Novel versatile 3D bio-scaffold made of natural biocompatible hagfish exudate for tissue growth and organoid modeling

Dastjerdi, Mahsa Borzouyan; Amini, Abbas; Nazari, Marziyeh; Cheng, Chun; Benson, Veronika; Gholami, Ahmad; Ghasemi, Younes

doi:10.1016/j.ijbiomac.2020.05.024

Cited by 12 publications

(10 citation statements)

References 45 publications

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“…These effects, which are naturally less than GO/silver nanocomposites, could be due to the added effect of natural compounds attached to the nanoparticle surface due to bioinorganic synthesis. Such an additive effect has already been shown in other nanocomposites [ 20 , 24 , 26 , 30 ].…”

Section: Resultssupporting

confidence: 61%

“…ese effects, which are naturally less than GO/silver nanocomposites, could be due to the added effect of natural compounds attached to the nanoparticle surface due to bioinorganic synthesis. Such an additive effect has already been shown in other nanocomposites [20,24,26,30]. A recent study by Zachanowicz et al found that the number of viable bacteria was significantly reduced after exposure to binary polyrhodanine manganese ferrite nanohybrids.…”

Section: Antimicrobial Studiesmentioning

confidence: 66%

“…Zachanowicz et al have claimed that pure polyrhodanine has toxic effects in some concentrations [32]. In contrast, it is proven that [20,41]. After 24 h, PR/GO/Fe 3 O 4 , by increasing the concentration from 1 to 500 µg/mL, the cell viability percent decreased from 112 to approximately 36 because of polyrhodanine.…”

Section: Cytotoxic Studymentioning

confidence: 99%

“…Consequently, it is claimed that GO in its hybrid structure can provide low toxic effects that this toxicity can be manipulated by combining GO with other materials [9]. In the last ten years, GO/inorganic nanocomposites have raised substantial interests in biomedical application, with mainly significant antibacterial and anticancer potential [18][19][20]. In this study, we used a media composed of kombucha supernatant to synthesize polyrhodanine/Fe 3 O 4 modified by graphene oxide to control the cytotoxic effect and increase their antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

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Bioinorganic Synthesis of Polyrhodanine Stabilized Fe3O4/Graphene Oxide in Microbial Supernatant Media for Anticancer and Antibacterial Applications

Mousavi

Hashemi

Gholami

et al. 2021

Bioinorganic Chemistry and Applications

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Polyrhodanines have been broadly utilized in diverse fields due to their attractive features. The effect of polyrhodanine- (PR-) based materials on human cells can be considered a controversial matter, while many contradictions exist. In this study, we focused on the synthesis of polyrhodanine/Fe3O4 modified by graphene oxide and the effect of kombucha (Ko) supernatant on results. The general structure of synthetic compounds was determined in detail through Fourier-transform infrared spectroscopy (FT-IR). Also, obtained compounds were morphologically, magnetically, and chemically characterized using scanning electron microscopy (SEM) and vibrating sample magnetometer (VSM), energy dispersive X-ray (EDX) analysis. The antibacterial effects of all synthesized nanomaterials were done according to CLSI against four infamous pathogens. Also, the cytotoxic effects of the synthesized compounds on the human liver cancer cell line (Hep-G2) were assessed by MTT assay. Our results showed that Go/Fe has the highest average inhibitory effect against Escherichia coli and Pseudomonas aeruginosa, and this compound possesses the least antimicrobial effect on Staphylococcus aureus. Considering the viability percent of cells in the PR/GO/Fe3O4 compound and comparing it with GO/Fe3O4, it can be understood that the toxic effects of polyrhodanine can diminish the metabolic activity of cells at higher concentrations (mostly more than 50 µg/mL), and PR/Fe3O4/Ko exhibited some promotive effects on cell growth, which enhanced the viability percent to more than 100%. Similarly, the cell viability percent of PR/GO/Fe3O4/KO compared to PR/GO/Fe3O4 is much higher, which can be attributed to the presence of kombucha in the compound. Consequently, based on the results, it can be concluded that this novel polyrhodanine-based nanocompound can act as drug carriers due to their low toxic effects and may open a new window on the antibacterial agents.

