Novel lanthanide–polymer complexes for dye-free dual modal probes for MRI and fluorescence imaging

Cao, Fangyi; Huang, Tongcun; Wang, Yifei; Liu, Fei; Chen, Lumin; Ling, Jun; Sun, Jihong

doi:10.1039/c5py01011j

Cited by 35 publications

(22 citation statements)

References 52 publications

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“…Organic dyes or inorganic quantum dots (QDs) are commonly chosen to combine with superparamagnetic iron oxides (SPIO) or gadolinium (Gd) chelates for fabrication of dual‐mode imaging probes . However, both of the organic dyes and QDs have their disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Controlled aggregation of amphiphilic aggregation‐induced emission polycation and superparamagnetic iron oxide nanoparticles as fluorescence/magnetic resonance imaging probes

Cai

Liu

et al. 2019

J of Applied Polymer Sci

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Fluorescence/magnetic resonance (MR) dual‐mode imaging, which combines the excellent single‐cell sensitivity of fluorescence imaging and the high spatial resolution of MR imaging, has been applied to different biomedical applications. However, the aggregation‐caused quenching characteristic of most fluorescence molecules often put limits in their applications. Herein, a fluorescence/MR dual‐mode imaging probe [polyethylene glycol‐polyethylenimine‐tetraphenylethene (PEG‐PEI‐TPE)/superparamagnetic iron oxide (SPIO)] with aggregation‐induced emission characteristic is prepared by coupling poly(acrylic acid)‐coated SPIO with PEG‐PEI‐TPE. The fluorescence intensity and lifetime of PEG‐PEI‐TPE/SPIO is higher than PEG‐PEI‐TPE especially at lower polymer concentrations (≤0.2 mg mL−1). Moreover, the fluorescence intensity of PEG‐PEI‐TPE/SPIO gradually increased along with the decline of the pH from 9.0 to 4.0, which is beneficial for studying intracellular organelles. The T2 relaxivity of PEG‐PEI‐TPE/SPIO is 212.3 Fe mM−1 s−1 under a 3.0 T MR scanner. Cell labeling experiment shows that PEG‐PEI‐TPE/SPIO can effectively label RAW 264.7 and Hela cells, and labeled cells are visible under both fluorescence and clinical MR examinations. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48760.

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Section: Introductionmentioning

confidence: 99%

Controlled aggregation of amphiphilic aggregation‐induced emission polycation and superparamagnetic iron oxide nanoparticles as fluorescence/magnetic resonance imaging probes

Cai

Liu

et al. 2019

J of Applied Polymer Sci

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“…Materials 1-(4-Hydroxyphenyl)-3-phenylpropane-1,3-dione (DIK) and 4-(3oxo-3-phenylpropanoyl)phenyl methacrylate (DKMA) were prepared according to our previous report. 30 1-(4-Hydroxyphenyl)ethanone (Energy Chemical), methyl benzoate (Sinopharm Chemical Reagent), 2,2 0 -azoisobutyronitrile (AIBN, 98%, Aldrich) was recrystallized twice from ethanol. Cumyl dithiobenzoate (CDB) was synthesized as reported.…”

Section: Methodsmentioning

confidence: 99%

Europium(iii) β-diketone complex as portable luminescent chemosensor for naked eye Cu²⁺ detection and recyclable on–off–on vapor response

et al. 2015

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“…Deep tissue imaging technique is instrumental for cancer diagnosis as well as cancer therapy . For example, near‐infrared (NIR, 650–1700 nm) fluorescence imaging permits deep tissue penetration and minimized interference from tissue autofluorescence . Especially light in the second NIR window (NIR‐II, 1000–1700 nm) provides additional advantages including minimized tissue light scattering and better spatial resolution .…”

Section: Introductionmentioning

confidence: 99%

Organic Dye Based Nanoparticles for Cancer Phototheranostics

Cai

Huang

et al. 2018

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Phototheranostics, which simultaneously combines photodynamic and/or photothermal therapy with deep-tissue diagnostic imaging, is a promising strategy for the diagnosis and treatment of cancers. Organic dyes with the merits of strong near-infrared absorbance, high photo-to-radical and/or photothermal conversion efficiency, great biocompatibility, ready chemical structure fine-tuning capability, and easy metabolism, have been demonstrated as attractive candidates for clinical phototheranostics. These organic dyes can be further designed and fabricated into nanoparticles (NPs) using various strategies. Compared to free molecules, these NPs can be equipped with multiple synergistic functions and show longer lifetime in blood circulation and passive tumor-targeting property via the enhanced permeability and retention effect. In this article, the recent progress of organic dye-based NPs for cancer phototheranostic applications is summarized, which extends the anticancer arsenal and holds promise for clinical uses in the near future.

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Novel lanthanide–polymer complexes for dye-free dual modal probes for MRI and fluorescence imaging

Abstract: High-resolution imaging is a powerful technique in theranostics and staging of tumors.

Cited by 35 publications

References 52 publications

Controlled aggregation of amphiphilic aggregation‐induced emission polycation and superparamagnetic iron oxide nanoparticles as fluorescence/magnetic resonance imaging probes

Controlled aggregation of amphiphilic aggregation‐induced emission polycation and superparamagnetic iron oxide nanoparticles as fluorescence/magnetic resonance imaging probes

Europium(iii) β-diketone complex as portable luminescent chemosensor for naked eye Cu²⁺ detection and recyclable on–off–on vapor response

Organic Dye Based Nanoparticles for Cancer Phototheranostics

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Novel lanthanide–polymer complexes for dye-free dual modal probes for MRI and fluorescence imaging

Abstract: High-resolution imaging is a powerful technique in theranostics and staging of tumors.

Cited by 35 publications

References 52 publications

Controlled aggregation of amphiphilic aggregation‐induced emission polycation and superparamagnetic iron oxide nanoparticles as fluorescence/magnetic resonance imaging probes

Controlled aggregation of amphiphilic aggregation‐induced emission polycation and superparamagnetic iron oxide nanoparticles as fluorescence/magnetic resonance imaging probes

Europium(iii) β-diketone complex as portable luminescent chemosensor for naked eye Cu2+ detection and recyclable on–off–on vapor response

Organic Dye Based Nanoparticles for Cancer Phototheranostics

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Europium(iii) β-diketone complex as portable luminescent chemosensor for naked eye Cu²⁺ detection and recyclable on–off–on vapor response