Novel magnetic nanoparticle-containing adhesive with greater dentin bond strength and antibacterial and remineralizing capabilities

Li, Yuncong; Hu, Xiaoyi; Xia, Yang; Ji, Yadong; Ruan, Jianping; Weir, Michael D.; Lin, Xiaoying; Nie, Zhihong; Gu, Ning; Masri, Radi; Chang, Xiaofeng; Xu, Hockin H.K.

doi:10.1016/j.dental.2018.06.001

Cited by 43 publications

(26 citation statements)

References 70 publications

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“…Specimens subjected to above mentioned microorganisms exhibited different moderate antibacterial properties as demonstrated in Table 1. It can be concluded that the highest activity was attributed to the higher concentrations of iron oxide, which is in consistence with early reported research 19 …”

Section: Resultssupporting

confidence: 90%

“…This result could be owed to that the presence of iron in the ceramic matrix has increased the repulsive energy between the obtained particles, which in turn diminish their final diameters. Similar studies had revealed the effect of iron doping, addition and substitution and other transition metals on their native materials 17‐19 …”

Section: Resultsmentioning

confidence: 58%

“…Similar studies had revealed the effect of iron doping, addition and substitution and other transition metals on their native materials. [17][18][19] The mechanical strength of pre-molded, compacted ceramic nanopowders was investigated by universal testing machine and their stress-strain curves (Figure 4). Generally, it's obvious that stressstrain curves demonstrated typical mechanical performance of ceramic materials with acceptable strengths.…”

Section: Materials Characterizationsmentioning

confidence: 99%

“…It can be concluded that the highest activity was attributed to the higher concentrations of iron oxide, which is in consistence with early reported research. 19…”

Section: Antibacterial Activitymentioning

confidence: 99%

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Radiological evaluations of low cost wollastonite nano‐ceramics graft doped with iron oxide in the treatment of induced defects in canine mandible

et al. 2020

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Wollastonite with/without maghemite [(Fe2O3), 0, 3 and 10 wt%] was prepared by facile wet precipitation method. Effect of Fe2O3 presence in the obtained nano‐ceramics on physical structure, morphology, size and the mechanical features was evaluated using X‐ray diffraction, transmission electron microscope, and universal testing machine. Moreover, the in vitro biomineralization was examined using simulated body fluid (SBF) by means of scanning electron microscope/energy dispersive X‐ray, Fourier transform infrared, and inductively coupled plasma. An in vivo study was conducted on 24 adult male mongrel dogs to test the biosafety of fabricated samples in the reconstruction of experimentally induced mandibular bone defects. Bone density was measured through cone beam computed tomography analysis conducted at 1 and 3 months following surgery. Wollastonite was the main phase in all the prepared samples however little maghemite was developed in Fe‐containing samples. No remarkable changes were recognized for physical structure of obtained microcrystalline structures, however, a decrease in particle size was noted in the existence of Fe2O3 (10‐15 nm) when compared to the pure wollastonite (30–50 nm). Mechanical features were dependent on the included Fe2O3 concentration within the wollastonite ceramic matrix. The degree of biomineralization of the samples immersed in SBF was elevated with the increase in Fe2O3 percentage. Clinically, the reconstruction of bone defects was uneventful without any adverse toxic effect. Bone density was significantly increased at 1 and 3 months (p < .001) in grafted defects compared to control ones. Increasing the doping concentrations of iron oxide was associated with significant increase (p < .001) of bone density in all induced defects. Due to the impressive healing effect of current fabricated nano‐ceramics, they are recommended to be utilized as low cost bone graft alternatives.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 58%

Section: Materials Characterizationsmentioning

confidence: 99%

“…It can be concluded that the highest activity was attributed to the higher concentrations of iron oxide, which is in consistence with early reported research. 19…”

Section: Antibacterial Activitymentioning

confidence: 99%

See 2 more Smart Citations

Radiological evaluations of low cost wollastonite nano‐ceramics graft doped with iron oxide in the treatment of induced defects in canine mandible

et al. 2020

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“…The combination of DMAHDM, 2-methacryloyloxyethyl phosphorylcholine (MPC) and NACP was also researched [29,30,31,32,40,41,42]. MPC, one of the most common biocompatible and hydrophilic biomedical polymers, was incorporated into dentin bonding agents and composites due to its hydrophilicity that prevents the adsorption of proteins [32,33].…”

