Novel reassortant H10N7 avian influenza viruses isolated from chickens in Eastern China

Wu, Haibo; Lu, Rufeng; Wu, Xiaoxin; Peng, Xiaorong; Xu, Lixin; Cheng, Linfang; Lu, Xiangyun; Jin, Changzhong; Xie, Tiansheng; Yao, Hang‐Ping; Wu, Nanping

doi:10.1016/j.jcv.2015.02.007

Cited by 11 publications

(9 citation statements)

References 17 publications

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“…Recently, an H10N7 virus was isolated from dead harbor seals in Denmark 12 . A novel reassortant H10N7 AIV was found in chickens in Eastern China 11 12 13 14 15 16 17 18 19 20 21 22 23 . Additionally, an H10N4 isolate caused an outbreak of respiratory disease in mink in Sweden 15 .…”

mentioning

confidence: 99%

Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks

Zhang

et al. 2016

Sci Rep

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Three H10 subtype avian influenza viruses were isolated from domestic ducks in China, designated as SH602/H10N8, FJ1761/H10N3 and SX3180/H10N7, with an intravenous pathogenicity index (IVPI) of 0.39, 1.60, and 1.27, respectively. These H10 viruses showed a complex pathology pattern in different species, although full genome characterizations of the viruses could not identify any molecular determinant underlying the observed phenotypes. Our findings describe the pathobiology of the three H10 subtype AIVs in chickens, ducks, and mice. FJ1761/H10N3 evolved E627K and Q591K substitutions in the gene encoding the PB2 protein in infected mice with severe lung damage, suggesting that H10 subtype avian influenza viruses are a potential threat to mammals.

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confidence: 99%

Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks

Zhang

et al. 2016

Sci Rep

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“…An H10N7 subtype influenza virus (A/Sydney/2/2010) caused infection of poultry abattoir workers in Sydney in 2010 ( 49 ). Despite the sporadic incursion of H10N7 human infections, there is limited information pertaining to the molecular characteristics of H10N7 viruses, especially in China ( 50 ). An in-depth phylogenetic analysis conducted on chicken isolates by Wu et al ( 50 ) indicated that the viruses contained genetic material from H10, H2, H7, and H3 AIV strains that were circulating at the same time.…”

Section: H10nx Viruses In Mammalian Species and Zoonotic Infectionmentioning

confidence: 99%

“…Moreover, H10N6 and H10N1 AIVs caused high mortality with systemic dissemination ( 47 ). Wu et al ( 50 ) conducted in vivo studies in mice with reassortant H10N7 viruses isolated from poultry in China. These viruses were found to be moderately pathogenic in mice.…”

Section: H10nx Viruses In Mammalian Species and Zoonotic Infectionmentioning

confidence: 99%

“…These viruses were found to be moderately pathogenic in mice. The viruses were also able to replicate in mice without prior adaptation ( 50 ). Mouse inoculation tests conducted by Wu et al ( 46 ) also showed that three H10Nx subtypes—H10N3, H10N7, and H10N8—isolated from chickens in eastern China have low pathogenicity in mice and can efficiently replicate in this species ( 46 ).…”

Section: H10nx Viruses In Mammalian Species and Zoonotic Infectionmentioning

confidence: 99%

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The Emergence and Zoonotic Transmission of H10Nx Avian Influenza Virus Infections

Everest

Billington

Daines

et al. 2021

mBio

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“…Although some H6 subtype strains showed high virulence in mice [ 93 94 ], avian-isolated H6 viruses are generally associated with mild-disease signs in mice [ 85 92 94 95 ]. Avian H10 subtype influenza viruses also led to only mild-to-moderate disease signs in mice [ 96 97 98 ]; one of the H10N8 human isolates, however, was highly virulent in mice [ 99 ]. Thus, the generation of lethal mouse-adapted H6 or H10 variants will be beneficial to evaluate the efficacy of the new vaccines and therapeutic agents.…”

Section: Adaptation Using Avian Influenza Viruses In Micementioning

confidence: 99%

The significance of avian influenza virus mouse-adaptation and its application in characterizing the efficacy of new vaccines and therapeutic agents

Choi

Lloren

Baek

et al. 2017

Clin Exp Vaccine Res

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Due to the increased frequency of interspecies transmission of avian influenza viruses, studies designed to identify the molecular determinants that could lead to an expansion of the host range have been increased. A variety of mouse-based mammalian-adaptation studies of avian influenza viruses have provided insight into the genetic alterations of various avian influenza subtypes that may contribute to the generation of a pandemic virus. To date, the studies have focused on avian influenza subtypes H5, H6, H7, H9, and H10 which have recently caused human infection. Although mice cannot fully reflect the course of human infection with avian influenza, these mouse studies can be a useful method for investigating potential mammalian adaptive markers against newly emerging avian influenza viruses. In addition, due to the lack of appropriate vaccines against the diverse emerging influenza viruses, the generation of mouse-adapted lethal variants could contribute to the development of effective vaccines or therapeutic agents. Within this review, we will summarize studies that have demonstrated adaptations of avian influenza viruses that result in an altered pathogenicity in mice which may suggest the potential application of mouse-lethal strains in the development of influenza vaccines and/or therapeutics in preclinical studies.

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Novel reassortant H10N7 avian influenza viruses isolated from chickens in Eastern China

Cited by 11 publications

References 17 publications

Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks

Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks

The Emergence and Zoonotic Transmission of H10Nx Avian Influenza Virus Infections

The significance of avian influenza virus mouse-adaptation and its application in characterizing the efficacy of new vaccines and therapeutic agents

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