Novel riboflavin/VE-TPGS modified universal dentine adhesive with superior dentine bond strength and self-crosslinking potential

Daood, Umer; Sauro, Salvatore; Pichika, Malikarjuna Rao; Omar, Hanan; Lin, Seow Liang; Fawzy, A.

doi:10.1016/j.dental.2019.11.003

Cited by 15 publications

(10 citation statements)

References 44 publications

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“…Collagen crosslinkers were used as a substitute dentin pretreatment to improve the durability of the dentinal bonding and to strengthen the dentinal collagen fibrils [ 111 ]. This conclusion seems to match the finding of this paper, since the influence of the crosslinkers appears to develop with time to favour collagen in terms of preserving an expanded position, whereby monomers and solvents can be received inside the adhesive formulation [ 14 ].…”

Section: Discussionsupporting

confidence: 86%

“…After this, 2037 articles were excluded because they did not meet the inclusion criteria, leaving a total of 110 articles to be evaluated by full-text reading. Of these articles, 60 were not considered in the qualitative analysis: 1 article was in a language other than English [ 20 ], 2 studies were clinical trials [ 21 , 22 ], 1 study evaluated the BS only to carious dentin [ 23 ], 3 articles used the crosslinker agent within the composition of the phosphoric acid [ 24 , 25 , 26 ], 13 studies evaluated experimental adhesives [ 12 , 14 , 16 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ], for 5 articles we could not retrieve the full text [ 37 , 38 , 39 , 40 , 41 ], 25 articles did not evaluate any BS test [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ], 8 articles did not use a crosslinker agent [ ...…”

Section: Resultsmentioning

confidence: 99%

“…The improvement of the mechanical stability and physicomechanical properties of the collagen can be achieved by protecting them with several biomodifications using different collagen crosslinking agents [ 9 ]. The pretreatment of the dentin surface with these agents before bonding procedures may help increase the bond strength (BS) values and improve the stiffness of the resin–dentin bond [ 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. The dentinal mineral phase might be depleted, causing denudation of the collagen scaffold, which can become simply confronted by the bacterially derived enzymes or endogenous proteases.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Hardan

Daood

Bourgi

et al. 2022

Cells

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This study aimed to identify the role of crosslinking agents in the resin–dentin bond strength (BS) when used as modifiers in adhesives or pretreatments to the dentin surface through a systematic review and meta-analysis. This paper was conducted according to the directions of the PRISMA 2020 statement. The research question of this review was: “Would the use of crosslinkers agents improve the BS of resin-based materials to dentin?” The literature search was conducted in the following databases: Embase, PubMed, Scielo, Scopus, and Web of Science. Manuscripts that reported the effect on the BS after the use of crosslinking agents were included. The meta-analyses were performed using Review Manager v5.4.1. The comparisons were performed by comparing the standardized mean difference between the BS values obtained using the crosslinker agent or the control group. The subgroup comparisons were performed based on the adhesive strategy used (total-etch or self-etch). The immediate and long-term data were analyzed separately. A total of 50 articles were included in the qualitative analysis, while 45 articles were considered for the quantitative analysis. The meta-analysis suggested that pretreatment with epigallocatechin-3-gallate (EGCG), carbodiimide, ethylenediaminetetraacetic acid (EDTA), glutaraldehyde, and riboflavin crosslinking agents improved the long-term BS of resin composites to dentin (p £ 0.02). On the other hand, the use of proanthocyanidins as a pretreatment improved both the immediate and long-term BS values (p ≤ 0.02). When incorporated within the adhesive formulation, only glutaraldehyde, riboflavin, and EGCG improved the long-term BS to dentin. It could be concluded that the application of different crosslinking agents such as carbodiimide, EDTA, glutaraldehyde, riboflavin, and EGCG improved the long-term BS of adhesive systems to dentin. This effect was observed when these crosslinkers were used as a separate step and when incorporated within the formulation of the adhesive system.

