Novel Risk Biomarker for Infective Endocarditis Patients With Normal Left Ventricular Ejection Fraction　― Monocyte to High-Density Lipoprotein Cholesterol Ratio ―

Wei, Xuebiao; Chen, Feng; Huang, Jun; He, Pengcheng; Wei, Yanxing; Tan, Ning; Chen, Jiyan; Yu, Danqing; Liu, Yuanhui

doi:10.1253/circj.cj-17-0427

Cited by 30 publications

(36 citation statements)

References 27 publications

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“…A significant correlation of a high MHR value with high CRP levels (r = 0.396) in patients with infective endocarditis and normal left ventricular ejection fraction was found, reflecting the value of MHR in predicting systemic inflammation (Wei et al, 2017 (Marenzi, Cosentino, & Bartorelli, 2015). A significant positive correlation between MHR and CRP (r = 0.456) was also shown.…”

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confidence: 69%

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Ganjali

Gotto

Ruscica

et al. 2018

Journal Cellular Physiology

219

188

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Inflammation and lipid accumulation are two basic hallmarks of atherosclerosis as a chronic disease. Inflammation not only is a local response but can also be considered as a systemic process followed by an elevation of inflammatory mediators. Monocytes are a major source of proinflammatory species during atherogenesis. In atherosclerosis, modified low-density lipoproteins (LDLs) are removed by macrophages; these are recruited in the vessel wall, inducing the release of inflammatory cytokines in inflamed tissue. Hence, inflammatory cholesterol ester-loaded plaque is generated. High-density lipoprotein-cholesterol (HDL-C) exhibits antiatherosclerotic effects by neutralizing the proinflammatory and pro-oxidant effects of monocytes via inhibiting the migration of macrophages and LDL oxidation in addition to the efflux of cholesterol from these cells. Furthermore, HDL plays a role in suppressing the activation of monocytes and proliferation-differentiation of monocyte progenitor cells. Thus, accumulation of monocytes and reduction of HDL-C may participate in atherosclerosis and cardiovascular diseases (CVD). Given that the relationship between the high number of monocytes and low HDL-C levels has been reported in inflammatory disorders, this review focused on understanding whether the monocyte-to-HDL ratio could be a convenient marker to predict atherosclerosis development and progression, hallmarks of CV events, instead of the individual monocyte count or HDL-C level.

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mentioning

confidence: 69%

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Ganjali

Gotto

Ruscica

et al. 2018

Journal Cellular Physiology

219

188

View full text Add to dashboard Cite

show abstract

“…In contrast, HDL-C protects endothelial cells from oxidative stress and inflammation by regulating monocytes activation and monocyte progenitors proliferation, and preventing monocytes assembly into the arterial wall [12][13][14]. High monocyte counts and low HDL-C levels have been shown to be positively associated with inflammation [17][18][19]. Therefore, while monocytes play a pro-inflammatory role, HDL-C functions as a reverse factor in the inflammatory process.…”

Section: Introductionmentioning

confidence: 99%

Impact of monocyte to high-density lipoprotein ratio on prevalent hyperuricemia: findings from a rural Chinese population

Chen

Shi

et al. 2020

Lipids Health Dis

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Background: Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a novel inflammatory marker that has been used to predict various inflammation-related diseases. This study aims to explore the association between MHR and prevalent hyperuricemia in a rural Chinese population. Methods: 8163 eligible participants (mean age: 54.13 years, males: 45.71%) from northeast China were enrolled in this cross-sectional study between 2012 to 2013. MHR was determined as blood monocyte count ratio to highdensity lipoprotein cholesterol concentration. Results: The prevalence of hyperuricemia was 12.86%. After adjusting for potential confounding factors, per SD increase of MHR caused a 25.2% additional risk for hyperuricemia, and the top quartile of MHR had an 82.9% increased risk for hyperuricemia compared with the bottom quartile. Additionally, smooth curve fitting and subgroup analyses showed a linear and robust association between MHR and prevalent hyperuricemia respectively. Finally, after introducing MHR into the established model of risk factors, the AUC displayed a significant improvement (0.718 vs 0.724, p = 0.008). Furthermore, Category-free net reclassification improvement (0.160, 95% CI: 0.096-0.224, P < 0.001) and integrated discrimination improvement (0.003, 95% CI: 0.002-0.005, P < 0.001) also demonstrated significant improvements. Conclusions: The present study suggests that MHR was positively and independently correlated with prevalent hyperuricemia among rural Chinese adults. Our results also implicate an important value for MHR in optimizing the risk stratification of hyperuricemia.

