Nuclear magnetic resonance in hypertrophic cardiomyopathy.

Abstract

SUMMARY The large differences in the spin lattice relaxation times (T1) of blood and myocardium (measured by nuclear magnetic resonance) allow the heart to be visualised without the use of contrast media. The findings using nuclear magnetic resonance in 11 unselected patients with hypertrophic cardiomyopathy were compared with those in equal numbers of normal subjects and patients with electrocardiographic features of left ventricular hypertrophy. In patients with hypertrophic cardiomyopathy characteristic septal hypertrophy was noted together with variable and sometimes pronounced hypertrophy of the left ventricular free wall, which is consistent with the heterogeneous nature of this disease. The mean (SD) ratio of septal to free wall thickness was 1*5(0-8) for patients with hypertrophic cardiomyopathy, 0.8(0.2) for those with left ventricular hypertrophy, and 0*9(0*2) for normal subjects. Although septal measurements by nuclear magnetic resonance were greater than those obtained by echocardiography there was a significant correlation between the two. Septal and free wall area were significantly smaller in normal subjects. There were no differences in septal or free wall T, values between the three groups.Non-gated nuclear magnetic resonance can detect septal and free wall hypertrophy. With the addition of multiple slice acquisition, rapid estimation of myocardial mass will be possible allowing the potentially important assessment of progression or regression of myocardial hypertrophy.

Diagnostic accuracy of a 2D left ventricle hypertrophy score for familial hypertrophic cardiomyopathy

“…We report here for the first time the diagnostic value of an echocardiographic 2D LVH score for familial HCM. The extent and quantification of hypertrophy in HCM are well determined by Scan Imatron 15 or MRI, 16,17 but these are not routinely available for diagnosis. Thus, along with ECG, echocardiography remains the most useful tool for screening of a population.…”

Cardiomyopathies (hypertrophy and failure): What can offer cardiac magnetic resonance imaging?

“…An advantage of MRI over other cardiac imaging modalities is the use of angled planes, which allows accurate measurement of the myocardial wall thickness [26]. In the asymmetric septal form of HCM, the mean ratio of septalto-free wall thickness is higher than 1.5 AE 0.8, compared with 0.9 AE 0.3 in normal volunteers and 0.8 AE 0.2 in patients with LV hypertrophy [20]. Using cine MRI sequences, obstructive can be differentiated from non-obstructive forms of septal HCM [24,27].…”

“…The arsenal of MRI sequences usable in HCM includes: SE MRI; cine MRI; velocity-encoded MRI; MRI tagging; CE-IR MRI; and MR spectroscopy. The presence, distribution, and severity of the hypertrophic process can precisely be evaluated with SE MRI and cine MRI [20][21][22][23][24][25]. An advantage of MRI over other cardiac imaging modalities is the use of angled planes, which allows accurate measurement of the myocardial wall thickness [26].…”

Diversity of the Localization of Myocardial Hypertrophy at the Apical Level in Patients with Apical Hypertrophy Evaluated by Magnetic Resonance Imaging

“…The usefulness of magnetic resonance imaging (MRI) for anatomical evaluations of the left ventricle [6,7], the The slice thickness was 10 mm, reconstruction matrix was 256 X 256 with spatial resolution of 1.6-2.0 mm and each cross-sectional image was obtained during 512 cardiac cycles. The left ventricular long-axis images were obtained in the right anterior oblique position with optimal degrees for the position ( fig.…”