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Section: Discussionsupporting

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Hardan

Daood

Bourgi

et al. 2022

Cells

View full text Add to dashboard Cite

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“…Throughout the protein preparation process, water molecules with less than three hydrogen bonds were removed. Hydrogen bonds (equivalent to pH 7.0) and missing side chain atoms and loops in the protein structure were added, followed by energy minimization by means of OPLS 2005 force field [44,45]. The binding site of collagen was detected using "binding site detection" function in Schrodinger 2019-4 suite.…”

Section: Molecular Docking Simulationsmentioning

confidence: 99%

“…The 3D chemical structure of D-ribose was drawn using a software called Maestro 11.8; and 3D structures were prepared using Ligprep module; OPLS 2005 force field was employed to create the low-energy conformers. Low energy conformations of the compounds were docked into the binding site by using an extra precision (XP) mode [45].…”

Section: Molecular Docking Simulationsmentioning

confidence: 99%

Reinforced Universal Adhesive by Ribose Crosslinker: A Novel Strategy in Adhesive Dentistry

et al. 2021

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Enzymatic biodegradation of demineralized collagen fibrils could lead to the reduction of resin–dentin bond strength. Therefore, methods that provide protection to collagen fibrils appear to be a pragmatic solution to improve bond strength. Thus, the study’s aim was to investigate the effect of ribose (RB) on demineralized resin–dentin specimens in a modified universal adhesive. Dentin specimens were obtained, standardized and then bonded in vitro with a commercial multi-mode adhesive modified with 0, 0.5%, 1%, and 2% RB, restored with resin composite, and tested for micro-tensile bond strength (µTBS) after storage for 24 h in artificial saliva. Scanning electron microscopy (SEM) was performed to analyze resin–dentin interface. Contact angles were analyzed using a contact angle analyzer. Depth of penetration of adhesives and nanoleakage were assessed using micro-Raman spectroscopy and silver tracing. Molecular docking studies were carried out using Schrodinger small-molecule drug discovery suite 2019-4. Matrix metalloproteinases-2 (MMP-2) and cathepsin-K activities in RB-treated specimens were quantified using enzyme-linked immunosorbent assay (ELISA). The significance level was set at α = 0.05 for all statistical analyses. Incorporation of RB at 1% or 2% is of significant potential (p < 0.05) as it can be associated with improved wettability on dentin surfaces (0.5% had the lowest contact angle) as well as appreciable hybrid layer quality, and higher resin penetration. Improvement of the adhesive bond strength was shown when adding RB at 1% concentration to universal adhesive (p < 0.05). Modified adhesive increased the resistance of collagen degradation by inhibiting MMP-2 and cathepsin-K. A higher RB concentration was associated with improved results (p < 0.01). D-ribose showed favorable negative binding to collagen. In conclusion, universal adhesive using 1% or 2% RB helped in maintaining dentin collagen scaffold and proved to be successful in improving wettability, protease inhibition, and stability of demineralized dentin substrates. A more favorable substrate is created which, in turn, leads to a more stable dentin-adhesive bond. This could lead to more advantageous outcomes in a clinical scenario where a stable bond may result in longevity of the dental restoration.

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The comparative evaluation of the effects of quercetin, α‐tocopherol, and chlorhexidine dentin pretreatments on the durability of universal adhesives

Moradian

Saadat

Sohrabniya

et al. 2022

Clinical & Exp Dental Res

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Objective The aim of this study was to evaluate and compare the effects of chlorhexidine, quercetin, and α‐tocopherol on the shear bond strength of universal adhesives in the short (24h) and long term (6 months). Material and Methods Ninety‐six extracted sound molars were collected and divided randomly into four groups: control (no treatment), 2% chlorhexidine, 10% α‐tocopherol, and 1% quercetin. The solutions were prepared and applied to the teeth for 60 s, followed by application of All‐Bond universal adhesive and composite build‐up. Half of the specimens in each group (n = 12) were tested for shear bond strength (SBS) after 24 h of storage and the other half were kept in distilled water for 6 months and then tested for shear bond strength. The shear bond strength test was performed and the failure modes were determined using a stereomicroscope. The data were analyzed using two‐way analysis of variance and Tukey's post hoc tests with p ˂ .05 as the significance level. Results The results of the two‐way analysis of variance test showed that there was no significant difference in immediate SBS, and after 6 months, α‐tocopherol had the lowest SBS in comparison to the control and CHX subgroups (p < .05). The t‐test showed that the shear bond strength in the α‐tocopherol and quercetin groups was significantly decreased after 6 months. Conclusion It can be concluded that the solutions used in this study had no adverse effect on immediate SBS. After 6 months, the CHX could preserve SBS in comparison to other groups.

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Novel riboflavin/VE-TPGS modified universal dentine adhesive with superior dentine bond strength and self-crosslinking potential

Cited by 15 publications

References 44 publications

Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Reinforced Universal Adhesive by Ribose Crosslinker: A Novel Strategy in Adhesive Dentistry

The comparative evaluation of the effects of quercetin, α‐tocopherol, and chlorhexidine dentin pretreatments on the durability of universal adhesives

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