Novel Potentiometric Non-Enzymatic Ascorbic Acid Sensor Based on Molybdenum Oxide Film and Copper Nanoparticles

Chou, Jung-Chuan; Lee, Kun-Tse; Lai, Chih-Hsien; Kuo, Po-Yu; Nien, Yu–Hsun; Huang, Yuhao; Kang, Zhi-Xuan

doi:10.1109/jsen.2021.3128941

Cited by 17 publications

(6 citation statements)

References 52 publications

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“…To verify the authenticity of the measurement results with and without the lactate/RuO 2 architecture, we used sensors without RuO 2 film and lactate modification as standard sensors and measured their average sensitivity, linearity, and repeatability. To analyze our sensor without sensing film and lactase, we followed the approach proposed in [ 43 ], in which we used the sensor without RuO 2 film and lactase modification as the standard sensor. This standard sensor was immersed in different concentrations of lactic acid solution.…”

Section: Resultsmentioning

confidence: 99%

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The Characteristics Analysis of a Microfluid-Based EGFET Biosensor with On-Chip Sensing Film for Lactic Acid Detection

Kuo

Chang

Lai

et al. 2022

Sensors

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In this research, a microfluid-based extended gate field-effect transistor (EGFET) biosensor with an on-chip sensing window (OCSW) was fabricated. The detection window was composed of six metal layers, and a ruthenium dioxide (RuO2) film was spattered on the surface and functionalized with lactase to detect lactic acid (LA). To detect LA in a more diversified way, a microfluidic system was integrated with the biosensor. Moreover, a special package was used to seal the sensing window and microfluidic tube and insulate it from other parts to prevent water molecule invasion and chip damage. The sensitivity analysis of the EGFET biosensor was studied by a semiconductor parameter analyzer (SPA). The static and dynamic measurements of the EGFET with sensing windows on a chip were analyzed. The sensing characteristics of the EGFET biosensor were verified by the experimental results. The proposed biosensor is suitable for wearable applications due to the advantages of its low weight, low voltage, and simple manufacturing process.

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Section: Resultsmentioning

confidence: 99%

“…The average sensitivity and linearity were 6.17 mV/mM and 0.899, respectively; the RSD was 57.04%, and the results were poor. Lactase, through the hydrogen ions, accumulates on the surface of the sensing film [ 43 ]. Different LA concentrations produce different response voltages.…”

Section: Resultsmentioning

confidence: 99%

The Characteristics Analysis of a Microfluid-Based EGFET Biosensor with On-Chip Sensing Film for Lactic Acid Detection

Kuo

Chang

Lai

et al. 2022

Sensors

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“…The interferents used were fructose (Fru), glucose (Glu), urea (UR), uric acid (UA), and ascorbic acid (AA), in addition to DA. The concentrations of various interfering substances were chosen within the normal range of human [39][40][41][42][43]. Figure 8 shows sensors with two different structures.…”

Section: F Interference Effects Of the Dopamine Sensormentioning

confidence: 99%

Tungsten Trioxide Nanoparticles Modified Cuprous Oxide Film Non-Enzymatic Dopamine Sensor

Chou,

Chen,

Yang

et al. 2024

IEEE J. Electron Devices Soc.

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Non-enzymatic dopamine (DA) sensors are important in diagnosing and treating human diseases. However, non-enzymatic sensors frequently encounter interference from other substances, posing a challenge of poor selectivity for such sensors. Herein, we prepared tungsten trioxide nanoparticles (WO3 NPs) via a simple hydrothermal method and immobilized them onto a cuprous oxide (Cu2O) film. The results demonstrate that WO3 NPs offer improved selectivity, thus avoiding interference from other substances. The DA sensor based on the Cu2O film modified with WO3 NPs exhibits excellent DA detection performance, with a wide linear range of 1 μM to 10 mM, a low limit of detection of 0.21 μM, and good selectivity against common interfering substances. This non-enzymatic DA sensor features a simple structure, easy fabrication, small size, and suitability for mass production.

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“…In this study, we prepared a urease/RuO 2 biosensor based on the methods described in Chou's research [28] and the structure formulations previously reported [27]. To fabricate the RuO 2 membrane, we have developed a biosensor based on a 30 mm × 40 mm PET substrate.…”

Section: B Fabrication Of the Arrayed Urease/ruo2 Sensing Windows And...mentioning

confidence: 99%

“…Ag demonstrates potential as a reference electrode due to its chemical stability [32]. Chou et al [28] developed a biosensor and replaced the conventional bulky Ag/AgCl reference electrode with a silver reference electrode. We conducted stability tests on the silver electrode using a V-T measurement system, measuring the voltage potential between the silver reference electrode and the ground.…”

Section: A the Stability Of The Silver Reference Electrodementioning

confidence: 99%

Design and Fabrication of PDMS Microfluidic Device Combined With Urea Biosensor for Dynamic and Static Measurements

Kuo

Wang

Hsu

et al. 2023

IEEE J. Electron Devices Soc.

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In this study, a more efficient, convenient, and cost-effective way was proposed to design and fabricate a polydimethylsiloxane (PDMS) microfluidic device using 3D printing and transfer techniques. Typically, sensor measurements can only be conducted by immersing the sensor in a solution under static conditions. However, in this study, a newly designed microfluidic device combined with a microfluidic system enables dynamic measurements with sensors. By controlling the flow and temperature of the test liquid, the physiological environment of the human body under various conditions can be simulated, resulting in more accurate and realistic data. During the dynamic condition, an average sensitivity of 6.396 mV/(mg/dL) and linearity of 0.999 were obtained at a flow rate of 75.0 μL/min. When the temperature was at 37 • C, the biosensor achieved an average sensitivity of 4.381 mV/(mg/dL) and a linearity of 0.999. The dynamic response time was 7 seconds, and the drift rate was 1.47 mV/hr. The experimental results obtained under dynamic conditions showed a significant improvement in the sensing characteristics of the urea biosensor compared with the results obtained under static conditions.

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Novel Potentiometric Non-Enzymatic Ascorbic Acid Sensor Based on Molybdenum Oxide Film and Copper Nanoparticles

Cited by 17 publications

References 52 publications

The Characteristics Analysis of a Microfluid-Based EGFET Biosensor with On-Chip Sensing Film for Lactic Acid Detection

The Characteristics Analysis of a Microfluid-Based EGFET Biosensor with On-Chip Sensing Film for Lactic Acid Detection

Tungsten Trioxide Nanoparticles Modified Cuprous Oxide Film Non-Enzymatic Dopamine Sensor

Design and Fabrication of PDMS Microfluidic Device Combined With Urea Biosensor for Dynamic and Static Measurements

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