Novel water soluble dendrimer nanocarrier for enhanced photodynamic efficacy of protoporphyrin IX

Abstract

The present study describes the development and evaluation of a novel biocompatible dendrimer-based nano drug delivery system which is readily

Influence of Anionic Surface Charged Biocompatible Dendrimer With a Photosensitizer, Protoporphyrin IX, on Human Red Blood Cells: A Spectroscopic Investigation

“…It must be noted that the incorporation of PpIX inside the dendritic cavity of G2.5 has already been confirmed by Murugesan et al using UvVis. and FTIR spectroscopy [19]. It is further confirmed by Transmission Electron Microscope (TEM) in the present work.…”

“…Transform Infra-Red spectroscopy (FTIR, Bruker optics GmbH-Alpha T spectrometer, Germany) and Zeta potential (Malvern instrument, UK) was used for surface charge measurement [19]. It is stated that if the particles are having negative potentials above20mV, then the particles are said to be monodispersity.…”

“…The anionic surface charged PGSA dendrimer was synthesized using phloroglucinol (2,4,6 trihydroxy benzene) as a core and succinic acid as the branching units in the mole ratio of 1:3 initially to form the first half generation (G0.5) by reflux method [19]. Transform Infra-Red spectroscopy (FTIR, Bruker optics GmbH-Alpha T spectrometer, Germany) and Zeta potential (Malvern instrument, UK) was used for surface charge measurement [19].…”

Investigation of Phloroglucinol Succinic Acid Dendrimer as Antimicrobial Agent against Staphylococcus Aureus, Escherichia Coli and Candida Albicans

“…We developed a water soluble dendrimer of generations up to 2.5 with negative charges. The method used to synthesis dendrimer with anionic surface charge and techniques used to characterize the end product of every half and full generations such as Fourier Transform-Infrared spectroscopy (FT-IR), to confirm the presence of functional groups and Zeta potential for surface charges measurement in the terminals was already discussed by Murugesan et al [17]. This helps to understand the biocompatibility of the nano carrier which made to extend the present study to look for antimicrobial property in addition to its behaviour as a nano drug delivery system.…”

“…In the previous work, PGSA biocompatible dendrimer [17] with anionic surface charged (carboxylic acid and phenolic hydroxyl) groups has been synthesized and characterized, even the photodynamic efficacy of the photosensitizer, Protoporphyrin IX incorporated inside it was evaluated in DLA cell lines (in vitro). In an ongoing effort to expand the biomedical applications of this PGSA dendrimer broth dilution method, spectroscopic and molecular modelling studies have been used to clearly highlight the finding of anti-microbial property in addition to its service as drug delivery system for therapeutic molecules.…”