NQO1, MPO, CYP2E1, GSTT1 and GSTM1 polymorphisms and biological effects of benzene exposure—A literature review

Are polymorphisms in metabolism protective or a risk for reduced white blood cell counts in a Chinese population with low occupational benzene exposures?

“…14,15 A review reported that GSTM1 and GSTT1 showed some consistent associations with both biomarkers of exposure and effect. 13 In line with expectations, we found an elevated WBC in benzene-exposed workers with GSTT1 and GSTM1, respectively. Microsomal epoxide hydrolase encodes an enzyme that initiates an alternate benzene oxide metabolic pathway, forming catechol.…”

“…37 It has been reported that the overall effects of RsaI and PstI restriction polymorphism sites in the promoter region of the gene and in the DraI restriction site remain unclear. 13,38 In this study, we found a weak, but statistically significant association, between the CYP2E1 21293G.C (rs3813867), 21019 C.T (rs2031920), and WBC counts. Individuals with variant alleles of rs3813867 and rs2031920 had lower WBC counts, although linear regression showed no apparent association between CYP2E1 polymorphisms and WBC.…”

“…[13][14][15] Previous studies have explored the relationship between genetic polymorphisms and benzene metabolism on the premise of high exposure, or without precise measurements of air exposure, or with small numbers of participants. 13 The overall effects of polymorphism sites in some of the genes are unclear, especially the study of the promoter region of CYP2E1, which has yielded mixed results. 13 This paper explores the relationship of genes with benzene exposure and blood cell counts.…”

“…13 The overall effects of polymorphism sites in some of the genes are unclear, especially the study of the promoter region of CYP2E1, which has yielded mixed results. 13 This paper explores the relationship of genes with benzene exposure and blood cell counts. We adopted WBC counts as the biomarker and used the PCR-restriction fragment length polymorphism (RFLP) technique to determine gene polymorphisms to evaluate the susceptibility of individuals with different metabolic enzyme genetic polymorphisms to benzene-induced hematotoxicity.…”

Utilização de biomarcadores de genotoxicidade e expressão gênica na avaliação de trabalhadores de postos de combustíveis expostos a vapores de gasolina

“…Os polimorfismos em genes que codificam enzimas metabólicas têm sido cada vez mais utilizados a fim de tornar os estudos de exposição a substâncias tóxicas mais abrangentes com capacidade de identificar subgrupos susceptíveis à exposição 83 . A partir do metabolismo de solventes, especialmente do benzeno, podemos destacar alguns polimorfismos como indicadores de susceptibilidade genética à exposição.…”