Novel lignin–chitosan–PVA composite hydrogel for wound dressing

Zhang, Yiwen; Jiang, Miaomiao; Zhang, Yuqing; Cao, Qiping; Wang, Xing; Han, Ying; Sun, Guangwei; Li, Yao; Zhou, Jinghui

doi:10.1016/j.msec.2019.110002

Cited by 243 publications

(135 citation statements)

References 35 publications

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“…The hydrogen bonding between the -OH, =CO, and R-O-R groups of both lignin, as well as chitosan, exhibits the formation of intermolecular interaction. [119] The incorporation of lignin into chitosan-PVA composite hydrogel enhances the mechanical strength and the adsorption capacity of the protein. The lignin-chitosan-PVA composite hydrogel (LCPH) effectively improved wound healing in a rat wound model, indicating high potential in skin wound care.…”

Section: Ligninmentioning

confidence: 99%

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3D Bioprinting of Lignocellulosic Biomaterials

Shavandi

Hosseini

Okoro

et al. 2020

Adv Healthcare Materials

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The interest in bioprinting of sustainable biomaterials is rapidly growing, and lignocellulosic biomaterials have a unique role in this development. Lignocellulosic materials are biocompatible and possess tunable mechanical properties, and therefore promising for use in the field of 3D‐printed biomaterials. This review aims to spotlight the recent progress on the application of different lignocellulosic materials (cellulose, hemicellulose, and lignin) from various sources (wood, bacteria, and fungi) in different forms (including nanocrystals and nanofibers in 3D bioprinting). Their crystallinity, leading to water insolubility and the presence of suspended nanostructures, makes these polymers stand out among hydrogel‐forming biomaterials. These unique structures give rise to favorable properties such as high ink viscosity and strength and toughness of the final hydrogel, even when used at low concentrations. In this review, the application of lignocellulosic polymers with other components in inks is reported for 3D bioprinting and identified supercritical CO2 as a potential sterilization method for 3D‐printed cellulosic materials. This review also focuses on the areas of potential development by highlighting the opportunities and unmet challenges such as the need for standardization of the production, biocompatibility, and biodegradability of the cellulosic materials that underscore the direction of future research into the 3D biofabrication of cellulose‐based biomaterials.

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Section: Ligninmentioning

confidence: 99%

“…A) The crosslinking mechanism of lignin-chitosan-PVA hydrogels, B) the tensile mechanism of LCPHs, and C) images of wounds with the control group with no dressing, lignin-free dressing, and lignin-containing dressing on the 0th, 5th, 10th, and 15th day after administration. [119] Reproduced with permission. [119] Copyright 2019, Elsevier.…”

Section: Figure 16mentioning

confidence: 99%

3D Bioprinting of Lignocellulosic Biomaterials

Shavandi

Hosseini

Okoro

et al. 2020

Adv Healthcare Materials

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“…Polyvinyl alcohol (PVA) is a biodegradable and environmentally friendly polymer material with good water solubility and membrane forming properties. Recently, PVA hydrogels with a three‐dimensional network built by crosslinked chain networks (physical or chemical one) have received much attention on its excellent biocompatibility and feasibility in many biomedical applications, such as agricultural application, biomedical applications, food packaging, separation and purification, catalytic chemistry, electrochemistry, adsorption chemistry, and so on. These numerous applications can be based on the specific hydrogen bonding between inter and intramolecular hydrogen bonds in PVA chains, whose strength has an influence of structure and mechanical properties of PVA gel .…”

Section: Introductionmentioning

confidence: 99%

Swelling Resistance and Mechanical Performance of Physical Crosslink‐Based Poly(Vinyl Alcohol) Hydrogel Film with Various Molecular Weight

Zhang

Bao

et al. 2019

J Polym Sci B Polym Phys

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The present work aimed to develop polyvinyl alcohol (PVA) hydrogel films with physically crosslinking through controllable entanglement density of the polymer chains. The viscoelasticity of PVA aqueous solutions was investigated over a broad range in molecular weight. The chain length between the crosslinks in the hydrogel (falseMe¯) and entanglement density was determined by the plateau modulus (G'). The value of (falseMe¯) increased with the PVA molecular weight, which can be attributed to the enhanced entanglement associated with the hydrogen bonds between inter‐ and interchains. The melting and crystallization of the transparent PVA hydrogel films showed that the crystallinity was below 30%, which indicated that microcrystallites formed. Therefore, the entanglement effect and microcrystallization enhanced the stable crosslinked hydrogel network, which further improved by an increase in the molecular weight. Altogether, the PVA with the molecular weight higher than 88,000 g/mol can be envisioned as a promising material for preparing the hydrogel film possessing excellent performance. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019, 57, 1673–1683

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“…Chitosan and polyvinylalcohol formed hydrogels in the presence of the lignin obtained as a by-product of sulfite papermaking pulp (sulfonation degree of 11.6%). FTIR and SEM microphotographs analyses pointed out the role of lignin as macromolecular crosslinking agent by hydrogen bonding between lignin and PVA hydroxyl groups, and by the electrostatic interactions between the cationic amino group of chitosan and the sulfonic moiety of lignin [39].…”

Section: Lignin Hydrogels By Chemical Interactionmentioning

confidence: 99%

Lignin-Based Hydrogels: Synthesis and Applications

et al. 2020

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Polymers obtained from biomass are an interesting alternative to petro-based polymers due to their low cost of production, biocompatibility, and biodegradability. This is the case of lignin, which is the second most abundant biopolymer in plants. As a consequence, the exploitation of lignin for the production of new materials with improved properties is currently considered as one of the main challenging issues, especially for the paper industry. Regarding its chemical structure, lignin is a crosslinked polymer that contains many functional hydrophilic and active groups, such as hydroxyls, carbonyls and methoxyls, which provides a great potential to be employed in the synthesis of biodegradable hydrogels, materials that are recognized for their interesting applicability in biomedicine, soil and water treatment, and agriculture, among others. This work describes the main methods for the preparation of lignin-based hydrogels reported in the last years, based on the chemical and/or physical interaction with polymers widely used in hydrogels formulations. Furthermore, herein are also reviewed the current applications of lignin hydrogels as stimuli-responsive materials, flexible supercapacitors, and wearable electronics for biomedical and water remediation applications.

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Novel lignin–chitosan–PVA composite hydrogel for wound dressing

Cited by 243 publications

References 35 publications

3D Bioprinting of Lignocellulosic Biomaterials

3D Bioprinting of Lignocellulosic Biomaterials

Swelling Resistance and Mechanical Performance of Physical Crosslink‐Based Poly(Vinyl Alcohol) Hydrogel Film with Various Molecular Weight

Lignin-Based Hydrogels: Synthesis and Applications

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