“…However, when this homeostasis cannot be maintained and oxidative stress (i.e., the pathologic condition caused by the imbalance between ROS production and antioxidant response) occurs, the cell reacts by upregulating the synthesis of specific antioxidants and enzymes, through the modulation of different transcriptional factors, whose master regulator is represented by NF-E2 p45-related factor 2 (NRF2) [5,6]. Beside its role in redox maintenance of homeostasis, NRF2 functions span multiple cellular processes, including survival, metabolic and protein homeostasis, inflammation, and regulation of cell proliferation/differentiation [7][8][9][10][11]. Thus, it is not surprising that the deregulation of NRF2 expression or activity has been found in many diseases in which oxidative stress represents a typical pathologic feature, including cancer [12], multiple sclerosis (MS) [9], Alzheimer's disease (AD) [13], Parkinson's disease (PD) [13], and amyotrophic lateral sclerosis (ASL) [14].…”