Novel scaffolds based on hydroxyapatite/poly(vinyl alcohol) nanocomposite coated porous TiO 2 ceramics for bone tissue engineering

Stipniece, Liga; Narkevica, Inga; Sokolova, Marina; Ločs, Jānis; Ozoliņš, Jurijs

doi:10.1016/j.ceramint.2015.09.101

Cited by 42 publications

(20 citation statements)

References 30 publications

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“…The SEM images of CHI/NHA and XAN–CHI/NHA NC scaffolds and their respective energy-dispersive X-ray spectroscopy (EDAX) spectrum are shown in Figure . As observed from SEM images, all NC scaffolds display porous, open, and interconnected network architecture, with pore size ranging from 100 to 500 μm, − which is conducive to regenerative tissue in-growth and transportation of nutrients, oxygen and metabolic products to and from encapsulated cells. , However, compared to the CHI/NHA NC scaffold (Figure a), the XAN–CHI/NHA NC scaffolds (Figure b–d) show even pore distribution and well-defined pores with less-collapsed pore walls. This can be attributed to the formation of XAN–CHI PEC which may have enhanced the pore-forming ability of the polymers as well as stiffness and modulus of pore walls.…”

Section: Resultsmentioning

confidence: 97%

Hydroxyapatite Nanoparticles Fortified Xanthan Gum–Chitosan Based Polyelectrolyte Complex Scaffolds for Supporting the Osteo-Friendly Environment

Zia

Jolly

Mirza

et al. 2020

ACS Appl. Bio Mater.

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Nanoparticle-reinforced polymer-based scaffolding matrices as artificial bone-implant materials are potential suitors for bone regenerative medicine as they simulate the native bone. In the present work, a series of bioinspired, osteoconductive tricomposite scaffolds made up of nanohydroxyapatite (NHA) embedded xanthan gum−chitosan (XAN−CHI) polyelectrolyte complex (PEC) are explored for their bone-regeneration potential. The Fourier transform infrared spectroscopy studies confirmed complex formation between XAN and CHI and showed strong interactions between the NHA and PEC matrix. The X-ray diffraction studies indicated regulation of the nanocomposite (NC) scaffold crystallinity by the physical cues of the PEC matrix. Further results exhibited that the XAN−CHI/NHA5 scaffold, with a 50/50 (polymer/NHA) ratio, has optimized porous structure, appropriate compressive properties, and sufficient swelling ability with slower degradation rates, which are far better than those of CHI/NHA and other XAN−CHI/NHA NC scaffolds. The simulated body fluid studies showed XAN− CHI/NHA5 generated apatite-like surface structures of a Ca/P ratio ∼1.66. Also, the in vitro cell−material interaction studies with MG-63 cells revealed that relative to the CHI/NHA NC scaffold, the cellular viability, attachment, and proliferation were better on XAN−CHI/NHA scaffold surfaces, with XAN−CHI/ NHA5 specimens exhibiting an effective increment in cell spreading capacity compared to XAN−CHI/NHA4 and XAN−CHI/ NHA6 specimens. The presence of an osteo-friendly environment is also indicated by enhanced alkaline phosphatase expression and protein adsorption ability. The higher expression of extracellular matrix proteins, such as osteocalcin and osteopontin, finally validated the induction of differentiation of MG-63 cells by tricomposite scaffolds. In summary, this study demonstrates that the formation of PEC between XAN and CHI and incorporation of NHA in XAN−CHI PEC developed tricomposite scaffolds with robust potential for use in bone regeneration applications.

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Section: Resultsmentioning

confidence: 97%

Hydroxyapatite Nanoparticles Fortified Xanthan Gum–Chitosan Based Polyelectrolyte Complex Scaffolds for Supporting the Osteo-Friendly Environment

Zia

Jolly

Mirza

et al. 2020

ACS Appl. Bio Mater.

