Novel Nuclear Functions of Arabidopsis ARGONAUTE1: Beyond RNA Interference

Bajczyk, Mateusz; Bhat, Susheel Sagar; Szewc, Lukasz; Szweykowska-Kulińska, Zofia; Jarmołowski, Artur; Dolata, Jakub

doi:10.1104/pp.18.01351

Cited by 30 publications

(22 citation statements)

References 136 publications

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“…DCL1, together with a dsRNA binding protein HYPONASTIC LEAVES1 (HYL1) and a zinc-finger-containing protein SERRATE (SE), forms a core of the microprocessor complex that produces miRNA/miRNA* duplexes. Many other proteins interact with DCL1, HYL1, or SE for proper microRNA biogenesis [16,17,18,19]. Then, mature microRNA is loaded into AGO1 and exported to the cytoplasm as an AGO1/microRNA complex with the assistance of CHROMOSOMAL REGION MAINTENANCE1 (CMR1/EXPORTIN1) [20].…”

Section: Introductionmentioning

confidence: 99%

Micromanagement of Developmental and Stress-Induced Senescence: The Emerging Role of MicroRNAs

Świda-Barteczka

Szweykowska-Kulińska

2019

Genes

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MicroRNAs are short (19–24-nucleotide-long), non-coding RNA molecules. They downregulate gene expression by triggering the cleavage or translational inhibition of complementary mRNAs. Senescence is a stage of development following growth completion and is dependent on the expression of specific genes. MicroRNAs control the gene expression responsible for plant competence to answer senescence signals. Therefore, they coordinate the juvenile-to-adult phase transition of the whole plant, the growth and senescence phase of each leaf, age-related cellular structure changes during vessel formation, and remobilization of resources occurring during senescence. MicroRNAs are also engaged in the ripening and postharvest senescence of agronomically important fruits. Moreover, the hormonal regulation of senescence requires microRNA contribution. Environmental cues, such as darkness or drought, induce senescence-like processes in which microRNAs also play regulatory roles. In this review, we discuss recent findings concerning the role of microRNAs in the senescence of various plant species.

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Section: Introductionmentioning

confidence: 99%

Micromanagement of Developmental and Stress-Induced Senescence: The Emerging Role of MicroRNAs

Świda-Barteczka

Szweykowska-Kulińska

2019

Genes

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“…Interestingly, it was recently described that the mode of action of AGO1 is not only limited to the cytoplasm (Bajczyk et al, 2019). Indeed, nuclear AGO1 functions have been characterized (Figure 1) and involve miRNA loading (Bologna et al, 2018), chromatin control of miRNA or protein coding genes expressions (Dolota et al, 2016;Liu et al, 2018), DNA repair of photolesions (Schalk et al, 2017).…”

Section: Ago1 Homeostasis In Response To Abiotic Stressesmentioning

confidence: 99%

“…It was recently described that the mode of action of AGO1 is not only restricted to the post-transcriptional gene silencing pathway taking place in the cytoplasm. Indeed, several nuclear AGO1 functions have been identified (Bajczyk et al, 2019). Thus, the characterization of the different AGO1 pools implies that specific subcellular pathways might trigger AGO1 turnover and that complex regulatory processes might interplay to specifically fine tune AGO1 content.…”

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confidence: 99%

The Multilayer’s Control of ARGONAUTE 1 Contents

Molinier

2020

Molecular Plant

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“…Three phylogenetic clades of Arabidopsis AGO proteins—AGO1/AGO5/AGO10, AGO2/AGO3/AGO7, and AGO4/AGO6/AGO8/AGO9—play distinct roles in siRNA, miRNA, and/or RdDM pathways [177]. In particular, AGO1, AGO2, AGO4, AGO5, and AGO9 are associated with DNA repair and genome stability as well as the biogenesis and function of sncRNAs [177,178].…”

Section: Chromatin and Epigenetic Modifiers For Ddrmentioning

confidence: 99%

Chromatin Remodeling and Epigenetic Regulation in Plant DNA Damage Repair

Kim

2019

IJMS

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DNA damage response (DDR) in eukaryotic cells is initiated in the chromatin context. DNA damage and repair depend on or have influence on the chromatin dynamics associated with genome stability. Epigenetic modifiers, such as chromatin remodelers, histone modifiers, DNA (de-)methylation enzymes, and noncoding RNAs regulate DDR signaling and DNA repair by affecting chromatin dynamics. In recent years, significant progress has been made in the understanding of plant DDR and DNA repair. SUPPRESSOR OF GAMMA RESPONSE1, RETINOBLASTOMA RELATED1 (RBR1)/E2FA, and NAC103 have been proven to be key players in the mediation of DDR signaling in plants, while plant-specific chromatin remodelers, such as DECREASED DNA METHYLATION1, contribute to chromatin dynamics for DNA repair. There is accumulating evidence that plant epigenetic modifiers are involved in DDR and DNA repair. In this review, I examine how DDR and DNA repair machineries are concertedly regulated in Arabidopsis thaliana by a variety of epigenetic modifiers directing chromatin remodeling and epigenetic modification. This review will aid in updating our knowledge on DDR and DNA repair in plants.

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Novel Nuclear Functions of Arabidopsis ARGONAUTE1: Beyond RNA Interference

Cited by 30 publications

References 136 publications

Micromanagement of Developmental and Stress-Induced Senescence: The Emerging Role of MicroRNAs

Micromanagement of Developmental and Stress-Induced Senescence: The Emerging Role of MicroRNAs

The Multilayer’s Control of ARGONAUTE 1 Contents

Chromatin Remodeling and Epigenetic Regulation in Plant DNA Damage Repair

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