2021
DOI: 10.3390/nano11030789
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Novel Inorganic Nanomaterial-Based Therapy for Bone Tissue Regeneration

Abstract: Extensive bone defect repair remains a clinical challenge, since ideal implantable scaffolds require the integration of excellent biocompatibility, sufficient mechanical strength and high biological activity to support bone regeneration. The inorganic nanomaterial-based therapy is of great significance due to their excellent mechanical properties, adjustable biological interface and diversified functions. Calcium–phosphorus compounds, silica and metal-based materials are the most common categories of inorganic… Show more

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Cited by 33 publications
(24 citation statements)
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“…Regarding metallic materials, such as Ti and alloys, they possess a remarkable strength and stress absorption capacity that could overcome the drawbacks of low mechanical properties of polymers and the brittleness of ceramics. [343] Moreover, several polymeric (natural and synthetic) materials have been employed for bone tissue engineering purposes and many properties can affect their biocompatibility such as material chemistry, molecular weight, solubility, shape, and structure of the implant, hydrophilicity/hydrophobicity, water absorption, lubricity, surface energy, and degradation rates. It is worth to remark that no polymer type possesses the ideal properties for all applications.…”
Section: Discussionmentioning
confidence: 99%
“…Regarding metallic materials, such as Ti and alloys, they possess a remarkable strength and stress absorption capacity that could overcome the drawbacks of low mechanical properties of polymers and the brittleness of ceramics. [343] Moreover, several polymeric (natural and synthetic) materials have been employed for bone tissue engineering purposes and many properties can affect their biocompatibility such as material chemistry, molecular weight, solubility, shape, and structure of the implant, hydrophilicity/hydrophobicity, water absorption, lubricity, surface energy, and degradation rates. It is worth to remark that no polymer type possesses the ideal properties for all applications.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, they are not bioabsorbable, and their long-term safety is unknown. Titanium-based nanomaterials exhibit high load-bearing strength and biocompatibility, but are not bioresorbable and have a slow biological response and low antimicrobial resistance [ 21 ]. Lastly, liposomes possess excellent drug-retention ability [ 22 ], but are unsuitable for forming scaffolds on their own, since they cannot be processed into fibrous forms, such as polymers.…”
Section: Promising Nanomaterials For Bone Regeneration Materialsmentioning
confidence: 99%
“…Understandably, an ideal bone scaffold is expected to possess these properties ( Ricciardi and Bostrom, 2013 ): 1) a match between the shape and size of the scaffold with the irregular and customized recipient site; 2) adequate porosity for new bone growth and new vessels; 3) mechanical properties consistent with the surrounding native bone; 4) cytocompatibility and biocompatibility of the scaffold; and 5) osteoconductivity and osteoinductivity of the scaffold materials. Therefore, a variety of biomaterials and manufacturing methods have been developed to fabricate patient-specific bone scaffolds in the past decades for repairing bone defects ( Fu et al, 2021 ; Zhang et al, 2021 ; Zhao et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%