Novel modified nanoporous silica for oral drug delivery: loading and release of clarithromycin

Abadi, Iman Jabbari Zahir; Sadeghi, Omid; Zhad, Hamid Reza Lotfizadeh; Tavassoli, Najmeh; Amani, Vahid; Amini, Mostafa M.

doi:10.1007/s10971-011-2595-4

Cited by 20 publications

(2 citation statements)

References 18 publications

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“…HPLC is the most prominent technique for assay and determination of related substances of the three antibiotics selected in this study. Indeed, a number of HPLC methods have been reported for the assay of azithromycin , clarithromycin and clindamycin . HPLC has also been used as official assay or related substances method for these drugs in the European Pharmacopoeia .…”

Section: Introductionmentioning

confidence: 99%

Capillary electrophoresis with capacitively coupled contactless conductivity detection method development and validation for the determination of azithromycin, clarithromycin, and clindamycin

Paul

Duchateau

Griend

et al. 2017

J of Separation Science

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A capillary electrophoresis with capacitively coupled contactless conductivity detection based method for the assay of azithromycin, clarithromycin and clindamycin was optimized and validated in this study. A buffer solution of 20 mM 2-(N-morpholino) ethane sulfonic acid, 40 mM l-histidine and 0.6 mM cetyltrimethylammonium bromide (pH 6.39) was used for the electrophoresis. An uncoated, bare-fused silica capillary (total length 60 cm, effective length 32 cm, 75 μm id) was used at 25°C. The sample was injected hydrodynamically at 0.5 psi for 5 s. The electrophoresis was conducted at 30 kV in reverse polarity for 6 min with 3 and 2 min of in-between sodium hydroxide (0.1 M) and background electrolyte rinsing, respectively. Ammonium acetate was used as internal standard. This simple and robust method showed reasonable limit of detection and limit of quantitation for azithromycin (0.0125/0.03 mg/mL), clarithromycin (0.017/0.03 mg/mL), and clindamycin (0.038/0.06 mg/mL), with good selectivity, precision both intraday (relative standard deviation ≤ 1.0%) and interday (relative standard deviation < 3.7%), linearity (R > 0.999) and recovery (99 - 101.7%). The method was successfully applied for the determination of azithromycin, clarithromycin and clindamycin in formulations.

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Section: Introductionmentioning

confidence: 99%

Capillary electrophoresis with capacitively coupled contactless conductivity detection method development and validation for the determination of azithromycin, clarithromycin, and clindamycin

Paul

Duchateau

Griend

et al. 2017

J of Separation Science

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“…It was an efficient pH-responsive carrier system structured by hydrogen binding the amine group in nanoparticle and hydroxyl and carboxyl groups in the clarithromycin. Active molecule of clarithromycin, could be stored and released from the pore voids by changing the pH [25]. Silica based -chitosan nanoporous composites were also applied for innovative mucoadhesive oral insulin formulation.…”

Section: (Fig1)mentioning

confidence: 99%

A Review on Application of Novel Solid Nanostructures in Drug Delivery

Faraji

Nourmohammadi

Malaekeh-Nikouei

et al. 2018

JNanoR

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Nanotechnology as a multidisciplinary and scientific innovation plays an important role in numerous biomedical applications, such as molecular imaging, biomarkers and biosensors and also drug delivery. A wide range of studies have been conducted on using of nanoparticles for early diagnosis and targeted drug therapy of various diseases. In fact, the small size, customized surface, upgraded solubility, or multi-functionality of nanoparticles enabled them to interact with complex cellular functions in new ways which opened many doors and created new biomedical applications. These studies demonstrated that nanotechnology vehicles can formulate biological products effectively, and this nano-formulated products with a potent ability against different diseases, were represented to have better biocompatibility, bioaccessibility and efficacy, under in vitro and in vivo conditions.

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