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Section: Resultssupporting

confidence: 61%

Section: Antimicrobial Studiesmentioning

confidence: 66%

Section: Cytotoxic Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bioinorganic Synthesis of Polyrhodanine Stabilized Fe3O4/Graphene Oxide in Microbial Supernatant Media for Anticancer and Antibacterial Applications

Mousavi

Hashemi

Gholami

et al. 2021

Bioinorganic Chemistry and Applications

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“…Wound healing, a network of complex biological processes involving many extracellular and intracellular macromolecules, plays a significant role in skin remodeling and reestablishing the skin barrier following damages [1,2]. Management of the wound healing process costs billions of dollars per year directly, together with the time spent on its management.…”

Section: Introductionmentioning

confidence: 99%

Development and In Vivo Characterization of Probiotic Lysate-Treated Chitosan Nanogel as a Novel Biocompatible Formulation for Wound Healing

Ashoori

Mohkam

Heidari

et al. 2020

BioMed Research International

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Wound healing is a physiological reaction to tissue injuries which plays a crucial role in replacing the destroyed tissues. Probiotics produce valuable compounds that possess antibacterial and anti-inflammatory activities, immunomodulatory effects, and angiogenesis traits leading to the promotion of wound healing. Chitosan nanostructures have versatile properties making them quickly produced into gels, scaffolds, nanoparticles, beads, and sponge structures that can be incorporated into wound healing processes. In the current study, three formulations from nanogel consisting of probiotic supernatant (Lactobacillus reuteri, Lactobacillus fermentum, and Bacillus subtilis sp. natto)-loaded chitosan nanogels were prepared from the culture of corresponding cultures. The chitosan nanogels were previously characterized by Zetasizer, FTIR, and TEM. The prepared formulations’ effectiveness and dressing activity were assessed by evaluating wound closure and histological trials in Sprague-Dawley rats. The results indicated that all probiotic lysate formulations have advantages over the wound healing process. However, Bacillus subtilis natto has a better wound healing quality, which is well known in pathology examination. The favorable effects of probiotic lysate nanogels, including the reasonable wound closing rate, good wound appearance, and satisfactory histological observation via in vivo examination, suggest it as a promising nominee for wound healing purposes.

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An Overview on the Recent Advances in the Treatment of Infected Wounds: Antibacterial Wound Dressings

Mirhaj

Labbaf

Tavakoli

et al. 2022

Macromolecular Bioscience

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A wound can be surgical cuts from an operation or due to accident and trauma. The infected wound, as a result of bacteria growth within the damaged skin, interrupts the natural wound healing process and significantly impacts the quality of life. Wound dressing is an important segment of the skincare industry with its economic burden estimated at $ 20.4 billion (in 2021) in the global market. The results of recent clinical trials suggest that the use of modern dressings can be the easiest, most accessible, and most cost‐effective way to treat chronic wounds and, hence, holds significant promise. With the sheer number of dressings in the market, the selection of correct dressing is confusing for clinicians and healthcare workers. The aim of this research is to review widely used types of antibacterial wound dressings, as well as emerging products, for their efficiency and mode of action. In this review, introducing antibiotics and antibacterial nanoparticles as two important and clinically widely used categories of antibacterial agents is focused. The perspectives and challenges for paving the way for future research in this field are also discussed.

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Novel versatile 3D bio-scaffold made of natural biocompatible hagfish exudate for tissue growth and organoid modeling

Cited by 12 publications

References 45 publications

Bioinorganic Synthesis of Polyrhodanine Stabilized Fe3O4/Graphene Oxide in Microbial Supernatant Media for Anticancer and Antibacterial Applications

Bioinorganic Synthesis of Polyrhodanine Stabilized Fe3O4/Graphene Oxide in Microbial Supernatant Media for Anticancer and Antibacterial Applications

Development and In Vivo Characterization of Probiotic Lysate-Treated Chitosan Nanogel as a Novel Biocompatible Formulation for Wound Healing

An Overview on the Recent Advances in the Treatment of Infected Wounds: Antibacterial Wound Dressings

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