Novel indolyl-pyrimidine derivatives: synthesis, antimicrobial, and antioxidant evaluations

Synthesis and Antimicrobial Activity of Some 2-Amino-4-(7- Substituted/Unsubstituted Coumarin-3-yl)-6-(Chlorosubstitutedphenyl) Pyrimidines

“…All reagents used in the present work were of analytical grade. The 2-amino-4-(7-substituted/unsubstitutedcoumarin-3-yl)-6-(chlorosubstitutedphenyl)pyrimidines (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) were prepared according to the method outlined in Scheme 1.…”

“…Pyrimidine derivatives have an important place in medicinal chemistry as these are associated with a broad range of biological activities [2,3] including antimicrobial activity [4][5][6][7]. Recently, the significance and biological importance of pyrimidine derivatives including their clinical applications in the microbial world has been reviewed [8].…”

Synthesis and antimicrobial activity of some 2- Piperidinomethylamino-4-(7-H/substituted coumarin-3-yl)- 6-chlorosubstitutedphenyl pyrimidines

“…Pyrimidine derivatives have an important place in medicinal chemistry as these are associated with a broad range of biological activities [2][3][4][5][6][7] including antimicrobial activity [8][9][10][11][12][13]. The clinical importance of pyrimidine nucleus is also evident by the marketing of clinically used pyrimidine derivatives as well as fused pyrimidine derivatives; for example, as antineoplastic agent (tegafur), as vasodilator (dipyridamole), as expectorant (tasuldine) and as antibacterial agent (trimethoprim, piromidic acid, tetroxoprim, metioprim), as antifungal agent (flucytosine), and as antiviral agent (broxuridine, idoxuridine) [14].…”

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“…Pyrimidine derivatives exhibited various biological activities such as anti-proliferative 24 , anticancer 25,26 , antihypertensive 27 , antioxidant 28,29 , antiviral 30 , antiinflammatory and analgesic activities 31,32 . Certain pyrimidine derivatives play a significant role in several biological processes and show, antileishmanial activities 33 and CNS depressant properties 34 .…”