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There are relatively few studies on uric acid biosensors that are modified with silver nanomaterials and have high selectivity for analytes and are potentiometric uric acid biosensor. But many studies had shown that using nanomaterials thus results in a greatly enhanced sensitivity, and it could keep the activity of an enzyme. We proposed to use the silver nanowires (AgNWs) to modify the NiO uric acid biosensor. Besides, we modified the calibration circuit for the drift effect and hysteresis effect, the results showed that using the calibration circuit had improved the drift rate and the hysteresis voltage of the NiO flexible arrayed uric acid biosensors, and at least improved the drift rate by about 70 %, the hysteresis voltage by about 20 %, respectively.INDEX TERMS Uric acid biosensor, nickel oxide (NiO), nanomaterials, drift effect, hysteresis effect, calibration circuit.

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