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“…Our patients with non-functional adrenal adenoma may possibly present in the early stage of inflammation and atherosclerosis, which might be explained why MHR does not associate with non-functional adrenal adenoma. Evidence suggests that CRP value, as a biomarker of systemic inflammation, predicts cardiovascular events and mortality (9,10,37,38). Serum hs-CRP value was reported to be increased in both patients with functional and non-functional adrenal tumor (19,34).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, our study showed that hs-CRP levels were elevated both in patients with functional and non-functional adenoma, and hs-CRP was positively related to the MHR value in patients with adrenal tumor. A significant correlation of high MHR value with high CRP levels in patients with infective endocarditis (37), acute coronary syndrome (10), coronary artery disease (9,38), and hypertensive patients (39). MHR with its positively relation to CRP, as a biomarker of inflammation, therefore using MHR with CRP would be a predictor of clinical cardiometabolic outcomes (1).…”

Section: Discussionmentioning

confidence: 99%

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Monocyte Count to HDL-Cholesterol Ratio May Be a Novel Cardiometabolic Marker in Patients With Functional Adrenal Tumors

Beysel

Çalışkan

Kızılgül

et al. 2019

Kocatepe Tıp Dergisi

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Monosit sayısının HDL-Kolesterole oranı (MHO), kardiyovasküler hastalığı olan hastalarda yüksek bulunmuş ve kardiyovasküler risk faktörleri için belirteç olduğu gösterilmiş. Fonksiyonel adrenal tümör ve fonksiyonel olmayan adrenal adenomlu hastalarda bile kardiyovasküler hastalık riski artmaktadır. Bu çalışmada ilk olarak, MHO'nun adrenal tümörlü hastalarda yüksek olup olmadığı ve kardiyometabolik risk faktörleri ile ilişkisi araştırıldı. GEREÇ VE YÖNTEM: Çalışmaya fonksiyonel adrenal tümürü olan 24 hasta (10 Cushing sendromu, 12 feokromositoma ve 2 primer hiperaldosteronizm), fonksiyonel olmayan adrenal adenomlu hasta (n=33) ve kontrol olgusu (n=50) alındı. Antropometrik inceleme, hormon ve biyokimyasal sonuçlar, lipid paneli, açlık kan şekeri (AKŞ), kan basıncı (KB), tam kan sayımı, C-reaktif protein (hs-CRP) ve karotis intima-media kalınlığı (KIMK) karşılaştırıldı. BULGULAR: Ortalama yaş (51.14±2.03'e karşın 54.01±9.37 yıl), cinsiyet dağılımı (kadın 66.7 %'a karşın 73.8 %) ve vücut kitle indeksi (31.12±3.38'a karşın 30.46±2.96 kg/m2) adrenal tümör ve kontrol grubu arasında benzerdi (sırasıyla, p>0.05). MHO değeri fonksiyonel tümör grubunda, fonksiyonel olmayan adenom ve kontrol grubuna göre, yüksek bulundu (13.79±3.14, 10,19±2,84 vs 10.08±1.82, sırasıyla, p<0.05). MHO değeri fonksiyonel olmayan adenom ve kontrol grubu arasında benzer bulundu (p>0,05). MHO değeri sistolik KB (r=0.480; p<0.001), diyastolik KB (r=0.452; p<0.001), AKŞ (r=0.333; p=0.001), hs-CRP (r=0.538, p=0.001) ve idrar normetanefrin düzeyi (r=0.302; p=0.043) ile pozitif korele idi. Kardiyovasküler hastalığı olan fonksiyonel adrenal tümörlü hastalarda, kardiyovasküler hastalığı olmayan fonksiyonel adrenal tümörlü hastalara göre, MHR değeri yüksek bulundu (14.69±2.67'e karşın 11.84±2.57, p<0.05). SONUÇ: Monosit sayısının HDL-Kolesterole oranı fonksiyonel adrenal tümörlü hastalarda yüksek bulunurken; fonksiyonel olmayan adenomlu hastalarda yüksek değildi. Monosit sayısının HDL-Kolesterole oranı kardiyometabolik risk faktörleri olan AKŞ, KB ve hs-CRP ile korele idi. Monosit sayısının HDL-Kolesterole oranı, fonksiyonel adrenal tümörlü hastalarda kardiyovasküler risk faktörleri için prediktif belirteç olabilir.

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Novel Risk Biomarker for Infective Endocarditis Patients With Normal Left Ventricular Ejection Fraction　― Monocyte to High-Density Lipoprotein Cholesterol Ratio ―

Cited by 30 publications

References 27 publications

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Impact of monocyte to high-density lipoprotein ratio on prevalent hyperuricemia: findings from a rural Chinese population

Monocyte Count to HDL-Cholesterol Ratio May Be a Novel Cardiometabolic Marker in Patients With Functional Adrenal Tumors

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Novel Risk Biomarker for Infective Endocarditis Patients With Normal Left Ventricular Ejection Fraction ― Monocyte to High-Density Lipoprotein Cholesterol Ratio ―

Cited by 30 publications

References 27 publications

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Impact of monocyte to high-density lipoprotein ratio on prevalent hyperuricemia: findings from a rural Chinese population

Monocyte Count to HDL-Cholesterol Ratio May Be a Novel Cardiometabolic Marker in Patients With Functional Adrenal Tumors

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Novel Risk Biomarker for Infective Endocarditis Patients With Normal Left Ventricular Ejection Fraction　― Monocyte to High-Density Lipoprotein Cholesterol Ratio ―