Novel ordered TiO2 nanodot array on 316LSS with enhanced antibacterial properties

Wei, Yuanyuan; Ma, Yuanhui; Chen, Jingjing; Yang, Xu-Zhao; Ni, Shirong; Hong, Feng; Ni, Siyu

doi:10.1016/j.matlet.2020.127503

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…In order to provide optimized tissue integration, the implant surfaces are tailored in such a way that the adsorption of proteins of the extracellular matrix is promoted and cell adhesion is favored [ 33 ]. This can be realized, for instance, by physicochemical nanostructuring processes and culminates in distinct geometries [ 37 , 38 , 39 , 40 ]. In particular, titania nanotube scaffolds (TNSs) have great potential due to their high aspect ratios and their enormous surface [ 41 ].…”

Section: Introductionmentioning

confidence: 99%

Laminin Adsorption and Adhesion of Neurons and Glial Cells on Carbon Implanted Titania Nanotube Scaffolds for Neural Implant Applications

et al. 2022

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Interfacing neurons persistently to conductive matter constitutes one of the key challenges when designing brain-machine interfaces such as neuroelectrodes or retinal implants. Novel materials approaches that prevent occurrence of loss of long-term adhesion, rejection reactions, and glial scarring are highly desirable. Ion doped titania nanotube scaffolds are a promising material to fulfill all these requirements while revealing sufficient electrical conductivity, and are scrutinized in the present study regarding their neuron–material interface. Adsorption of laminin, an essential extracellular matrix protein of the brain, is comprehensively analyzed. The implantation-dependent decline in laminin adsorption is revealed by employing surface characteristics such as nanotube diameter, ζ-potential, and surface free energy. Moreover, the viability of U87-MG glial cells and SH-SY5Y neurons after one and four days are investigated, as well as the material’s cytotoxicity. The higher conductivity related to carbon implantation does not affect the viability of neurons, although it impedes glial cell proliferation. This gives rise to novel titania nanotube based implant materials with long-term stability, and could reduce undesirable glial scarring.

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Section: Introductionmentioning

confidence: 99%

Laminin Adsorption and Adhesion of Neurons and Glial Cells on Carbon Implanted Titania Nanotube Scaffolds for Neural Implant Applications

et al. 2022

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“…Based on the excellent chemical stability and biosafety [ 1 ], titanium dioxide (TiO 2 ) is a popular medical ceramic with broad application for blood-contacting devices [ 2 , 3 ]. However, like most inorganic materials, TiO 2 has a shortage of insufficient anticoagulant properties [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Photo-functionalized TiO2 nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility

Jiang

Dai

Liu

et al. 2021

Bioactive Materials

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Titanium dioxide (TiO 2 ) has a long history of application in blood contact materials, but it often suffers from insufficient anticoagulant properties. Recently, we have revealed the photocatalytic effect of TiO 2 also induces anticoagulant properties. However, for long-term vascular implant devices such as vascular stents, besides anticoagulation, also anti-inflammatory, anti-hyperplastic properties, and the ability to support endothelial repair, are desired. To meet these requirements, here, we immobilized silver nanoparticles (AgNPs) on the surface of TiO 2 nanotubes (TiO 2 -NTs) to obtain a composite material with enhanced photo-induced anticoagulant property and improvement of the other requested properties. The photo-functionalized TiO 2 -NTs showed protein-fouling resistance, causing the anticoagulant property and the ability to suppress cell adhesion. The immobilized AgNPs increased the photocatalytic activity of TiO 2 -NTs to enhances its photo-induced anticoagulant property. The AgNP density was optimized to endow the TiO 2 -NTs with anti-inflammatory property, a strong inhibitory effect on smooth muscle cells (SMCs), and low toxicity to endothelial cells (ECs). The in vivo test indicated that the photofunctionalized composite material achieved outstanding biocompatibility in vasculature via the synergy of photo-functionalized TiO 2 -NTs and the multifunctional AgNPs, and therefore has enormous potential in the field of cardiovascular implant devices. Our research could be a useful reference for further designing of multifunctional TiO 2 materials with high vascular biocompatibility.

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Effects of native oxidation on Ti/TiO2 nanodot arrays and their plasmonic properties compared to Au nanodot arrays

Jung

Choi

2021

Applied Surface Science

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Novel ordered TiO2 nanodot array on 316LSS with enhanced antibacterial properties

Cited by 4 publications

References 14 publications

Laminin Adsorption and Adhesion of Neurons and Glial Cells on Carbon Implanted Titania Nanotube Scaffolds for Neural Implant Applications

Laminin Adsorption and Adhesion of Neurons and Glial Cells on Carbon Implanted Titania Nanotube Scaffolds for Neural Implant Applications

Photo-functionalized TiO2 nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility

Effects of native oxidation on Ti/TiO2 nanodot arrays and their plasmonic properties compared to Au nanodot arrays

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