acetyl-L-carnitine hydrochloride (ALC), N-acetyl-L-cysteine (NAC) and sodium ascorbate, against neurotoxicity of paclitaxel was then investigated. 745

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Novel indole-based melatonin analogues: Evaluation of antioxidant activity and protective effect against amyloid β-induced damage

Cited by 49 publications

References 35 publications

Protection of Differentiating Neuronal Cells from Amyloid β Peptide-induced Injury by Alkaline Extract of Leaves of Sasa senanensis Rehder

Protection of Differentiating Neuronal Cells from Amyloid β Peptide-induced Injury by Alkaline Extract of Leaves of Sasa senanensis Rehder

Benzofuran and Indole: Promising Scaffolds for Drug Development in Alzheimer's Disease

Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants

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