Section: Antimicrobial Applications In Dentistrymentioning

confidence: 99%

Application of Antimicrobial Nanoparticles in Dentistry

2019

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Oral cavity incessantly encounters a plethora of microorganisms. Plaque biofilm—a major cause of caries, periodontitis and other dental diseases—is a complex community of bacteria or fungi that causes infection by protecting pathogenic microorganisms from external drug agents and escaping the host defense mechanisms. Antimicrobial nanoparticles are promising because of several advantages such as ultra-small sizes, large surface-area-to-mass ratio and special physical and chemical properties. To better summarize explorations of antimicrobial nanoparticles and provide directions for future studies, we present the following critical review. The keywords “nanoparticle,” “anti-infective or antibacterial or antimicrobial” and “dentistry” were retrieved from Pubmed, Scopus, Embase and Web of Science databases in the last five years. A total of 172 articles met the requirements were included and discussed in this review. The results show that superior antibacterial properties of nanoparticle biomaterials bring broad prospects in the oral field. This review presents the development, applications and underneath mechanisms of antibacterial nanoparticles in dentistry including restorative dentistry, endodontics, implantology, orthodontics, dental prostheses and periodontal field.

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Amyloid‐Like Rapid Surface Modification for Antifouling and In‐Depth Remineralization of Dentine Tubules to Treat Dental Hypersensitivity

Deng

et al. 2019

Advanced Materials

115

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occluding resins, dentin adhesives, [3] mineral nanoparticles, or remineralization coatings, such as commercially available Green Or, Hybrid Coat, Gluma Desensitizer, and Duraphat, as well as polyphenol-based coatings, have been proposed for DH treatment. [4][5][6] Unfortunately, the majority of existing desensitizers fail to obtain satisfactory results for treating DH because they only seal orifices within 10 µm of DTs instead of a deep occlusion, and these sealers tend to peel off due to mechanical friction (such as tooth brushing). With the mineralizing adhesives as example, they typically seal the dentin surface instead of in-depth of DTs. Moreover, the leaching of unpolymerized monomers from adhesives has been implicated in hypersensitivity, cytotoxicity, genotoxicity, estrogenicity, and alteration of immune responses. [7] On the other hand, the antifouling property has been ignored for a long time in existing desensitizing products, and as a result, oral bacteria easily adhere onto the salivary acquired pellicle (SAP)-coated mineral layer to form a biofilm, [8] which produce toxins and even cause chronic diseases such as pulpitis. To overcome the drawbacks of current products, developing a rapid and convenient occlusion technique in deep DTs combining antifouling and easy remineralization is necessary but challenging to treat DH with long-term curing stability.Recently, our work demonstrated that lysozyme could undergo a fast amyloid-like aggregation in physiological conditions through the rapid reduction of its intramolecular disulfide bonds by tris(2-carboxyethyl)phosphine (TCEP). [9] In this process, the high-energy α-helix structure of native lysozyme is unfolded and aggregates into β-sheet stacking-based oligomers. A protein nanofilm, also called phase-transitioned lysozyme (PTL), is then formed in ≈2 h through the agglomeration of the oligomers at the liquid/solid interface, offering a robust, multifunctional, biocompatible and colorless transparent coating on flat or porous macroscopic substrates as well as micro/nanoparticles. [10,11] In the present study, we report a greatly deep occlusion of DTs by coating DTs with antifouling amyloid-like lysozyme oligomer aggregates and occluding with in situ formation of a biomimetic hydroxyapatite (HAp) layer on the coating. We demonstrate that the oligomer species, Exposure of dentinal tubules (DTs) leads to the transmission of external stimuli within the DTs, causing dental hypersensitivity (DH). To treat DH, various desensitizers have been developed for occluding DTs. However, most desensitizers commercially available or in development are only able to seal the orifices, rather than the deep regions of the DTs, thus lacking long-term stability. Herein, it is shown that the fast amyloid-like aggregation of lysozyme (lyso) conjugated with poly(ethylene glycol) (PEG) (lyso-PEG) can afford a robust ultrathin nanofilm on the deep walls of DTs through a rapid one-step aqueous coating process (in 2 min). The resultant nanofilm provides a highly effective antifoul...

show abstract

Novel magnetic nanoparticle-containing adhesive with greater dentin bond strength and antibacterial and remineralizing capabilities

Cited by 43 publications

References 70 publications

Radiological evaluations of low cost wollastonite nano‐ceramics graft doped with iron oxide in the treatment of induced defects in canine mandible

Radiological evaluations of low cost wollastonite nano‐ceramics graft doped with iron oxide in the treatment of induced defects in canine mandible

Application of Antimicrobial Nanoparticles in Dentistry

Amyloid‐Like Rapid Surface Modification for Antifouling and In‐Depth Remineralization of Dentine Tubules to Treat Dental Hypersensitivity

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