Novel low-shrinkage-stress nanocomposite with remineralization and antibacterial abilities to protect marginal enamel under biofilm

Bhadila, Ghalia; Wang, Xiaohong; Zhou, Wen; Menon, Deepak; Melo, Mary Anne S.; Montaner, Silvia; Oates, Thomas W.; Weir, Michael D.; Sun, Jirun; Xu, Hockin H.K.

doi:10.1016/j.jdent.2020.103406

Cited by 31 publications

(42 citation statements)

References 56 publications

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“…In this study, the first strategy to prevent secondary caries is based on the release of ions related to remineralization. Ca and P ions are released from the PBG and enhance tooth remineralization and prevent mineral loss, as previously reported [33]. The remineralization mechanism of the bioactive-glass-containing resin composite is mainly attributed to the release of ions from the bioactive glass at the composite surface, resulting in the formation of a hydroxycarbonate apatite layer on the glass surface, and the interaction of the released ions with the demineralized tissue [13].…”

Section: Discussionsupporting

confidence: 55%

“…This effect stems from the influence of cationic ions in increasing the pH of the surroundings and also by the intracellular incursion of zinc ions, which causes disruption of the cell membrane [32]. In addition to the antibacterial activity of the zinc ions, the combined action of Ca, P, Na, and Si ions has been suggested to cause an anabolic response [33].…”

Section: Discussionmentioning

confidence: 99%

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Development of a Bioactive Flowable Resin Composite Containing a Zinc-Doped Phosphate-Based Glass

Lee

Seo

et al. 2020

Nanomaterials

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Flowable resins used for dental restoration are subject to biofilm formation. Zinc has antibacterial properties. Thus, we prepared a zinc-doped phosphate-based glass (Zn-PBG) to dope a flowable resin and evaluated the antibacterial activity of the composite against Streptococcus mutans (S. mutans) to extrapolate the preventative effect toward secondary caries. The composites were prepared having 0 (control), 1.9, 3.8, and 5.4 wt.% Zn-PBG. The flexural strength, elastic modulus, microhardness, depth of cure, ion release, inhibition zone size, and number of colony-forming units were evaluated and analyzed using ANOVA. The flexural strength of the control was significantly higher than those of Zn-PBG samples (p < 0.05). However, all samples meet the International Standard, ISO 4049. The microhardness was not significantly different for the control group and 1.9 and 3.8 wt.% groups, but the 5.4 wt.% Zn-PBG group had a significantly lower microhardness (p < 0.05). Further, the composite resins increasingly released P, Ca, Na, and Zn ions with an increase in Zn-PBG content (p < 0.05). The colony-forming unit count revealed a significant reduction in S. mutans viability (p < 0.05) with increase in Zn-PBG content. Therefore, the addition of Zn-PBG to flowable composite resins enhances antibacterial activity and could aid the prevention of secondary caries.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Development of a Bioactive Flowable Resin Composite Containing a Zinc-Doped Phosphate-Based Glass

Lee

Seo

et al. 2020

Nanomaterials

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“…While the novel denture acrylic resin with antimicrobial properties in the present study showed promising results, these new resins are required to be biocompatible and non-cytotoxic. The cytotoxicity of dental monomers has been evaluated by several investigators [19,[33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis

et al. 2022

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Denture stomatitis is a multifactorial pathological condition of the oral mucosa that affects up to 72% of denture wearers. It is commonly seen on the palatal mucosa and characterized by erythema on the oral mucosa that are in contact with the denture surface. The aim of this study was to incorporate 2-methacryloyloxyethyl phosphorylcholine (MPC) and dimethylaminohexadecyl methacrylate (DMAHDM) into a high impact polymethylmethacrylate heat-cured denture base acrylic resin as a potential treatment for denture stomatitis. We used a comparative study design to examine the effect of incorporating MPC as a protein repellent agent and DMAHDM as an antifungal agent to prevent the adherence of Candida albicans to the denture base material. The dual incorporation of MPC and DMAHDM reduced C. albicans biofilm colony-forming unit by two orders of magnitude when compared to the control group devoid of the bioactive agents. Although the addition of MPC and DMAHDM alone or in combination significantly reduced the flexural strength of the material, they showed reduced roughness values when compared to control groups. This new denture acrylic resin provides the benefit of enhancing C. albicans biofilm elimination through dual mechanisms of action, which could potentially reduce the prevalence of denture stomatitis.

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“…Moreover, these antibacterial monomer/drug/metal oxide NPs have no remineralizing ability, largely impeding their development as composite resins ( Cocco et al, 2015 ; Arun et al, 2021 ). Recently, promising alternatives such as bioactive ceramic particles [e.g., calcium phosphate nanoparticles (NACPs), bioactive glass (BAG), zinc-doped phosphate-based glass] have been exploited as inorganic fillers to construct orthodontic adhesives or composite resins, which have been found to achieve both antibacterial and remineralizing effects ( Liu et al, 2018 ; Par et al, 2019b ; Bhadila et al, 2020 ; Lee et al, 2020 ). Among bioactive ceramic particles, BAG has attracted increasing interest in dental applications such as toothpaste, dentin desensitizers, orthodontic adhesives, and experimental composite resins ( Wang et al, 2010 ; Yang et al, 2016 ; Al-Eesa et al, 2019 ; Aponso et al, 2019 ; Par et al, 2019a ).…”

Section: Introductionmentioning

confidence: 99%

Novel Bioactive Glass-Modified Hybrid Composite Resin: Mechanical Properties, Biocompatibility, and Antibacterial and Remineralizing Activity

Han

Chen

Jiao

et al. 2021

Front. Bioeng. Biotechnol.

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Secondary caries seriously limits the lifetime of composite resin. However, integrating all desirable properties (i.e., mechanical, antibacterial, bioactivity, and biocompatibility) into one composite resin is still challenging. Herein, a novel bioactive glass (BAG)-modified hybrid composite resin has been successfully developed to simultaneously achieve excellent mechanical properties, good biocompatibility, and antibacterial and remineralizing capabilities. When the mass fractions of BAG particles were added from 8 to 23 wt %, the original mechanical properties of the composite resin, including flexural strength and compressive strength, were not obviously affected without compromising the degree of conversion. Although the BAG incorporation of mass fractions of 16 wt % to 23 wt % in composite resins reduced cell viability, the viability could be recovered to normal by adjusting the pH value. Moreover, the BAG-modified composite resins that were obtained showed good antibacterial effects against Streptococcus mutans and enhanced remineralizing activity on demineralized dentin surfaces with increasing incorporation of BAG particles. The possible mechanisms for antibacterial and remineralizing activity might be closely related to the release of bioactive ions (Ca2+, Si4+), suggesting that its antibacterial and biological properties can be controlled by modulating the amounts of bioactive ions. The capability to balance the mechanical properties, cytotoxicity, antibacterial activity, and bioactivity makes the BAG-modified composite resin a promising prospect for clinical application. Our findings provide insight into better design and intelligent fabrication of bioactive composite resins.

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Novel low-shrinkage-stress nanocomposite with remineralization and antibacterial abilities to protect marginal enamel under biofilm

Cited by 31 publications

References 56 publications

Development of a Bioactive Flowable Resin Composite Containing a Zinc-Doped Phosphate-Based Glass

Development of a Bioactive Flowable Resin Composite Containing a Zinc-Doped Phosphate-Based Glass

Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis

Novel Bioactive Glass-Modified Hybrid Composite Resin: Mechanical Properties, Biocompatibility, and Antibacterial and Remineralizing Activity

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