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“…Polyvinyl alcohol (PVA) and polylactic acid (PLA) fibers are two stand-out representative biodegradable fibers which are widely used in the preparation of biodegradable bone scaffolds [21,22,23]. In this study, we evaluate the performance of HA coating prepared by electrodeposition on PVA/PLA braid.…”

Section: Introductionmentioning

confidence: 99%

Properties and Mechanism of Hydroxyapatite Coating Prepared by Electrodeposition on a Braid for Biodegradable Bone Scaffolds

Ling

Lin

et al. 2019

Nanomaterials

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Hydroxyapatite (HA) coating is successfully prepared by electrodeposition on the surface of polyvinyl alcohol (PVA)/polylactic acid (PLA) braid which serves as a potential biodegradable bone scaffold. The surface morphology, element composition, crystallinity and chemical bonds of HA coatings at various deposition times (60, 75, 90, 105 and 120 min) are characterized by scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDAX), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR), respectively. Average Surface roughness (Ra) of HA coating is observed by confocal microscopy. The results reveal that the typical characteristic peaks of the FTIR spectrum confirm that HA coating is successfully prepared on the rugged surface of the PVA/PLA braid. The XRD results indicate that the crystallinity of HA can be improved by increasing deposition time. In the 90 min-deposition, hydroxyapatite has a dense and uniform coating morphology, Ca/P ratio of 1.7, roughness of 0.725 μm, which shows the best electrodeposition performance. The formation mechanism of granular and plate-like hydroxyapatite crystals is explained by the structural characteristics of a hydroxyapatite unit cell. This study provides a foundation for a bone scaffold braided by biodegradable fibers.

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“…Porous titania (TiO 2 ) scaffolds developed using PU foams were reported to be 94% porous with macropores ranging from 100 to 500 μm. Also coating HAP/PVA on the developed TiO 2 scaffolds has enhanced the bioactivity in comparison to uncoated TiO 2 scaffolds . The same group has also attempted to produce electrically active TiO 2– x scaffolds by sintering for about 1200 °C/5 h under high-vacuum conditions.…”

Section: Manufacturing Techniquesmentioning

confidence: 99%

Comprehensive Review on Design and Manufacturing of Bio-scaffolds for Bone Reconstruction

Ravoor

Thangavel

Elsen

2021

ACS Appl. Bio Mater.

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Bio-scaffolds are synthetic entities widely employed in bone and soft-tissue regeneration applications. These bio-scaffolds are applied to the defect site to provide support and favor cell attachment and growth, thereby enhancing the regeneration of the defective site. The progressive research in bio-scaffold fabrication has led to identification of biocompatible and mechanically stable materials. The difficulties in obtaining grafts and expenditure incurred in the transplantation procedures have also been overcome by the implantation of bio-scaffolds. Drugs, cells, growth factors, and biomolecules can be embedded with bio-scaffolds to provide localized treatments. The right choice of materials and fabrication approaches can help in developing bio-scaffolds with required properties. This review mostly focuses on the available materials and bio-scaffold techniques for bone and soft-tissue regeneration application. The first part of this review gives insight into the various classes of biomaterials involved in bio-scaffold fabrication followed by design and simulation techniques. The latter discusses the various additive, subtractive, hybrid, and other improved techniques involved in the development of bio-scaffolds for bone regeneration applications. Techniques involving multimaterial printing and multidimensional printing have also been briefly discussed.

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Novel scaffolds based on hydroxyapatite/poly(vinyl alcohol) nanocomposite coated porous TiO 2 ceramics for bone tissue engineering

Cited by 42 publications

References 30 publications

Hydroxyapatite Nanoparticles Fortified Xanthan Gum–Chitosan Based Polyelectrolyte Complex Scaffolds for Supporting the Osteo-Friendly Environment

Hydroxyapatite Nanoparticles Fortified Xanthan Gum–Chitosan Based Polyelectrolyte Complex Scaffolds for Supporting the Osteo-Friendly Environment

Properties and Mechanism of Hydroxyapatite Coating Prepared by Electrodeposition on a Braid for Biodegradable Bone Scaffolds

Comprehensive Review on Design and Manufacturing of Bio-scaffolds for Bone Reconstruction

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